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兔心室肌细胞电生理异质性研究--缺血对动作电位和钾流的影响

祁小燕, 施渭彬, 汪海宏, 张志雄, 徐有秋

上海中医药大学生理教研室.上海 200032；上海第二医科大学生理教研室.上海 200025

摘要

实验用全细胞膜片箝技术,观察正常及缺血条件下,兔心内膜下心室肌细胞与心外膜下心室肌细胞的动作电位和稳态外向钾流及其变化。结果提示:增加的稳态外向钾流大部分是由于缺血造成细胞内ATP缺乏,致使I_(K-ATP)通道开放,钾外流。

A study on the electrophysiological heterogeneity of rabbit ventricular myocytes--The effects of ischemia on action potentials and potassium currents

Qi Xiaoyan, Shi Weibin, Wang Haihong, Zhang Zhixiong, Xu Youqiu

Department of Physiology,Shanghai University of Traditional Chinese Medicine.Shanghai 200032；China

Abstract

With the whole-cell variant patch-clamp technique, action potentials (AP) and outward potassium currents of rabbit ventricular myocytes isolated from subendocardium and subepicardium were recorded and their changes were observed under normal and ischemia conditions. It is suggested that the increase of steady-state outward potassium currents during ischemia is mainly due to the opening of I_(K-ATP) channels as a result of the deficiency of intracellular ATP caused by ischemia.

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引用本文：

祁小燕, 施渭彬, 汪海宏, 张志雄, 徐有秋. 兔心室肌细胞电生理异质性研究--缺血对动作电位和钾流的影响[J]. 生理学报 2000; 52 (5): 360-364.

Qi Xiaoyan, Shi Weibin, Wang Haihong, Zhang Zhixiong, Xu Youqiu. A study on the electrophysiological heterogeneity of rabbit ventricular myocytes--The effects of ischemia on action potentials and potassium currents. Acta Physiol Sin 2000; 52 (5): 360-364 (in Chinese with English abstract).