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β-烟酰胺单核苷酸(NMN)抗衰老研究进展

韩苗, 华进联^*

西北农林科技大学动物医学院，陕西省干细胞工程技术研究中心，杨凌 712100

摘要

β-烟酰胺单核苷酸(β-nicotinamide mononucleotide, NMN)是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD)的前体物质，在提高NAD水平中发挥重要作用。NMN的摄入能够改变肠道微生物的组成与活力，恢复线粒体功能，抑制炎症通路的激活，发挥改善机体代谢、抗氧化应激及减轻炎症的作用，从而在衰老相关疾病(如心脏功能减退、生育能力降低、记忆障碍、糖尿病)防控中发挥显著的恢复效果，显示出有效且安全的抗衰老作用。中国对NMN的使用已经逐步放开，探究NMN发挥抗衰老作用的机制，提高NMN的生物合成是其广泛应用的重要方向。同时，NMN协同干细胞有望治疗与衰老相关的退行性疾病，促进人类和动物的整体健康。

关键词： β-烟酰胺单核苷酸(NMN); 衰老; 干细胞

Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN)

HAN Miao, HUA Jin-Lian^*

College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling 712100, China

Abstract

β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD), plays an important role in enhancing NAD levels. Intake of NMN can alter the composition and vitality of gut microbiota, restore mitochondrial function, inhibit inflammatory pathways, improve metabolism, counteract oxidative stress, and alleviate inflammation. NMN significantly improves recovery from aging-related diseases, such as diminished heart function, reduced fertility, memory decline, and diabetes. NMN demonstrates both efficacy and safety in anti-aging. The use of NMN in China has gradually gained acceptance, highlighting the importance of exploring the mechanism of NMN in anti-aging effects and improving the biosynthesis of NMN. In addition, NMN in combination with stem cells hold promise in the treatment of aging-related degenerative diseases and promote overall human and animal health.

Key words: β-nicotinamide mononucleotide (NMN); aging; stem cell

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通讯作者：华进联　　E-mail:

引用本文：

韩苗, 华进联. β-烟酰胺单核苷酸(NMN)抗衰老研究进展[J]. 生理学报 2024; 76 (6): 1032-1042.

HAN Miao, HUA Jin-Lian. Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN). Acta Physiol Sin 2024; 76 (6): 1032-1042 (in Chinese with English abstract).