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胚胎着床的过程与机制研究进展

许祺欣, 苏仁伟^*

华南农业大学兽医学院，广州 510642

摘要

哺乳动物的胚胎着床是胚胎与子宫内膜建立紧密联系的过程，是妊娠的起始和关键步骤，胚胎着床的失败直接导致 妊娠失败和不孕。近年来，随着技术的进步，胚胎着床的研究工作取得了长足的进展。本文旨在对近10年取得的和胚胎着 床有关的研究成果进行综述，重点关注包括腔上皮和腺上皮的子宫内膜上皮在着床过程中的变化、作用及分子机制，以及 上皮细胞与胚胎滋养层细胞和子宫基质细胞之间的相互作用。

关键词： 胚胎着床; 子宫内膜; 上皮极性; 子宫腺体

分类号：R332;R363.2;R329.2

Research progress in process and mechanisms of embryo implantation

XU Qi-Xin, SU Ren-Wei^*

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

Abstract

The onset of tight connection between embryo and uterine endometrium terms “embryo implantation”, the beginning and a key step of mammalian pregnancy. Defective implantation leads to failure of pregnancy and infertility. In recent years, along with the technological advance, researches on embryo implantation have achieved great advances. This paper reviews the key research achievements that have been reached in the last decade in the field of embryo implantation, focusing on the changes, roles, and underlying mechanisms of both luminal and glandular epithelia during implantation process, as well as their interactions with embryo trophoblast cells and endometrial stromal cells.

Key words: embryo implantation; uterine endometrium; luminal cell polarity; uterine glands

收稿日期：2019-07-13　　录用日期：2019-09-22

通讯作者：苏仁伟　　E-mail: renweisu@scau.edu.cn

DOI: 10.13294/j.aps.2020.0004

引用本文：

许祺欣, 苏仁伟. 胚胎着床的过程与机制研究进展[J]. 生理学报 2020; 72 (1): 91-104.

XU Qi-Xin, SU Ren-Wei. Research progress in process and mechanisms of embryo implantation. Acta Physiol Sin 2020; 72 (1): 91-104 (in Chinese with English abstract).