生理学报

常永生

2002年毕业于中国协和医科大学生化专业，获得博士学位。2002年在美国National Jewish Medical and Research Center做博士后。2006年5月回到医科院基础所生化系工作，2017年11月到天津医科大学工作。

主要研究方向
机体糖脂代谢

奖励和荣誉
国家杰出青年科学基金
科技部“创新人才推进计划”中青年科技创新领军人才
中组部“国家高层次人才特殊支持计划”科技创新领军人才

发表论文

Anfang Cui, Heng Fan, Yinliang Zhang, Yujie Zhang, Dong Niu, Shuainan Liu, Quan Liu, Wei Ma, Zhufang Shen, Lian Shen, Yanling Liu, Huabing Zhang, Yuan Xue, Ying Cui, Qinghua Wang, Xinhua Xiao, Fude Fang, Jichun Yang, Qinghua Cui, Yongsheng Chang*. Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. J Clin Invest, 2019 Apr 29;129(6):2266-2278
Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang*. Cold-inducible SIRT6 regulates thermogenesis of brown and beige fat. Cell Reports, 2017;20(3):641-654
Yang X, Chen Q, Sun L, Zhang H, Yao L, Cui X, Gao Y, Fang F, Chang Y. KLF10 transcription factor regulates hepatic glucose metabolism in mice. Diabetologia, 2017;60(12):2443-2452
Ying Cui, Aijun Qiao, Tao Jiao, Huabing Zhang, Yuan Xue, Yongkang Zou, Anfang Cui, Fude Fang, Yongsheng Chang*. Hepatic Forkhead Box Q1 (FOXQ1) Transcription Factor Regulates Glucose metabolism. Diabetologia, 2016;59(10):2229-2239
Huabing Zhang, Qi Chen, Min Yang, Bin Zhu, Ying Cui, Yuan Xue, Nin Gong, Anfang Cui, Min Wan, Lian Shen, Shutian Zhang, Fude Fang, Yongsheng Chang*. Mouse KLF11 regulates hepatic lipid metabolism. Journal of Hepatology, 2013;58(4):763-770
Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Yin Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang*. Mouse PNPLA3 influences systemic lipid and glucose homeostasis. Hepatology, 2011;54(2):509-521

陈丽红

大连医科大学医学科学研究院三级教授
Email：bjclh2000@163.com
电话：18519254416
地址：辽宁省大连市旅顺口区旅顺南路西段9号，大连医科大学医学科学研究院

学习和工作经历
2016-至今大连医科大学，特聘研究员，教授，博士生导师
2016-至今深圳市罗湖医院集团众循精准医学研究院，特聘教授（兼职）
2017-至今大连市核受体与重大代谢疾病研究重点实验室，副主任
2014-2016 美国宾夕法尼亚大学，助理研究员
2009-2014 美国宾夕法尼亚大学，博士后
2004-2009 北京大学，病理生理学，博士（导师：管又飞教授）
1999-2004 山西医科大学，临床医学，学士

奖励和荣誉
2018 “兴辽英才计划”科技创新领军人才（辽宁特聘教授）
2017 大连市高层次人才（地方级领军人才）
2015 美国心脏协会杰出研究奖
2012 国际花生四烯酸大会青年学者奖

学术及社会任职
中国生理学会整合生理学专业委员会委员
中国生理学会青年工作委员会委员
中国细胞生物学学会生物节律分会委员
美国心脏协会(AHA)会员
美国生物节律协会(SRBR)会员
中国生理学会会员
中国细胞生物学会会员
中国病理生理学会会员
大连医科大学生物医学伦理委员会委员
大连医科大学基础医学学位评定分委员会委员
Frontiers in Pharmacology (Editorial Board)
Journal of Pharmacological Reports (Editorial Board)
PPAR Research (Guest Editor, 2013-14)
Scientific Reports (Editorial Board)
生理学报

发表论文

Jia-Yang Zhang, Shuang Ji, Li-Hong Chen*, Guang-Rui Yang*. Recent advances in renal biological clock. Progress in Physiological Sciences 2019;50(5):386-390
Ting-Ting Jiang#, Shuang Ji#, Guang-Rui Yang, Li-Hong Chen*. Research advances in relationship between biological clock and cardiovascular diseases. Acta Physiologica Sinica 2019;71(05):783-791
Lihong Chen, Guangrui Yang, Tingting Jiang, Soonyew Tang, Tao Wang, Qing Wan, Miao Wang, Garret A. FitzGerald. Myeloid cell mPges-1 deletion attenuates mortality without affecting remodeling after acute myocardial infarction in mice. J Pharmacol Exp Ther. 2019;370(1):18-24
Guangrui Yang*, Lihong Chen*, Jiayang Zhang, Baoyin Ren, Garret A FitzGerald. Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions. JCI Insight 2019 Apr 11;5(10):e125133
Hu Xu, Shengnan Du, Bingying Fang, Chaojie Li, Xiao Jia, Wen Su, Nanping Wang, Feng Zheng, Lihong Chen, Xiaoyan Zhang, JÅ Gustafsson, Youfei Guan. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci USA 2019 Apr 23;116(17):8457-8462
Lihong Chen, Guangrui Yang, Jiayang Zhang, Baoyin Ren, Soonyew Tang, Xuanwen Li, Garret A FitzGerald. Time-dependent hypotensive effect of aspirin in mice. Arterioscler Thromb Vasc Biol 2018;38:2819-2826
Hu Hua, Xuhua Ge, Mengqiu Wu, Chunhua Zhu, Lihong Chen, Guangrui Yang, Yue Zhang, Songming Huang, Aihua Zhang, Zhanjun Jia. Rotenone protects against acetaminophen induced kidney injury by attenuating oxidative stress and inflammation. Kidney Blood Press Res 2018 Aug 10;43(4):1297-1309
Jie Yin, Weiwei Xia, Yue Zhang, Guixia Ding, Lihong Chen, Guangrui Yang, Songming Huang, Zhanjun Jia, Aihua Zhang. Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells. Heart Vessels. 2018 Nov;33(11):1411-1422
Yibo Zhuang, Chenhu Wang, Chunfeng Wu, Dan Ding, Fei Zhao, Caiyu Hu, Wei Gong, Guixia Ding, Yue Zhang, Lihong Chen, Guangrui Yang, Chunhua Zhu, Aihua Zhang, Zhanjun Jia, Songming Huang. Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells. Oncotarget 2018 Jan 12;9(10):9235-9245
Jing Wang, Min Liu, Xiaoyan Zhang, Guangrui Yang, Lihong Chen#. Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins Other Lipid Mediat 2018 Jan;134:1-6
Carsten Skarke, Nicholas F. Lahens, Seth D. Rhoades, Amy Campbell, Kyle Bittinger, Aubrey Bailey, Christian Hoffmann, Randal S. Olson, Lihong Chen, Guangrui Yang, Thomas S Price, Jason H Moore, Frederic D Bushman, Casey S Greene, Gregory R Grant, Aalim M Weljie, Garret A FitzGerald. A Pilot Characterization of the Human Chronobiome. Sci Rep 2017 Dec 7;7(1):17141
Wen Su, Shizheng Huang, Min Gao, Xiaomu Kong, Jan-Åke Gustafsson, Sujuan Xu, Bing Wang, Feng Zheng, Lihong Chen, Nanping Wang, Youfei Guan, Xiaoyan Zhang. Liver X receptor β (LXRβ) increases AQP2protein Level via a post-transcriptional mechanism in renal collecting ducts. Am J Physiol Renal Physiol 2017 Apr 1;312(4):F619-F628
Lihong Chen#. Current trends in PGE2 targeting for anti-inflammatory therapy. Pharm Bioprocess 2016;4(3):048-049
Guangrui Yang, Lihong Chen#. An update of microsomal prostaglandin E synthase (mPGES)-1 and PGE2 receptors in cardiovascular health and diseases. Oxid Med Cell Longev 2016;2016:5249086
Soon Yew Tang, James Monslow, Gregory R Grant, Leslie Todd, Sven-Christian Pawelzik, Lihong Chen, John Lawson, Ellen Puré, Garret A FitzGerald. Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. Circulation 2016 Jul 26;134(4):328-38
Guangrui Yang*, Lihong Chen*, Gregory R Grant, Georgios Paschos, Wen-Liang Song, Erik S Musiek, Vivian Lee, Sarah C McLoughlin, Tilo Grosser, George Cotsarelis, Garret A FitzGerald. Timed expression of Bmal1 influences aging and survival. Science Translational Medicine. Sci Transl Med 2016 Feb 3;8(324):324ra16
Anne M Curtis, Caio T Fagundes, Guangrui Yang, Eva M Palsson-McDermott, Paulina Wochal, Anne F McGettrick, Niamh H Foley, James O Early, Lihong Chen, Hanrui Zhang, Chenyi Xue, Sarah S Geiger, Karsten Hokamp, Muredach P Reilly, Andrew N Coogan, Elena Vigorito, Garret A FitzGerald, Luke AJ O’Neill. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci USA 2015 Jun 9;112(23):7231-7236
Lihong Chen#, Guangrui Yang#. Recent advances in circadian rhythms in cardiovascular system. Frontiers in Pharmacology 2015 Apr 1;6:71
Lihong Chen#, Zhanjun Jia, Guangrui Yang#. PPARs and metabolic syndrome. PPAR Res 2014;2014:832606
Lihong Chen, Guangrui Yang, James Monslow, Leslie Todd, David P Cormode, Jun Tang, Gregory R Grant, Jonathan H DeLonge, Soon Yew Tang, John A Lawson, Ellen Pure, Garret A FitzGerald. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci USA 2014;111(18):6828-6833
Lihong Chen#, Guangrui Yang#. PPARs integrate the mammalian clock and energy metabolism. PPAR Res 2014;2014:653017
Lihong Chen, Guangrui Yang, Xiufeng Xu, Gregory Grant, John A Lawson, Mohammad Bohlooly-Y, Garret A FitzGerald. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation 2013;127(2):233-243
Lihong Chen, Guangrui Yang, Tilo Grosser. Prostanoids and inflammatory Pain. Prostaglandins Other Lipid Mediat. 2013;104-105:58-66 [one of the 5 most highly cited papers]
Lihong Chen, Yifei Miao, Yahua Zhang, Dou Dou, Limei Liu, Xiaoyu Tian, Guangrui Yang, Dan Pu, Xiaoyan Zhang, Jihong Kang, Yuansheng Gao, Shiqiang Wang, Matthew D Breyer, Nanping Wang, Yi Zhu, Yu Huang, Richard M Breyer, Youfei Guan. Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor pesponse via decreasing arterial contractility. Arterioscler Thromb Vasc Biol 2012;32(12):3024-3032
Yunfeng Zhou, Xiaomu Kong, Pan Zhao, Hang Yang, Lihong Chen, Jing Miao, Xiaoyan Zhang, Jichun Yang, Jie Ding, Youfei Guan. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney International 2011;79(12):1302-1311
Miao Wang, Kaori Ihida-Stansbury, Devashish Kothapalli, Mathieu C Tamby, Zhou Yu, Lihong Chen, Gregory Grant, Yan Cheng, John A Lawson, Richard K Assoian, Peter L Jones, Garret A FitzGerald. Microsomal prostaglandin E2 synthase-1 modulates the response to vascular injury. Circulation. 2011;123(6):631-639
Fenling Fan, Aiqun Ma, Youfei Guan, Jianhua Huo, Zhi Hua, Hongyan Tian, Lihong Chen, Sen Zhu, Lihong Fan. Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term. Int J Cardiol. 2011;147(1):58-65
Dongjuan Zhang, Hang Yang, Xiaomu Kong, Kang Wang, Xuan Mao, Xianzhong Yan, Yuan Wang, Siqi Liu, Xiaoyan Zhang, Jing Li, Lihong Chen, Jing Wu, Mingfen Wei, Jichun Yang, Youfei Guan. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. Am J Physiol Endocrinol Metab. 2011;300(2):287-295
Dongjuan Zhang, Lihong Chen, Yahua Zhang, Guangrui Yang, Dou Dou, Yuansheng Gao, Xiaoyan Zhang, Xiaomu Kong, Pan Zhao, Dan Pu, Mingfen Wei, Matthew D Breyer, Youfei Guan. Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1. Acta Pharmacol Sin. 2010;31(10):1284-1292
Fenling Fan, Sen Zhu, Lihong Chen, Yuliang Zou, Lihong Fan, Jihong Kang, Aiqun Ma, Youfei Guan. Role of PGE2 and its receptors in the process of the ductus arteriosus maturation and functional closure in rabbit. Clin Exp Pharmacol Physiol. 2010;37(5-6):574-580

特邀报告和学术会议代表

2019整合生理与营养健康专题研讨会, 中国, 大连, 2019年11月23日 (Invited Lecture)
肾脏代谢疾病与免疫研讨大会, 中国, 大连, 2019年8月31日-9月2日 (Invited Lecture, Session co-chair)
2019 Symposium on Cardiovascular Physiology of Chinese Association for Physiological Sciences. Taiyuan, China. Aug 20-21, 2019 (Invited Lecture)
2018多不饱和脂肪酸代谢与疾病国际研讨会, 中国, 大连, 2019年10月30日-11月1日 (Invited Lecture)
The 14th Receptor Society of Chinese Association of Pathophysiology Conference. Wuxi, China. Oct 25-26, 2018 (Session co-chair)
基因动物工程和生物医学国际研讨会, 中国, 大连, 2018年9月10-12日 (Invited Lecture)
2018年辽宁心血管疾病年会, 中国, 大连, 2018年8月31-9月2日 (Invited Lecture)
Asia-Pacific Diabetes and Obesity Study Group (APDO) Symposium 2018. Kobe, Japan. Oct 8-9, 2018 (Invited Lecture)
The 13th Ice City Congress of Cardiology. Harbin, China. Aug 9-12, 2018 (Session co-chair)
The International Society of Nephrology Frontiers Meetings 2018, Tokyo, Japan. Feb 22-26, 2018 (poster presentation, top 10%)
American Heart Association Scientific Sessions. Anaheim, California, USA. Nov 11-15, 2017 (poster presentation)
The 28th Great Wall International Congress of Cardiology. Beijing, China. Oct 12-15, 2017 (oral presentation)
第十三届中国病理生理学会核受体会议, 中国, 大连, 2017年10月28-29日 (Invited Lecture)
The 19th Scientific Annual Congress of Chinese Society of Cardiology. Taiyuan, China. Sep 15, 2017 (Invited Lecture)
The 15th International Atrial Affiliation Conference. Dalian, China. Jul 25-26, 2017 (Invited Lecture)
第三届整合医学和医学学科建设高端研讨会, 中国, 大连, 2016年12月14日 (Session co-chair)
2016脂代谢与生物能学国际学术研讨会, 中国, 大连, 2016年7月1-3日 (Invited Lecture)
整合生理学学术研讨会, 中国, 大连, 2016年6月4日 (Invited Lecture)
American Heart Association Scientific Sessions. Orlando, FL, USA. Nov 7-12, 2015 (poster presentation)
13th International Bioacitive Lipids Conference in Cancer, Inflammation and Related Diseases. San Juan, Puerto Rico, USA, Nov 3-6, 2013 (poster presentation)
American Pain Society 32nd Annual Scientific Meeting, New Orleans, Louisiana, USA, May 8-11, 2013 (poster presentation)
Arteriosclerosis, Thrombosis and Vascular Biology 2012 Scientific Sessions, Chiargo, Illinois, USA. Apr 18-20, 2012 (poster presentation)
The 14th International Winter Eicosanoid Conference, Baltimore, Maryland, USA. Mar 11-14, 2012 (oral presentation)
High Blood Pressure Research 2010 Scientific Sessions, Washington DC, USA. Oct 13-16, 2010 (poster presentation)

发表专著

《肾脏病学》, “一氧化氮”章节, 王海燕主编（第三版）, 人民卫生出版社, 2008
《动脉粥样硬化》, “花生四烯酸及其衍生物”章节, 姜志胜主编, 科学出版社, 2018

高路

教授，博士生导师。国家“优青”，海军军医大学生理学教研室主任，上海市“东方学者”特聘教授，上海市“优秀学术带头人”、上海市卫生系统“优秀学科带头人”、上海市教委“曙光学者”。中国生理学会理事，中国生理学会生殖科学专业委员会副主任委员兼秘书长，中国生理学会青年工作委员会副主任委员；中国妇幼保健协会生育力保存专业委员会常委；上海市生理学会常务理事。

学习和工作经历
2017.09-至今：海军军医大学基础部生理学教研室主任，教授
2017.01-2017.08：第二军医大学基础部生理学教研室主任，副教授
2014.12-2016.12：第二军医大学基础部生理学教研室副主任，副教授
2015.01-2015.04：美国德克萨斯大学西南医学中心高级访问学者
2013.07-2014.07：美国德克萨斯大学西南医学中心讲师
2012.02-2013.06：美国德克萨斯大学西南医学中心博士后
2010.07-2017.08：第二军医大学基础部生理学教研室副教授
2007.07-2010.06：第二军医大学基础部生理学教研室讲师
2002.09-2007.06：第二军医大学基础部生理学教研室硕士、博士研究生
1997.09-2002.06：第二军医大学临床医学系本科

奖励和荣誉
2019年：军队科技进步二等奖（第二完成人）
2019年：上海市“育才奖”
2018年：上海市医学科技奖一等奖（第二完成人）
2018年：上海市“青年五四奖章”
2018年：海军军医大学“吴孟超式”优秀青年
2018年：海军级教学成果奖
2017年：美国比尔梅琳达盖茨基金会“全球健康学术旅行奖”
2016年：优秀党务工作者
2016年：长三角生理学高峰论坛暨“两省一市”生理学学术年会一等奖
2015年：荣立三等功
2010年：上海市生理科学会青年论文交流会三等奖
2009年：中国生理学会张锡钧基金会第十届青年优秀生理学学术论文三等奖
2008年：全军优秀博士学位论文；第二军医大学优秀博士学位论文
2006年：上海—联合利华研究与发展基金奖学金

发表论文

Peng JY, Zhou YH, Zhang ZY, Wang ZM, Gao LT, Zhang X, Fang Z, Li GY, Chen HY, Yang HX, Gao L. (2018) The Detrimental Effects of Glucocorticoids Exposure during Pregnancy on Offspring’s Cardiac Functions Mediated by Hypermethylation of Bone Morphogenetic Protein-4. Cell Death Dis, 9(8):834
Hu TX, Guo X, Wang G, Gao L, He P, Xia Y, Gu H, Ni X. (2017) MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta. Placenta, 52:33-40
Mendelson CR, Montalbano AP, Gao L. (2017) Fetal-to-maternal signaling in the timing of birth. J Steroid Biochem Mol Biol, 170:19-27
Gao L, Wu TW, Ni X. (2016) Gas transmitters in female reproductive system. Acta physiologica Sinica, 68(5):611-620
Gao L, Wang G, Liu WN, Kinser H, Franco HL, Mendelson CR. (2016) Reciprocal Feedback Between miR-181a and E 2/ERα in Myometrium Enhances Inflammation Leading to Labor. J Clin Endocrinol Metab, 101(10):3646–3656 (共同通讯作者)
Liu W, Xu C, You X, Olson DM, Chemtob S, Gao L, Ni X. (2016) Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways. PLoS One, 11(4):e0152838 (共同通讯作者)
Hu TX, Wang G, Guo XJ, Sun QQ, He P, Gu H, Huang Y, Gao L, Ni X. (2016) MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts. Placenta, 39:101-110 (共同通讯作者)
Xi H, An R, Li L, Wang G, Tao Y, Gao L. (2016) Myeloma bone disease: Progress in pathogenesis, Progress in Biophysics and Molecular Biology, 122(2):149-155
Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu JM, O'Malley BW and Mendelson CR. (2015) Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. Journal of Clinical Investigation, 125(7):2808-2824
Renthal NE, Williams KC, Montalbano A, Chen CC, Gao L and Mendelson CR. (2015) Molecular Regulation of Parturition: A Myometrial Perspective. Cold Spring Harb Perspect Med, 5(11):a023069
Li Y, He P, Sun Q, Liu J, Gao L, You X, Gu H, Ni X. (2013) Reduced Expression of 15-Hydroxy Prostaglandin Dehydrogenase in Chorion during Labor Is Associated with Decreased PRB and Increased PRA and GR Expression. Am J Pathol, 182(5):1585-1594
Xu B, Gao L, Wang L, Tang G, He M, Yu Y, Ni X, Sun Y. (2013) Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. Br J Cancer, 109(5):1279-1286 (共同第一作者)
Tao Y, Gao L, Wu X, Wang H, Yang G, Zhan F, Shi J. (2013) Down-Regulation of 11beta-Hydroxysteroid Dehydrogenase Type 2 by Bortezomib Sensitizes Jurkat Leukemia T Cells against Glucocorticoid-Induced Apoptosis. PLoS One, 8:e67067 (共同第一作者)
Gao L, Tao Y, Hu T, Liu W, Xu C, Liu J, You X, Gu H, Ni X. (2012) Regulation of Estradiol and Progesterone Production by CRH-R1 and -R2 Is through Divergent Signaling Pathways in Cultured Human Placental Trophoblasts. Endocrinology, 153(10):4918-4928
Gao L, Lv CM, Xu C, Li Y, Cui XR, Gu H, Ni X. (2012) Differential Regulation of Glucose Transporters Mediated by CRH Receptor Type 1 and Type 2 in Human Placental Trophoblasts. Endocrinology, 153(3):1464-1471
You X, Gao L, Liu J, Xu C, Liu C, Li Y, Hui N, Gu H, Ni X. (2012) CRH Activation of Different Signaling Pathways Results in Differential Calcium Signaling in Human Pregnant Myometrium before and during Labor. J Clin Endocrinol Metab, 97(10):E1851-E1861
Xu C, Gao L, You XJ, Dai L, Li Y, Gu H, Slater DM, Olson DM, Ni X. (2011) Corticotropin-Releasing Hormone Acts on CRH-R1 and -R2 to Differentially Modulate the Expression of Large Conductance Calcium-Activated Potassium Channels in Human Pregnant Myometrium. Endocrinology, 152(11):4406-4417 (共同第一作者)
You XJ, Xu C, Lu JQ, Zhu XY, Gao L, Cui XR, Li Y, Gu H, Ni X. (2011) Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PLoS One, 6:e23788
Xu C, You X, Gao L, Zhang L, Hu R, Hui N, Olson DM, Ni X. (2011) Expression of ATP-sensitive potassium channels in human pregnant myometrium. Reprod Biol Endocrinol, 9:35
Tao Y, Shi JM, Zhang YX, Gao L, Zhan FH. (2011) [Expression of 11beta-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity]. Journal of experimental hematology, 19(1):109-113

会议报告

第90届国际生理学大会，口头报告（中国北京，2016.9）
长三角生理学高峰论坛暨“两省一市”生理学学术年会，口头报告（中国上海，2016.4）
第63届国际生殖科学大会，口头报告（加拿大蒙特利尔，2016.3）
第1届中国生理学会生殖科学学术年会，分会场主席暨口头报告（中国西安，2015.10）
第19届美国德州生殖科学论坛，口头报告（美国休斯敦，2013.4）
中国动物学会生殖生物学分会第十三次学术研讨会，口头报告（中国武夷山，2011.11）

发表专著

《医学发育生物学》（第四版）（科学出版社，2018）
《生理科学进展》（高等教育出版社，2014）
《医学发育生物学》（第三版）（科学出版社，2012）
《胎儿发育生理学》（高等教育出版社，2008）
《医学发育生物学》（第二版）（科学出版社，2007）

孔炜

国家杰出青年基金获得者，北京大学医学部生理与病理生理系；Tel: 010-82805594；E-mail: kongw@bjmu.edu.cn

学习和工作经历
1990.09-1995.07 本科同济医科大学临床医疗系
1995.09-2000.07 硕博连读研究生华中科技大学同济医学院病理生理学
2001.02-2003.07 博士后美国华盛顿大学
2003.08-2005.10 博士后美国纽约大学医学院
2005.12-2010.08 北京大学医学部生理学与病理生理学系副教授
2010.08-至今北京大学医学部生理学与病理生理学系教授
2016.12- 北京大学医学部生理学与病理生理学系主任

奖励和荣誉
2007年：教育部新世纪优秀人才
2007年：北京市科技新星
2008年：霍英东教育基金会第十一届高等院校青年教师优选基金奖
2009年：北京大学医学部优秀青年学者
2009年：北京大学基础医学院优秀SCI论文一等奖, 北京大学医学部优秀SCI论文奖
2009年：获北京大学医学部优秀教师称号
2010年：北京大学基础医学院优秀SCI论文一等奖, 北京大学医学部优秀SCI论文奖
2011年：北京大学绿叶生物医药杰出青年学者奖
2012年：北京市优秀人才培养资助计划
2012年：国家杰出青年基金
2015年：科技部·比尔盖茨基金会创新大挑战-青年科学家
2016年：第十四届中国青年科技奖
2018年：科技部中青年科技创新领军人才

学术及社会任职
国际基质生物学会理事(2016-)
中国生理学会“基质生物学”专业委员会首任主任委员(2015-2017)
编委: Matrix Biology (IF 8.1); Cardiovascular Res (IF 6.5); J Mol Cell Cardiol (IF 5); Current Vascular Pharmacology (IF 2.9); Current Angiogenesis;
«基础医学与临床»编委
中国医学前沿杂志（电子版）编委
教育部分子心血管重点实验室副主任
中国生理学会常务理事及青年工作委员会主任委员

发表论文

She S, Wu X, Zheng D, Pei X, Ma J, Sun Y, Zhou J, Nong L, Guo C, Lv P, Song Q, Zheng C, Liang W, Huang S, Li Q, Liu Z, Song Z, Li Y, Zhang Y, Kong W, You H, Xi J, Wang Y. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. J Hepatol. 2020 Mar;72(3):506-518
Cong X, Kong W*. Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease. Cell Signal. 2020 Feb;66:109485 [Review]
Qi L, Chi X, Zhang X, Feng X, Chu W, Zhang S, Wu J, Song Y, Zhang Y, Kong W, Yu Y, Zhang H. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell Death Dis. 2019 Nov 26;10(12):890
Huang SM, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP, Wang J. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019 Dec 3;91(23):14936-14942
Zhou B, Li W, Zhao G, Yu B, Ma B, Liu Z, Xie N, Fu Y, Gong Z, Dai R, Zhang X, Kong W. Rapamycin prevents thoracic aortic aneurysm and dissection in mice. J Vasc Surg. 2019 Mar;69(3):921-932
Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y, Fu Y. The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C762-C775
Liu M, Li L, Zhu J, He C, Xu Q, Sun A, Kong W, Li W, Zhang X. Biochem Biophys Res Commun. 2019 May 7;512(3):498-504
Liu X, Li J, Liao J, Wang H, Huang X, Dong Z, Shen Q, Zhang L, Wang Y, Kong W, Liu G, Huang W. Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice. Atherosclerosis. 2019 Mar;282:100-109
Liu M, Li L, Zhu J, He C, Xu Q, Sun A, Kong W, Li W, Zhang X. Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126-3p mediated activation of MAPK/ERK signalling pathway. Biochem Biophys Res Commun. 2019 May 7;512(3):498-504
Zhang D, Wang X, Chen S, Chen S, Yu W, Liu X, Yang G, Tao Y, Tang X, Bu D, Zhang H, Kong W, Tang C, Huang Y, Du J, Jin H. Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation. Clin Sci (Lond). 2019 Oct 30;133(20):2045-2059
Sun L, Pang Y, Wang X, Wu Q, Liu H, Liu B, Liu G, Ye M, Kong W, Jiang C. Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters. Acta Pharm Sin B. 2019 Jul;9(4):702-710
Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, Liu H, Pang Y, Kong W, Zhang T, Wang X, Jiang C. Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. EBioMedicine. 2019 Nov;49:291-304
Shao F, Miao Y, Zhang Y, Han L, Ma X, Deng J, Jiang C, Kong W, Xu Q, Feng J, Wang X. B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinemia-aggravated abdominal aortic aneurysm. Cardiovasc Res. 2019 Nov 29;cvz288
Zhang X, Zhang Y, Wang P, Zhang SY, Dong Y, Zeng G, Yan Y, Sun L, Wu Q, Liu H, Liu B, Kong W, Wang X, Jiang C. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism. Cell Metab. 2019 Nov 5;30(5):937-951
Tang RZ, Zhu JJ, Yang FF, Zhang YP, Xie SA, Liu YF, Yao WJ, Pang W, Han LL, Kong W, Wang YX, Zhang T, Zhou J. DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis. J Mol Cell Cardiol. 2019 Jan 16;128:11-24
Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, Kong W*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation. 2018 Jul 3;138(1):48-63 (Editorial comment)
Zhang D, Wang X, Tian X, Zhang L, Yang G, Tao Y, Liang C, Li K, Yu X, Tang X, Tang C, Zhou J, Kong W, Du J, Huang Y, Jin H. The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation. Front Immunol. 2018 Apr 30;9:882
Wang S, Liu Y, Zhao G, He L, Fu Y, Yu C, Wang Z, Zhao T, Cao F, Gao Y, Kong W*, Zheng J*. Postnatal deficiency of ADAMTS1 ameliorates thoracic aortic aneurysm and dissection in mice. Exp Physiol. 2018 Dec;103(12):1717-1731
Ma B, Yao F, Xie N, Mao C, Liu F, Gong Z, Zhao G, Liu Z, Cai Z, Yu F, Dai R, Chen Z, Wang L, Xu Q, Kong W*, Fu Y*. Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage. J Mol Cell Cardiol. 2018 Aug;121:69-80
Yao F, Yu P, Li Y, Yuan X, Li Z, Zhang T, Liu F, Wang Y, Wang Y, Li D, Ma B, Shu C, Kong W, Zhou B, Wang L. Histone Variant H2A.Z is Required for the Maintenance of Smooth Muscle Cell Identity as Revealed by Single-Cell Transcriptomics. Circulation. 2018 Nov 13;138(20):2274-2288
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W*. COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity. Cell Death Dis. 2018 Jun 4;9(6):676
He L, Fu Y, Deng J, Shen Y, Wang Y, Yu F, Xie N, Chen Z, Hong T, Peng X, Li Q, Zhou J, Han J, Wang Y, Xi J, Kong W*. Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1616-1631
Liu XJ, Wu XY, Wang H, Wang SX, Kong W, Zhang L, Liu G, Huang W. Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk. FASEB J. 2018 Oct;32(10):5550-5562
Li L, Zhao Q, Kong W*. Extracellular matrix remodeling and cardiac fibrosis. Matrix Biol. 2018 Aug;68-69:490-506
Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W*. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018 Jan 2;9(1):11
Gao Y, Wang Z, Zhang Y, Liu Y, Wang S, Sun W, Guo J, Yu C, Wang Y, Kong W, Zheng J. Naringenin inhibits NG-nitro-L-arginine methyl ester-induced hypertensive left ventricular hypertrophy by decreasing angiotensin-converting enzyme 1 expression. Exp Ther Med. 2018 Aug;16(2):867-873
Fu Y, Wang X, Kong W*. Hyperhomocysteinemia and Vascular Injury: The Advance of Mechanisms and Drug Targets. Br J Pharmacol. 2018 Apr;175(8):1173-1189
Xie SA, Zhang T, Wang J, Zhao F, Zhang YP, Yao WJ, Hur SS, Yeh YT, Pang W, Zheng LS, Fan YB, Kong W, Wang X, Chiu JJ, Zhou J. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. Biomaterials. 2018 Feb;155:203-216
Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L, Xu Q, Kong W*. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017 Dec 8;121(12):1331-1345
Kong W, Du J, Zhu Y, Dong E. Basic and Translational Vascular Research in China: Past, Present, and Future. Circ Res. 2017 Aug 4;121(4):335-337
Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W*. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1698-1709
Fu Y, Kong W*. Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease. Curr Vasc Pharmacol. 2017;15(3):186-196
Jia Y, Kong W*. ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):176-178
Yu H, Jia Q, Feng X, Chen H, Wang L, Ni X, Kong W. Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells. Int J Biochem Cell Biol. 2017 Aug 30;91(Pt A):37-44
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, Xu Q. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017 Jul 17;7(1):5590
Liu J, Jia X, Jia S, Qin X, Zhang T, Liu L, Li H, Rong D, Zhou Z, Song Y, Zuo S, Duan C, Wu Z, Wei R, Ge Y, Wang X, Kong W, Xu X, Khalil RA, Huo Y, Guo W. Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults. Sci Rep. 2017 Nov 6;7(1):14547
Wang H, Wu W, Duan J, Ma M, Kong W, Ke Y, Li G, Zheng J. Cardioprotection of ischemic preconditioning in rats involves upregulating adiponectin. J Mol Endocrinol. 2017 May;58(4):155-165
Fu Y, Gao C, Liang Y, Wang M, Huang Y，Ma W，Li T，Jia Y，Yu F，Zhu W，Cui Q，Li Y，Xu Q，Wang X, Kong W*. Shift of Macrophage Phenotype due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. Circ Res. 2016 Jul 8;119(2):261-276 (Cover story with editorial comment)
Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu S, Xu Q, Zhu Y, Guan Y, Wang X, Kong W*. Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):108-121
Yang N, Yu F, Shao G, Fu Y, Kong W*. The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy. Biochem Biophys Res Commun. 2016 Oct 28;479(4):728-735
Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W*. Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence. Biochem Biophys Res Commun. 2016 Sep 16;478(2):1006-1013
Ma W, Zhang L, Zeng P, Huang C, Li J, Geng B, Yang J, Kong W, Zhou X, Cui Q. An analysis of human microbe-disease associations. Brief Bioinform. 2017 Jan;18(1):85-97
Zhang J, Wang J, Wei Y, Gao C, Chen X, Kong W, Kong D, Zhao Q. ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro. Colloids Surf B Biointerfaces. 2016 Oct 1;146:280-288
Simpson RM, Hong X, Wong MM, Karamariti E, Issa Bhaloo S, Warren D, Kong W, Hu Y, Xu Q. Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage. Stem Cells. 2016 2016 May;34(5):1225-1238
Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W*. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-914 (with editorial comment)
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W*. ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-1201 (with editorial comment)
Zhang K, Li T, Fu Y, Cui Q, Kong W*. Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. PLoS One. 2015 Oct 23;10(10):e0140888
Wei R, Liu LS, Wang LW, Li YB, Zhang T, Liu J, Zuo SW, Jia SH, Song YX, Wu ZY, Duan C, Ge YY, Li HB, Xiong J, Jia X, Wang X, Kong W, Xu XP, Guo W, Huo Y. Association of Resting Heart Rate with Infrarenal Aortic Diameter: A Cross Sectional Study in Chinese Hypertensive Adults Eur J Vasc Endovasc Surg. 2015 Dec;50(6):714-721
Zhao Y, Zhao MM, Cai Y, Zheng MF, Sun WL, Zhang SY, Kong W, Gu J, Wang X, Xu MJ. Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation. Kidney Int. 2015 Oct;88(4):711-721
Zhang L, Yu F, Wang L, Zheng J, Du Y, Huang Y, Liu B, Wang X, Kong W*. ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo. Sci China Life Sci. 2015 Jul;58(7):674-681
Sun W, Pang Y, Liu Z, Sun L, Liu B, Xu M, Dong Y, Feng J, Jiang C, Kong W*, Wang X*. Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. J Mol Cell Cardiol. 2015 Apr;81:96-106
Li J, Gao C, Wang Y, Ma W, Tu J, Wang J, Chen Z, Kong W, Cui Q. A bioinformatics method for predicting long noncoding RNAs associated with vascular disease. Sci China Life Sci. 2014 Aug;57(8):852-857
Luo H, Liu B, Hu J, Wang X, Zhan S, Kong W*. Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis. Cerebrovasc Dis. 2014 Jun 4;37(5):313-322
Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. Biochem Biophys Res Commun. 2014 Oct 18;454(1):137-143
Gao F, Chambon P, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling. Biochem Biophys Res Commun. 2014 Oct 24;454(1):245-250
Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ, Wang X. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 1;101(2):297-305
Gao YX, Yu CA, Lu JH, Gao HM, Li G, Kong W*, Zheng J*. ADAMTS-7 expression increases in the early stage of angiotensin II-induced renal injury in elderly mice. Kidney Blood Press Res. 2013;38(1):121-1231
Huang Y, Xia J, Zheng J, Geng B, Liu P, Yu F, Liu B, Zhang H, Xu M, Ye P, Zhu Y, Xu Q, Wang X, Kong W*. Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy. Basic Res Cardiol. 2013 Sep;108(5):374
Zheng J, Kong W*. Noninvasive imaging of coronary artery disease--myth or reality? Circ J. 2013;77(6):1409-1410
Li Y, Zhang H, Jiang C, Xu M, Pang Y, Feng J, Xiang X, Kong W, Xu G, Li Y, Wang X. Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue. J Biol Chem. 2013 Apr 5;288(14):9583-9592
Dai XY, Zhao MM, Cai Y, Guan QC, Zhao Y, Guan Y, Kong W, Zhu WG, Xu MJ, Wang X. Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int. 2013 Jun;83(6):1042-1051
Ma K, Lv S, Liu B, Liu Z, Luo Y, Kong W, Xu Q, Feng J, Wang X. CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE-/- mice. Cardiovasc Res. 2013 Feb 1;97(2):349-359
Du Y, Gao C, Liu Z, Wang L, Liu B, He F, Zhang T, Wang Y, Wang X, Xu M, Luo GZ, Zhu Y, Xu Q, Wang X, Kong W*. Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2580-2588
Liu Z, Luo H, Zhang L, Huang Y, Liu B, Ma K, Feng J, Xie J, Zheng J, Hu J, Zhan S, Zhu Y, Xu Q, Kong W*, Wang X*. Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice. Circ Res. 2012 Oct 26;111(10):1261-1273. (Cover Story)
Zhang D, Chen Y, Xie X, Liu J, Wang Q, Kong W*, Zhu Y*. Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol. 2012 Oct;53(4):487-496
Kong W, Zhu Y. The Pleiotropic Effects of Statins in the Prevention of Atherosclerosis: Editorial to: "Simvastatin Suppresses Apoptosis in Vulnerable Atherosclerotic Plaques Through Regulating the Expression of p53, Bcl-2 en Bcl-xL" by Weiwei Qin et al. Cardiovasc Drugs Ther. 2012 Feb;26(1):5-7
Kong W*. Matrix metalloproteinase-9 vs. troponin T. The sooner the better? Circ J. 2011;75(12):2757-2758
Zhao G, Xu MJ, Zhao MM, Dai XY, Kong W, Wilson GM, Guan Y, Wang CY, Wang X. Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. Kidney Int. 2012 Jul;82(1):34-44
Zhou Z, Sun W, Liang Y, Gao Y, Kong W, Guan Y, Feng J, Wang X. Fenofibrate inhibited the differentiation of T helper 17 cells in vitro. PPAR Res. 2012;2012:145654
Zhou Z, Liang Y, Gao Y, Kong W, Feng J, Wang X. Fenofibrate enhances the in vitro differentiation of foxp3(+) regulatory T cells in mice. PPAR Res. 2012;2012:529035
Zhang D, Xie X, Chen Y, Hammock BD, Kong W, Zhu Y. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Circ Res. 2012 Mar 16;110(6):808-817
Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu CJ, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W*, Wang X. Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2. Circ Res. 2011 Apr 15;108(8):917-928
Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. A Novel Mechanism of {gamma}/{delta} T-Lymphocyte and Endothelial Activation by Shear Stress: The Role of Ecto-ATP Synthase {beta} Chain. Circ Res. 2011 Feb 18;108(4):410-417
Zhao MM, Xu MJ, Cai Y, Zhao G, Guan Y, Kong W, Tang C, Wang X. Mitochondrial O2.- promoting p65 nuclear translocation mediates high-phosphate-induced vascular calcification in vitro and in vivo. Kidney Int. 2011 May;79(10):1071-1079
Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu CJ, Zhu Y, Gao Y, Xu Q, Kong W*, Wang X*. Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting with α7β1 Integrin. Circ Res. 2010 Feb 19;106(3):514-525 (with editorial)

李于

研究员，博士生导师，糖尿病与非酒精性脂肪性肝病研究专家，获得国家杰出青年科学基金。中科院卢嘉锡国际团队成员，美国糖尿病协会青年学者旅行奖，波士顿大学基础医学奖。目前是中国病理生理学会内分泌与代谢专业委员会副秘书长，中国生物物理学会代谢生物学会理事、中华医学会糖尿病学分会糖尿病基础研究与转化医学学组委员。担任Nutrition & Metabolism副主编。现任中国科学院上海营养与健康研究所研究员，中国科学院上海营养与健康研究所学术委员会委员及动物管理和使用委员会主任，信号转导与代谢课题组组长。主要的研究内容是围绕机体营养感应及代谢调控在胰岛素抵抗、肝脏脂质代谢紊乱、肥胖等重大代谢性疾病发生发展和治疗中的作用开展系列研究。先后主持和参与国家自然科学基重点研发计划，国家自然科学基金，中国科学院战略性先导项目，上海市科委项目。近年来在糖尿病，肝脏，肥胖多领域国际顶级核心期刊（如Cell Metabolism, Nature Communications, Hepatology, Gastroenterology, Diabetes, Br J Pharmacol, J Bio Chem）上发表文章30余篇，应邀在国际和国内学术大会上做学术报告50多次。

发表论文

Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*. CREBZF as a key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. Hepatology. 2020 Apr;71(4):1421-1436
Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene. Nat Commun. 2019;10(1):623
Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex. Cell Metabolism. 2019;29(3):653-667
Yang Y#, Ma F#, Liu Z, Su Q, Liu Y, Liu Z, Li Y*. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3. Journal of Biological Chemistry. 2019;294(3):772-782
Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Experimental and Molecular Medicine. 2019;51(9):103
Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang J, Chen S, Ye RD, Li Y, Le Y*. Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization. Diabetes. 2019;68(6):1130-1142
Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. Molecular Metabolism. 2019;20:138-148
Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF couples insulin to lipogenesis by inhibiting Insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology. 2018;68(4):1361-1375
Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M*. DEPTOR suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. Hepatology. 2018;68(2):496-514
Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X*. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. British Journal of Pharmacology. 2018;175(2):374-387
Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin XM*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply. Autophagy. 2018;14(10):1779-1795
Cui A, Hu Z, Han Y, Yang Y, Li Y*. Optimized analysis of In vivo and in vitro hepatic steatosis. Journal of Visualized Experiments. 2017;e55178
Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y*. Fasting-induced hormonal regulation of lysosomal function. Cell Res. 2017;27:748-763
Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1. Hepatology. 2016;64(2):425-438
Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 increases fatty acid oxidation to attenuate hepatic steatosis in mice through peroxisome proliferator-activated receptor alpha. Diabetes. 2016;65(7):1904-1915
Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014;146:539-549
Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. Journal of Biological Chemistry. 2013;288:10490-10504
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M*. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metabolism. 2011;13:376-388
Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal. 2011;25:1664-1679

梁晓雯

学习和工作经历
2015.10-至今研究员，澳大利亚昆士兰大学医学院Diamantina研究所治疗研究中心
2015.04-2015.09 助理研究员，澳大利亚昆士兰大学医学院治疗研究中心
2011.09-2015.04 临床医学博士，澳大利亚昆士兰大学医学院
2008.08-2011.07 药理学硕士，南京中医药大学
2004.09-2008.07 药学学士，南京中医药大学

奖励和荣誉
2018.12 优秀摘要奖，澳洲胃肠病学会
2018.11 Gallipoli奖金，澳洲胃肠病学会
2016.07 欧洲消化病年会“最佳壁报奖”
2016.07 澳大利亚弗雷泽基金会2016年弗雷泽医学研究会议奖
2016.06 欧洲显微镜学会“最佳青年科学家奖”
2016.06 2015年昆士兰大学杰出毕业论文校长奖

发表论文

Lu Zhang, Huilan Su, Haolu Wang, Qian Li, Xiao Li, Chuanqing Zhou, Jia Xu, Yimin Chai, Xiaowen Liang, Liqin Xiong, Chunfu Zhang. Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter. Theranostics 2019;9(7):1893-1908
Wenjin Xiao, Thomas I P Green, Xiaowen Liang (co-first), Rosalia Cuahtecontzi Delint, Guillaume Perry, Michael S Roberts, Kristian Le Vay, Catherine R Back, Raimomdo Ascione, Haolu Wang, Paul R Race, Adam W Perriman. Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chem Sci 2019 Jul 3;10(32):7610-7618
H Yang, RM Villani, H Wang. MJ Simpson, MS Roberts, M Tang, X Liang (corresponding author). The role of cellular reactive oxygen species in cancer chemotherapy. J Exp Clin Cancer Res 2018 Nov 1;37(1):266
H Wang, H Yang, Z Xu, X Liu, MS Roberts, X Liang (corresponding author). Anionic Long-Circulating Quantum Dots for Long-Term Intravital Vascular Imaging. Pharmaceutics 2018;10(4):244
H Wang, X Li, BW Tse, H Yang, CA Thorling, Y Liu, M Touraud, JB Chouane, X Liu, MS Roberts, X Liang (corresponding author). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics 2018;8(5):1227
H He, Y Liu, Z Zhou, C Guo, HY Wang, Z Wang, X Wang, Z Zhang, FG Wu, Wang H, Chen D, Yang D, Liang X (co-corresponding author), Chen J, Zhou S, Liang X, Qian X, Yang Y. A Photo-triggered and photo-calibrated nitric oxide donor: Rational design, spectral characterizations, and biological applications. Free Radic Biol Med 2018 Aug 1;123:1-7
X Luo, H Yang, H Wang, Z Ye, Z Zhou, L Gu, J Chen, Y Xiao, X Liang (co-corresponding author), X Qian, Y Yang. Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells. Anal Chem 2018 May 1;90(9):5803-5809
H He, Y Xia, Y Qi, HY Wang, Z Wang, J Bao, Z Zhang, FG Wu, H Wang, D Chen, D Yang, Liang X (co-corresponding author), J Chen, S Zhou, X Liang, X Qian, Y Yang. A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjug Chem 2018;29(4):1194-1198
H Wang, R Zhang, KR Bridle, A Jayachandran, JA Thomas, W Zhang, J Yuan, ZP Xu, DHG Crawford, X Liang (co-corresponding author), X Liu, MS Roberts. Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Sci Rep 2017 Mar 28;7:45374
X Li, S Teng, Y Zhang, W Zhang, X Zhang, K Xu, H Yao, J Yao, H Wang, X Liang (co-corresponding author), Z Hu. TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. Oncotarget 2017;8(29):47052-47063
X Li, W Zhang, X Zhang, H Wang, K Xu, H Yao, J Yao, X Liang (co-corresponding author), Z Hu. The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy. Oncotarget 2017;8(29):46946-46954
X Li, H Lu, K Xu, H Wang, X Liang (co-corresponding author), Z Hu. Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer 2017;17(1):227
X Liang, H Wang, JE Grice, L Li, X Liu, ZP Xu, MS Roberts. A physiologically based pharmacokinetic model for long-circulating nanoparticles. Nano Letters 2016;16(2):939–945
X Liang, H Wang, Y Zhu, R Zhang, VC Cogger, X Liu, ZP Xu, JE Grice, MS Roberts. Short- and long-term tracking of anionic ultra-small nanoparticles in kidney. ACS Nano 2016;10(1):387–395
H Wang*, X Liang* (co-first author), ZP Xu, DHG Crawford, X Liu, MS Roberts. A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports 2016;6:22293
H Wang*, X Liang* (co-first author), YH Mohammed, JA Thomas, KR Bridle, CA Thorling, JE Grice, ZP Xu, X Liu, DHG Crawford. MS Roberts. Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express 2015;6(3):780-792
X Liang, JE Grice, Y Zhu, D Liu, WY Sanchez, Z Li, DHG Crawford, DGL Couteur, CC Victoria, X Liu, ZP Xu, MS Roberts. Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small 2014;11(14):1711-1720
X Liang, ZP Xu, JE Grice, AV Zvyagin, MS Roberts, X Liu. Penetration of nanoparticles into human skin. Current Pharmaceutical Design 2013;19(35):6353-6366

刘宝华

深圳大学医学部基础医学院/医学中心特聘教授，博士生导师，国家自然科学基金委优秀青年基金获得者，深圳市孔雀B类人才，基础医学院副院长（科研），医学中心执行主任，国家生化工程技术研究中心（深圳）主任，深圳市系统衰老与主动健康重点实验室主任。兼任亚洲衰老研究学会（Asian Society of Aging Research, ASAR）秘书长，中国老年医学学会基础与转化医学分会常务委员、青委副主委，中国老年学和老年医学学会老年病学分会常务委员、衰老基础医学专家委员会副主任委员，中国生物物理学会衰老生物学专业委员会常务委员、副秘书长，中国生理学会基质生物学专业委员会委员，中国细胞生物学会衰老细胞生物学分会常务委员、青年工作委员会委员，中国老年学和老年医学学会抗衰老分会理事，深圳市生物化学与分子生物学会副秘书长。担任《生理学报》编委，国家自然科学基金委“器官衰老与器官退行性变化的机制”重大研究计划撰写专家组成员（2015‒2016），重点、面上及青年基金二审专家（2015‒2019），科技部重点研发计划干细胞和生殖健康专项评审专家（2016‒2019）。从事衰老机制与干预策略研究，获国家自然科学基金委、国家重点研发计划、香港研究资助局、广东省科技厅、深圳市科创委等科研基金资助，以第一或通讯作者在Nature Medicine (2005), Cell Metabolism (2012), Nature Metabolism (2019), Science Advances (2019/2020), Nature Communications (2013/2017), EMBO Journal (2020), Elife (2018/2020), Nucleic Acids Research (2020a/2020b), Aging Cell (2013/2020), Oncogene (2018)等国际期刊发表高水平学术论文。

发表论文 (*Corresponding authorship, #equal contribution)

Meng F#, Qian M#, Peng B#, Peng L, Wang X, Zheng K, Liu Z, Tang X, Zhang S, Sun S, Cao X, Pang Q, Zhao B, Ma W, Songyang Z, Xu B, Zhu WG, Xu X*, Liu B*. Synergy Between SIRT1 and SIRT6 Helps Recognize DNA Breaks and Potentiates the DNA Damage Response and Repair in Humans and Mice. Elife, 2020 Jun 15;9:e55828
Wang M, Wang L, Qian M, Tang X, Liu Z, Lai Y, Ao Y, Huang Y, Meng Y, Shi L, Peng L, Cao X, Wang Z, Qin B, Liu B*. PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. Aging Cell, 2020 Jun;19(6):e13147
Peng L#, Qian M#*, Liu Z, Tang X, Sun J, Jiang Y, Sun S, Cao X, Pang Q, Liu B*. Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research, 2020 May 21;48(9):4992-5005
Sun S#, Qin W#, Tang X#, Meng Y, Hu W, Zhang S, Qian M, Liu Z, Cao X, Pang Q, Zhao B, Wang Z, Zhou Z, Liu B*. Vascular endothelium-targeted Sirt7 gene therapy rejuvenates aging tissues and extends lifespan in Hutchinson-Gilford progeria model. Sci Adv, 2020 Feb 19;6(8):eaay5556
Tang X, Li G, Su F, Cai Y, Shi L, Meng Y, Liu Z, Sun J, Wang M, Qian M, Wang Z, Xu X, Cheng YX, Zhu WG, Liu B*. HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Res, 2020 Apr 6;48(6):2912-2923
Liu Z#, Qian M#, Tang X, Hu W, Sun S, Li G, Zhang S, Meng F, Cao X, Sun J, Xu C, Tan B, Pang Q, Zhao B, Wang Z, Guan Y, Ruan X, Liu B*. SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nat Metab, 2019 Nov;1(11):1141-1156
Ao Y#, Zhang J#, Liu Z, Qian M, Li Y, Wu Z, Sun P, Wu J, Bei W, Wen J, Wu X, Li F, Zhou Z, Zhu WG, Liu B*, Wang Z*. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv, 2019 Mar 20;5(3):eaav5078
Shi L#, Tang X#, Qian M, Liu Z, Meng F, Fu L, Wang Z, Zhu WG, Huang JD, Zhou Z, Liu B*. A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. Oncogene, 2018 Dec;37(49):6299-6315
Qian M#, Liu Z#, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B*. Boosting ATM Activity alleviates ageing and extends lifespan in a mouse model of progeria. Elife, 2018 May 2;7:e34836
Tang X#, Shi L#, Xie N#, Liu Z, Qian M, Meng F, Xu Q, Zhou M, Cao X, Zhu WG, Liu B*. SIRT7 Antagonizes TGF-β Signaling and Inhibits Breast Cancer Metastasis. Nat Commun, 2017 Aug 22;8(1):318
Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z*. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun, 2013;4:1868
Liu B*, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z*. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab, 2012 Dec 5;16(6):738-750

刘慧荣

学历和工作经历
2009-至今教授，首都医科大学生理学与病理生理学系，北京
2002-2009 教授，山西医科大学生理学系，山西太原
2001-2004 博士后，托马斯杰弗逊大学急诊医学部，费城，宾夕法尼亚州，合作研究员
1998-2001 副教授，山西医科大学，生理学系
1995-1998 讲师，山西医科大学生理学系，山西太原
1985-1992 主治医师，山西省太钢总医院，山西太原
1981-1984 助教，长治医学院微生物教研室，山西长治
1999.07 博士，山西医科大学，山西太原生理学
1995.07 硕士，山西医科大学，山西太原免疫学
1981.01 专科，长治医学院，山西长治临床医学

学术及社会任职
Acta Pharmacologica Sinica, Age, Apoptosis, Chemistry of Life, Hypertension, International Journal of Cardiology, JRAAS, Plos One, 生理学报, 生理科学进展

发表论文

Dan Liu, Linguo Wu, Ye Wu, Xin Wei, Wen Wang, Suli Zhang, Ming Yi, Jing Li*, Huirong Liu*, Xinliang Ma. Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. Aging (Albany NY). 2019;11(20):8982-8997
Sun Y, Zhang S, Yue M, Li Y, Bi J, Huirong Liu*. Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis. Cell Death Dis. 2019;10(5):362
Wenli Xu, Ye Wu, Li Wang, Yan Bai, Yunhui Du, Yang Li, Ning Cao, Yuhui Zhao, Youyi Zhang, Huirong Liu*. Autoantibody against beta1-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4+ T cells by up-regulating AMPK-mediated fatty acid oxidation. Cell Death Dis. 2019 Feb 15;10(3):158
Ning Cao, Hao Chen, Yan Bai, Xiaochun Yang, Wenli Xu, Weiwei Hao, Yi Zhou, Jiayin Chai, Ye Wu, Zhaojia Wang, Xiaochen Yi, Linguo Wu, Wen Wang*, Huirong Liu*, Michael LX Fu. β2-adrenergic receptor autoantibodies alleviate myocardial damage induced by β1-adrenergic receptor autoantibodies in heart failure. Cardiovasc Res. 2018 Sep 1;114(11):1487-1498
Li Wang, Yang Li, Na Ning, Jin Wang, Zi Yan, Suli Zhang, Xiangying Jiao, Xiaohui Wang, Huirong Liu*. Decreased autophagy induced by β-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis. Cell Death Dis. 2018;9(3):406
K Wang, Y Yuan, X Liu, B Wayne, L Zuo, X Wang, L Ma, K Jiao, J Shang, W Wang, X Ma, H Liu*. Cardiac specific overexpression of mitochondrial Omi/HtrA2 induces myocardial apoptosis and cardiac dysfunction. Scientific report. 2016;6:37927
Tingting Lv, Yunhui Du, Ning Cao, Suli Zhang, Yulin Gong, Yan Bai, Wen Wang, Huirong Liu*. Proliferation in cardiac fibroblasts induced by β1-adrenoceptor autoanibody and the underlying mechanisms. Sci Rep. 2016 Aug 31;6:32430
L Wang, H Hao, J Wang, X Wang, S Zhang, Y Du, T Lv, L Zuo, Y Li, H Liu*. Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodyies. Cell Death Dis. 2015;6:e1862
Jie Yang, Li Li, Jianyu Shang, Lin Cai, Li Song, Suli Zhang, Hao Li, Xiao Li, Wayne Bond Lau, Xinliang Ma, Huirong Liu*. Angiotensin II Type 1 Receptor Autoantibody as a Novel Negative Regulator of Aldosterone independent of Preeclampsia. J Hypertens. 2015 May;33(5):1046-1056
Ke Wang, Jie Zhang, Jingyi Liu, Jue Tian, Ye Wu, Xiaoliang Wang, Lin Quan, Haibo Xu, Wen Wang, Huirong Liu*. Variations in the Protein Level of Omi/HtrA2 in the Heart of Aged Rats may Contribute to the Increased Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury and Cell Death. Age (Dordr). 2013;35(3):733-746
Zhang S, Zhang X, Yang L, Yan Z, Yan L, Tian J, Li X, Song L, Wang L, Yang X, Zheng R, Lau W, Ma XL, Liu H*. Increased Susceptibility to Metabolic Syndrome in Adult Offspring of Angiotensin Type 1 Receptor Autoantibody-Positive Rats. Antioxid Redox Signal. 2012;17(5):733-743
Zuo L, Bao H, Tian J, Wang X, Zhang S, He Z, Yan L, Zhao R, Ma XL*, Liu HR*. Long-term active immunization with a synthetic peptide corresponding to the second extracellular loop of beta(1)-adrenoceptor induces both morphological and functional cardiomyopathic changes in rats. Int J Cardiol. 2011;149(1):89-94

刘凌波

学习和工作经历
2017.11~至今三级教授、主任医师、博士研究生导师，华中科技大学协和医院血液病研究所
2012.11~2017.10 教授、主任医师、博士研究生导师，华中科技大学协和医院血液病研究所
2003.07~2012.10 副教授，副主任医师、硕士研究生导师，华中科技大学协和医院血液病研究所
1995.08~2003.06 主治医生，讲师，华中科技大学协和医院血液病研究所
198408~199208 武汉市第九医院内科，住院医生
2006.04~2007.06 Research Associate (博士后), Department of Pathology and Laborary Medicine, Medical University of South Carolina, Charleston SC，USA
1998.09~2001.07 华中科技大学同济医学院，博士研究生（内科血液病学）
1992.09~1995.07 华中科技大学同济医学院，硕士研究生（内科血液病学）
1979.09~1984.07 原武汉医学院医疗系，本科生

科研经历
主要研究方向：（1）造血干细胞衰老与干性维持机制（2）白血病干细胞干性维持、衰老抵抗与耐药复发机制。主持各类课题11项，包括5项国家自然科学基金面上项目, 获得总经费300余万元。
2009.01-2011.12 脐带血HSCs扩增的新策略：抑制“ROS-P38MAPK-HSCs衰老”信号通路(国家自然科学基金面上项目，30871097，课题负责人，31.0万)
2012.1-2015.12 下调体外扩增人HSCs过高的mTOR C1活性抑制衰老维持干性（国家自然科学基金面上项目，81170524，课题负责人，50.0万）
2014.01-2017.12 miR34c重启衰老清除急性髓系白血病干细胞与机制研究（国家自然科学基金面上项目，81370660，课题负责人，70.0万）
2018.01-2021.12 下调p38MAPKα-Mitf-嘌呤与mTORC1-SREBP1-脂质合成轴阻止扩增人HSCs的衰老（国家自然科学基金面上项目，81770192，课题负责人，50.0万）
2020.01-2023.12 抑制RAB27B靶向重启急性髓系白血病干细胞衰老同时阻止其干性维持与机制的研究（国家自然科学基金面上项目，81973999，课题负责人，55.0万）

发表论文

Danyue Peng, Huifang Wang, Lei Li, Xiao Ma, Ying Chen, Hao Zhou1, Yi Luo, Yin Xiao, Lingbo Liu. miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. Leukemia 2018 May;32(5):1180-1188
Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood 2014 May 15;123(20):3105-3115
Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L. Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence. Transplantation 2014 Jan 15;97(1):20-29
Yin Xiao, Jie Wang, Hui Song, Ping Zou, Daohong Zhou，Lingbo Liu. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence. Leuk Res 2013 Mar;37(3):333-340
Jing Zou, Ping Zou, Jie Wang, Lei Li, Yong Wang, Daohong Zhou, Lingbo Liu. Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells. Ann Hematol 2012 Jun;91(6):813-823
Luo Y, Zou P, Zou J, Wang J, Zhou D, Liu L. Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner. Exp Gerontol 2011 Nov 23;46(11):860-867
Wang Y, Liu L, Pazhanisamy SK, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med 2010 Jan 15;48(2):348-356
Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury. Radiat Res 2011 Dec;176(6):743-752
Wang Y, Kellner J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev 2011 Jul;20(7):1143-1152

刘素梅

学习和工作经历
2017-现在教授，美国威斯康星大学拉克罗斯分校科学与健康学院生物学系
2013-2017 副教授，美国威斯康星大学拉克罗斯分校科学与健康学院生物学系
2009-2013 助理教授，美国威斯康星大学拉克罗斯分校科学与健康学院生物学系
2005-2009 助理教授，美国俄亥俄州立大学医学院内科系消化专科
2005-2009 助理教授，美国俄亥俄州立大学医学院生理及细胞生物学系
2002-2005 博士后，美国俄亥俄州立大学医学院生理及细胞生物学系
1996-2002 助理研究员（博士生），美国俄亥俄州立大学医学院生理及细胞生物学系
1993-1996 讲师，首都医科大学基础医学院生理学教研室
1996-2002 博士，美国俄亥俄州立大学医学院生理及细胞生物学专业
1990-1993 硕士，北京师范大学生物学系生理学专业
1986-1990 学士，北京师范大学生物学系生物学专业

学术及社会任职
2017-2019 美国生理学会教育委员会委员
2013 美国国家自然科学基金评审(Panelist for Processes Structure & Integrity-Animal 1)
Acta Pharmacologica Sinica, Acta Physiologica Sinica, American Journal of Physiology-GI, Autonomic Neuroscience-Basic and Clinical, BMC-Physiology, BMC-Research Notes, British Journal of Pharmacology, Digestive Disease and Science, European Journal of Pharmacology, Frontiers in Neuroscience, Gastroenterology, International Journal of Biomedical Science, Journal of Applied Physiology, Journal of Pharmacological Sciences, Journal of Physiology, Journal of Visualized Experiments, Neurogastroenterology and Motility, Neuroscience, Neuroscience letter, Physiological research, PLos One, Regulatory peptide, Translational Research

发表论文

Liu S. Neurotrophic factors in enteric physiology and pathophysiology. Neurogastroenterol Motil 2018 Oct;30(10):e13446
Liu S, Hagiwara SI, Bhargava A. Early-life adversity, epigenetics, and visceral hypersensitivity. Neurogastroenterol Motil 2017 Sep;29(9):e13170
Liu S, Chang J, Long N, Beckwith K, Talhouarne G, Brooks, JJ, Qu MH, Ren W, Wood JD, Cooper S, Bhargava A. Endogenous CRF in rat large intestine mediates motor and secretory responses to stress. Neurogastroenterol Motil 2016;28(2):281-291
Wang GD, Wang XY, Liu S, Xia Y, Zou F, Qu M, Needleman BJ, Mikami DJ, Wood JD. β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum. Am J Physiol Gastrointest Liver Physiol 2015;308(11):G955–G963
Wang GD, Wang XY, Liu S, Qu M, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol 2014;307(7):G719-G731
Wang GD, Wang XY, Zou F, Qu M, Liu S, Fei G, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Mast cell expression of the serotonin 1A receptor in guinea pig and human intestine. Am J Physiol Gastrointest Liver Physiol 2013 304(10):G855-G863
Fei G, Fang X, Wang GD, Liu S, Wang XY, Xia Y, Wood JD. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum. Br J Pharmacol 2013;168(4):880-890
Ji T, Liu S, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX. Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock. Cell and Tissue Research 2012;348(1):155-165
Xu JD#, Liu S#, Wang W, Li LS, Li XF, Li Y, Guo H, Hou XL, Zhang Y, Zhu JX. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br J Pharmacol 2012;165(1):197-207 (#Both authors contributed equally to this work)
Wood JD, Liu S, Drossman DA, Ringel Y, Whitehead WE. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. J Neurogastroenterol Motil 2012;18(1):78-85
Sun X, Wang X, Wang GD, Xia Y, Liu S, Qu M, Needleman BJ, Mikami DJ, Scott Melvin W, Bohn LM, Ueno R, Wood JD. Lubiprostone Reverses the Inhibitory Action of Morphine on Mucosal Secretion in Human Small Intestine. Dig Dis Sci 2011;56(2):330-338
Zhang XH, Ji T, Guo H, Liu SM, Li Y, Zheng LF, Zhang Y, Zhang XF, Duan ZP, Zhu JX. Expression and activation of β-adrenoceptors in the colorectal mucosa of rat and human. Neurogastroenterol Motil 2010;22(11):e325-e334
Fei G, Raehal K, Liu S, Qu M, Sun X, Wang GD, Wang XY, Xia Y, Schmid CL, Bohn LM, Wood JD. Lubiprostone (SPI-0211) reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther 2010;334(1):333-340
Yang N#, Liu SM#, Zheng LF, Ji T, Li Y, Mi XL, Xue H, Ren W, Xu JD, Zhang XH, Li LS, Zhang Y, Zhu JX. Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 2010;159(8):1623-1635. (#Both authors contributed equally to this work)
Liu S, Ren W, Qu MH, Bishop GA, Wang GD, Wang XY, Xia Y, Wood JD. Differential Actions of Urocortins on Neurons of the Myenteric Division of the Enteric Nervous System in Guinea Pig Distal Colon. British Journal of Pharmacology 2010;159(1):222-236

发表专著

Li S, Fei G, Liu S. Rome IV, The Functional Gastrointestinal Disorders (Chinese edition). China Science Press, 4th ed. Vol 1, pp 59. ISPN: 9787030502179. 2016
Liu S. Enteric Nervous System, in “Progress in Physiology”. Editors: Jianjun Wang and Xiaomin Wang. Higher Education Press, Beijing, China. ISBN: 9787040398359. 2014
Liu S, Wood JD. Neurobiology of stress, in “Physiology of the Gastrointestinal Tract”, 5th ed. Editors: Johnson, Barrett, Ghishan, Merchant, Said, and Wood. Academic Press, Maryland Heights, MO. ISPN: 9780123820266. 2012
Liu S, Wood JD. Neurobiology of corticotropin-releasing factor in the enteric nervous system during stress, in “Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment”. Frontiers in Gastrointestinal Research. Editors: Filaretova LP, Takeuchi K. Basel, Karger, vol 30, pp 115–123. ISBN: 9783318021837. 2012

孙金鹏

北京大学生理与病理学教授。山东大学基础医学院生物化学与分子生物学系主任，博士生导师；国家杰出青年基金获得者（药理学）。

1993-1998年，中国科学技术大学，获得生物学和计算机科学双学位；2001-2007年，美国爱因斯坦医学院分子药理学专业，获得博士学位；2007-2011年，在杜克大学Robert J Lefkowitz教授(2012年GPCR领域诺贝尔化学奖)实验室从事膜受体GPCR的相关研究。

孙金鹏长期从事膜受体G蛋白偶联受体（GPCR）的相关研究，在美国留学10年后回国建立了独立研究团队，以GPCR功能多样性的细胞机制为主要研究内容，立足国内，发展了Arrestin所介导的GPCR偏向性信号转导的药理学理论，阐明了GPCR偏向性在胰岛素分泌和糖代谢中的调控功能，并开发了系列偏向性干预策略。回国后，（１）创新性地提出了GPCR磷酸化编码的“笛子模型”（Nature Communications 2015, Faculty 1000专题评论, 引用59次），和多聚脯氨酸码头分选及别构建调控理论（Nature Chemical Biology 2018），并可应用新模式发展磷酸酶抑制剂，从而有效地操控受体的磷酸化编码的新理念（Cell Research 2014, Cell Reports 2016, 获2014年Cell Research的专题评论），为GPCR的偏向性药物开发奠定了理论基础；发现了GPCR下游Arrestin偏向性信号途径激活离子通道的一种非G蛋白依赖的全新快速机制，打破了人们对GPCR信号转导的固有认识（Nature Communications 2017 杂志专题评论, Nature Communications 2018）；（2）揭示了GPCR在顶膜区域信号转导对重吸收的调控作用（Elife 2018, Faculty 1000专题评论）；（3）阐明了GPCR下游G蛋白或Arrestin偏向性信号途径对胰岛功能及糖代谢的调控作用，为进一步靶向GPCR偏向性信号途径的药物设计提供了指导（Biol Psychiatry 2017 封面文章, Faculty 1000专题评论, Diabetologia 2014, Br J Pharmacol 2015）；（4）建立了靶向GPCR偏向性信号途径的Aptamer和小分子抑制剂的开发方法，获得了一系列GPCR的偏向性配体以及GPCR下游磷酸酶的特异性抑制剂（Future Med Chem 2015, J Med Chem 2014）。

在该领域，孙金鹏教授已在Nature Medicine, Nature Chemical Biology, Nature Communications, PNAS, Biol Psychiatry, Cell Research, Cell Reports, Diabetologia, J Med Chem, Br J Pharm, J Biol Chem, Biomaterials, FASEB J等SCI收录杂志发表60余篇文章，总影响因子505，文章总引用次数2000余次；第一作者文章6篇，影响因子合计35；特别是回国后近五年通讯作者文章34篇，影响因子合计206，引用次数总计400余次；其中6篇通讯作者文章影响因子大于10，4篇通讯文章被Faculty1000专门推荐，2篇通讯获得杂志的专题评述，2篇通讯文章被选为杂志封面。鉴于上述研究成果，申请人受邀在药理学相关杂志Mol Pharm, J Neuro Chem, Int J Biochem Cell Biol等撰写综述，并应邀在关于G蛋白偶联受体的药理学研究的双清论坛（2014），全国化学生物学大会（2015），全国受体专业委员会（2016，2017）；全国生物化学与分子生物学药理学会（2017），全国肾脏药理学会（2017），中美药理学会（2017），亚洲药学会（2017）和第17届嗜铬细胞国际大会（2017，英国）等会议进行专题报告；获得2015年山东省高等学校优秀科研成果奖一等奖。在2017年药理学的专业杂志Mol Pharm介绍中国近10年的药物靶点GPCR的工作时，开篇即系列介绍了孙金鹏教授在GPCR偏向性信号转导所做的一系列工作，产生了较好的国际影响。

发表论文 (#通讯作者；*第一作者及共同作者)

Gong Q*, Qin W*, Xiao P*, Wu X, Li L#, Zhang G, Zhang R, Sun J#, Yao SQ#, Huang W#. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb) 2019 Dec 17;56(1):58-61
Huang SM#, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP#, Wang J#. A Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem 2019 Dec 3;91(23):14936-14942
Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY#. Structural Mechanism of the Arrestin-3/JNK3 Interaction. Structure 2019 Jul 2;27(7):1162-1170
Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X#. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem 2019 May 24;294(21):8653-8663
Rostaminasab Dolatabad M, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Hong-da L, Shen YM, Yu X, Sun JP#*, Zhang PJ#. Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem 2019 Feb;148(4):550-560
Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors. J Chem Inf Model 2018 Nov 26;58(11):2331-2342
Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, Wu JW#, Sun J#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem 2018 Oct 19;293(42):16226-16241
Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nat Chem Biol 2018 Sep;14(9):876-886
Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis 2018 Jun 7;9(6):682
Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Targeting receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer. Nature Medicine 2018 May;24(4):505-551
Gpr97 Exacerbates AKI by Mediating Sema3A Signaling. Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun J, Li N, Yi F. J Am Soc Nephrol 2018 May;29(5):1475-1489
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife 2018 Feb 2;7:e33432
Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong Wei#. Direct Interaction and Dual Roles of Homocysteine on the Angiotensin II Type 1 Receptor in the Aggravation of Vascular Injury. Nat Commun 2018 Jan 2;9(1)
Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J 2018 Jan;32(1):73-82
Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F. β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice. J Mol Med (Berl) 2018 Jan;96(1):97-109
Xiao K, Sun J. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal 2018 Jan;41:56-64
Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem 2018;49(2):728-742
Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun J#, Sun H#.Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials 2017 Sep;140:220-229
Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol 2017 Sep;92(3):201-210
Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest 2017 Jun 30;127(7):2631-2646
Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Lin A, Kahsai A, Cahill III T, Chen ZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry 2017 Apr 15;81(8):654-670
Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A 2017 Mar 7;114(10):2562-2567
Liu CH, Gong Z, Liang Zl, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Xiao KH, Zhou Z, Yu X, Sun JP#. Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun 2017 Feb 9;8:14335
Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H, Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett 2016 Oct 1;26(19):4795-4798
Sun J#, Zhang D, Wang Y, Lin H, Yu X, Xu Z. The Role of G Protein-coupled Receptors in Cochlear Planar Cell Polarity. Int J Biochem Cell Biol 2016 Aug;77(Pt B):220-225
Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12. Cell Reports 2016 May 10;15(6):1345-358
J Liu, QX Li, XJ Wang, C Zhang, YQ Duan, ZY Wang, Y Zhang, X Yu, NJ Li, JP Sun#，F Yi#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death Dis 2016 Apr 7;7(4):e2183
Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X, Sun J#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. Future Med Chem 2015 Dec;7(18):2429-2437
Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP#. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem 2015 Dec;10(12):1980-1987
Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#, Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells. Br J Pharmacol 2015 Nov;172(21):5050-5067
Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nat Commun 2015 Sep 8;6:8202
Hou X, Li K, Yu X, Sun JP, Fang H. Protein Flexibility in Docking-based Virtual Screening: Discovery of Novel Lymphoid-specific Tyrosine Phosphatase Inhibitors using Multiple Crystal Structures. J Chem Inf Model 2015 Sep 28;55(9):1973-1983
Liu HD, Wang WB, Xu ZG, Liu CH, He DF, Du LP, Li MY, Yu X, Sun JP#. G protein-coupled receptor 120：A hot target for the development of anti-diabetic therapies. Eur J Pharmacol 2015 Sep 15;763(Pt B):160-168
Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep 2015 Feb 24;5:8560
Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP#. Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors. J Neurochem 2014 Dec;131(6):699-711
Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP#. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. Int J Biochem Cell Biol 2014 Dec;57:84-95
Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J Med Chem 2014 Nov 26;57(22):9309-9322
Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Res 2014 Sep;24(9):1067-1090
Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia 2014 Sep;57(9):1899-1910
Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem 2014 Aug 29;289(35):24215-24225
Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols 2014 Jun;9(6):1301-1319
Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen AR, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism At A G Protein-Coupled Receptor (GPCR). J Biol Chem 2014 May 16;289(20):14211-14224
Kotula JW*, Sun J* (Co-first author), Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth. PLoS One 2014 Apr 15;9(4):e93441
Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). J Neurochem 2014 Jan;128(2):315-329
Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#, Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Sci Rep 2013;3:2333
Wang K, Zhu D, Yu X, Sun J, Yao W. Differences in the H2S-induced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats. Toxicology 2013 Oct 4;312C:12-17
Jiang H, Sun J, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis 2013 Aug 8;4:e761
Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. PPM1A functions as an ERK phosphatase. FEBS J 2013 Jun;280(11):2700-2711
Sun JP#*, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci 2013 May;50(1):204-214
Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun J, Gong W, Tian C, Wang J. A Genetically Encoded (19) F NMR Probe for Tyrosine Phosphorylation. Angew Chem Int Ed Engl 2013 Apr 2;52(14):3958-3962
Zhu D, Yu X, Sun J, Li J, Ma X, Yao W.H(2)S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology 2012 Dec 8;302(1):40-43
Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci 2012 Oct;48(2):456-463
Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X. Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol 2012 Mar 1;302(5):C796-803
Xiao P, Yang L, Zhang C, Wang JY, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB 2012;39(11):1050-1060
Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q, Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE 2012;7(8):e43631
Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, Zhang ZY. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem 2011 Sep 2;286(35):30526-30534
Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor. Nature Chemical Biology 2011 Aug 21;7(10):692-700
Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci USA 2010 Aug;107(34):15299-15304
Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica 2010 Apr;25:163-170
李慧, 郑文帅, 龚正, 孙金鹏#. 从医生到杰出科学家: 山东大学学报医学版 2012 12;50(No.12):1-9
李慧, 孙金鹏#. 生命中的两次召唤: 山东大学学报医学版 2012 12;50(No.12):10-11
谢迪东, 龚正, 李容, 李慧, 刘宏达, 孙金鹏#, 庞琦#. 磷酸酶STEP的Q-loop中T541参与催化反应的机制. 山大学报 2013.8
杨笃晓, 孙金鹏#. 现代药靶的核心分子G蛋白偶联受体科学发展报告 2013;88-96
肖鹏, 孙金鹏, 裴钢. G蛋白偶联受体结构分析的近年进展新生物学年鉴

田中民

西安交通大学生命科学与技术学院教授，博士生导师
地址：西安咸宁西路28号，西安交通大学生命科学与技术学院，教二北楼 523
Phone: 029-82663286-92
Email: zmtian@mail.xjtu.edu.cn
个人主页：http://gr.xjtu.edu.cn/web/zmtian

学习和工作经历
1991年毕业于西北大学生物系；2000年，西北大学生物系获硕士学位；2004年西安交通大学生物医学工程系获博士学位；2006－2008美国威斯康星医学院，生理系博士后研究工作；2008年入选教育部“新世纪优秀人才”支持计划；2009年美国威斯康星医学院生理系访问学者。2010年西安交通大学生命科学与技术学院教授。

学术及社会任职
中国生理学会肾脏专业委员会委员；中国生物医学工程委员会第三届超声生物效应专业委员会常务委员和副主任委员
Analytica Chimica Acta，Physiol Genomics，Current Pharmaceutical Design, Current Drug Delivery, Analytical Methods, scientific report, Journal of Diabetes Research, BMC Cardiovascular Disorders, Life Sciences, Pharmaceutics

发表论文

Xuewei Zheng, Meng Chen, Xiaoxue Li, Pengfei Yang, Xinrui Zhao, Yanan Ouyang, Zhe Yang, Mingyu Liang, Entai Hou*, Zhongmin Tian*. Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats. Hypertens Res. 2019 Nov;42(11):1672-1682
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang, Zhongmin Tian*. The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food & Function. 2019;10(2):849-858
Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu, Yong Liu, Purushottam W Laud, Kristie Usa, Yongcheng He, Mingyu Liang. Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018;8(6):1468-1480
Hou E, Li X, Liu Z, Zhang F, Tian Z. Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism. Biomed Chromatogr. 2018 Apr;32(4):e4133
Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z*, Liang M*. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 1;49(9):496-504
Zhengjun Wang, Qiong Sun, Na Sun, Mingyu Liang, Zhongmin Tian*. Mitochondrial dysfunction and altered renal metabolism in Dahl salt-sensitive rats. Kidney Blood Press Res. 2017;42(3):587-597
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian*. Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Rep. 2017 May 23;19(8):1631-1639
Le Wang, Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian*. Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men. Anal Chim Acta. 2015 Jan 7;854:95-105
Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, Zhongmin Tian*. Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression. Biochimie. 2015 Feb;109:27-35
Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian*. Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochem Biophys Res Commun. 2014 Jul 18;450(1):863-869
Xiaofeng He, Yong Liu, Kristie Usa, Zhongmin Tian, Allen W Cowley Jr, Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014 May 15;306(10):F1190-F1197
Alison J Kriegel, Yi Fang, Yong Liu, Zhongmin Tian, Domagoj Mladinov, Isaac R Matus, Xiaoqiang Ding, Andrew S Greene, Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382. Nucleic Acids Res. 2010 Dec;38(22):8338-8347

王海滨

厦门大学特聘教授，“生殖调控与生殖健康研究”福建省高校重点实验室主任；国家杰出青年基金获得者、科技部中青年科技创新领军人才入选者，973项目首席科学家、国家重点研发计划项目负责人。
地址：厦门市翔安区翔安南路厦门大学医学院成义楼219
邮编: 361102
电话: +86‐592‐2880501
邮箱: haibin.wang@vip.163.com

学习和工作经历
2016-至今：厦门大学医学院，生殖调控与生殖健康福建省高校重点实验室主任
2008‐2016：中国科学院动物研究所，干细胞与生殖生物学国家重点实验室研究员
2006‐2008：美国范德堡大学医学中心，儿科系助理教授
2004‐2006：美国范德堡大学医学中心，儿科系研究助理教授
2002‐2004：美国范德堡大学医学中心(Vanderbilt University Medical Center) 儿科系博士后，合作导师: SK Dey教授
2001‐2002：美国堪萨斯大学医学中心(University of Kansas Medical Center) 整合生理学系博士后，合作导师: SK Dey教授

奖励和荣誉
科技部中青年科技创新领军人才入选者
中国青年科技奖（2013年）
入选福建省高校领军人才和厦门市“双百计划”海外高层次人才
全国妇幼健康科学技术奖自然科学奖一等奖
厦门市青年英才首批杰出青年奖
中国科学院青年科学家奖（2011年）
中国科学院朱李月华优秀教师奖（2013年）
国家杰出青年基金获得者（2008年）

学术及社会任职
美国生殖生物学会（SSR）会刊Biol Reprod副主编
Am J Reprod Immunol编委
J Reprod Immunol编委
PLoS ONE编委
Scientific Reports编委
Development & Reproduction编委
Reproductive Medicine and Biology编委
Animal Models and Experimental Medicine编委
中华生殖与避孕杂志（英文刊）编委
科技导报编委
母胎医学杂志（英文刊）编委
生理学报编委
中国生理学会常务理事和生殖科学专业委员会主委

发表论文

He B, Zhang H, Wang J, Liu M, Sun Y, C Guo, Lu J, Wang H*, Kong S*. Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation. Proc Natl Acad Sci U S A. 2019;116(33):16621-16630
Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018 Jan 2;128(1):175-189
Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 Dec;24(12):2013-2021
Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114(18):4816-4821
Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016;23(1):169-181
Liao Y, Jiang Y, He H, Ni H, Tu Z, Zhang S, Wang B, Lou J, Quan S*, Wang H*. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Hum Reprod. 2015;30(7):1665-1676
Tang X, Chen Y, Ran H, Jiang Y, He B, Wang B, Kong S*, Wang H*. Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice. Biol Reprod. 2015 May;92(5):118
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res. 2014;24(8):925-942
Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*, Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 2014;90(3):52
Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013;11(4):e1001536

王韵

北京大学教授，国家杰出青年基金获得者，北京大学医学部基础医学院副院长，北京大学神经科学研究所副所长，中国生理学会理事长，教育部基础医学教学指导委员会副主任委员。

1996年获北京医科大学（现北京大学医学部）医学博士学位；2000-2002美国国立健康研究院访问学者；1992-1993年北京医科大学生理学系助教；1993-2004年北京大学神经科学研究所，神经生物学系讲师、副教授，2004-至今，北京大学神经科学研究所，神经生物学系教授。2013年至今，北京大学麦戈文脑科学研究所PI。曾获张香桐神经科学青年科学家奖及中国女医师协会五洲女子科技奖。教育部高校优秀青年教师及奖励基金、全国优秀科学科技工作者，北京大学十佳教师、北京市“教育先锋”先进个人和北京市高等教育教学名师等荣誉称号，国务院政府特殊津贴专家。

长期致力于痛及痛觉调制信号通路研究，近年来开展了神经系统发育，损伤及修复及其与痛觉产生相互关系等研究领域。作为课题负责人先后获得了国家自然科学重点，杰出青年，国际重大合作项目，面上基金及科技部“973”项目等20余项基金资助。共发表SCI论文近61篇，系列文章刊登在Nature Communication, Cell Reports, The Journal of Neuroscience和Science Signaling等期刊，获中国发明专利6项。

发表论文

Liu J*, Du J*, Wang YCA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal. 2019 Jun 11;12(585):eaaw2040
Hu F*, Liu HC*, Su DQ*, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB J. 2019 Jan;33(1):668-682
Tian NX*, Xu Y*, Yang JY, Li L, Sun XH, Wang YCA, Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci. 2018 Feb 14;38(7):1756-1773
Cen C*, Luo LD*, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Yimin Zou, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci. 2018 Jan 3;38(1):183-199
Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017 Sep;295:66-76
Qin R*, Cao S*, Lyu T, Qi C, Zhang W, Wang YCA. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390
Zhang C*, Lu J*, Liu B, Cui Q, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016 Feb;8(2):272-290
Liu J*, Du J*, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015 Nov;273:253-262
Wang GQ*, Cen C*, Cao S*, Li C*, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA, Wang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015 Jul 16;6:7660
Li Y*, Hu F*, Chen HJ*, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61
Wang N*, Su P*, Zhang Y*, Lu J*, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014 Apr;39(5):1290-1301
Qi C*, Liu SM*, Qin R*, Zhang Y, Wang GQ, Shang, YF, Wang YCA, Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 Mar 26;34(13):4494-508

徐广银

江苏特聘教授、江苏省高层次创新创业引进人才、江苏省双创团队领军人才、苏州大学医学部常务副主任、苏州大学神经科学研究所副所长、苏州大学疼痛转化医学中心主任。长期从事慢性痛特别是功能性内脏痛的神经分子机制研究，先后在美国德州大学盖尔维斯顿医学部内科系任Instructor以及Assistant Professor (Tenure-Track)。在美工作期间，建立了独立的慢性痛研究室，曾以PI和 Co-PI的身份获包括NIH在内的多项科研基金资助。主要研究成果已发表在国际权威期刊PNAS, Journal of Neuroscience, Gastroenterology, GUT等。在博士后工作期间率先在国际上开展了蛋白激酶CaMKⅡ调节P2XR胞膜转运介导慢性痛的外周神经细胞机制的研究。2008年首创发现P2X3受体参与肠激综合症功能性内脏痛产生和发展，研究成果发表在国际著名权威期刊GUT, P2X受体发现者Burnstock博士为这个发现撰写评论。自2000年来在国际著名权威 SCI学术刊物上发表论文80余篇。现任中国神经科学会副理事长，中国神经学会神经内稳态和内分泌分会主任委员；中国生理学会人体微生态专业委员会主任委员；（首创）中国生理学会消化与营养专业委员会前任主任委员，（首创）江苏省双创人才分会常务理事，江苏省医学会疼痛学分会副主任委员，江苏省神经科学学会副理事长，江苏省生理科学学会理事，上海脑科学与类脑研究中心专家组专家，徐州市人民政府科技顾问，江苏省医学科技奖评审委员会顾问，苏州大学校学术委员会副主任委员。担任第七届和第八届海内外华人神经科学家研讨会副主席和主席、第六届亚洲疼痛研讨会主席(2015)、中国神经科学学会神经内稳态和内分泌分会主席（2016-2019）、中国生理学会消化与营养专业委员会学术会议主席(2016-2017)、并成功组织2014年国际脑组织苏州学习班；任Neuroscience Bulletin常务副主编, Molecular Pain副主编，Biomed Research International, American Journal of Psychiatry and Neuroscience, Pain and Itch, 《生理学报》及《中国疼痛医学杂志》编委; 担任GUT, Molecular Pain, Neuropeptides, Am J Physiol等二十多本国际权威SCI期刊的同行评审专家。国家自然科学基金委同行评审专家和终审专家，国家自然科学基金重大项目专家组成员等。获国家自然科学基金委重点（2项）、重点国际合作项目和面上项目资助。

发表论文

Zhang Y, Song J, He XZ, Xiong J, Xue R, Ge JH, Lu SY, Hu D, Zhang GX, Xu GY*, Wang LH*. Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry. Neurosci Bull. 2020 Jul 25
Zhang PA, Sun Q, Li YC, Weng RX, Wu R, Zhang HH, Xu GY*. Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes. Neurosci Bull. 2020 Jul;36(7):719-732
Li X, Xu YC, Tian YQ, Zhang PA, Hu SF, Wang LH, Jiang XH*, Xu GY*. Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation. Mol Pain. 2020 Jan-Dec;16:1744806920930858
Weng RX, Chen W, Tang JN, Sun Q, Li M, Xu X, Zhang PA, Zhang Y, Hu CY*, Xu GY*. Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation. Mol Pain. 2020 Jan-Dec;16:1744806920918059
Long HC, Wu R, Liu CF, Xiong FL, Xu Z, He D, Zhang YF, Shao B, Zhang PA, Xu GY*, Chu L*. MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis. Neurosci Bull. 2020 Feb;36(2):110-120
Zhang C, Lin J, Wei F, Song J, Chen W, Shan L, Xue R, Wang G, Tao J, Zhang G, Xu GY*, Wang L*. Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine. Life Sci. 2018 May 15;201:150-160
Hong-Hong Zhang, Ji Hu*, You-Lang Zhou, Xin Qin, Zhen-Yuan Song, Pan-Pan Yang, Shu-Fen Hu, Xing-Hong Jiang, Guang-Yin Xu*. Promoted interaction of nuclear factor-kappa B with demethylated purinergic P2X3 receptor gene contributes to neuropathic pain in rats with diabetes. Diabetes. 2015 Dec;64(12):4272-4284
Hong-Hong Zhang, Ji Hu, You-Lang Zhou, Shu-Fen Hu, Yong-Meng Wang, Wei Chen, Ying Xiao, Li-Yen Mae Huang, Xing-Hong Jiang, Guang-Yin Xu*. Promoted interaction of nuclear factor-kappa B with demethylated cystathionine-beta-synthetase gene contributes to gastric hypersensitivity in diabetic rats. Journal of Neuroscience. 2013 May 22;33(21):9028-9038

杨斌

英国谢菲尔德大学医学博士，英国莱斯特大学荣誉教授(Honorary Professor in Renal Medicine)，系中国事务部主任；2016年入选南通大学附属医院江苏特聘医学专家，任南通大学附属医院肾脏病研究所所长、肾内科副主任；2018年创建任南通-莱斯特联合肾脏病学研究所，任所长；历任南通大学特聘教授及复旦大学中山医院客座教授，博士生导师。

近年获得英-中杰出研究员基金、3项国自然面上项目以及江苏特聘医学专家基金等的资助，主持了多项课题研究，在基础医学及其临床转化研究方面利用多种肾损伤的生物学模型，如近端肾小管上皮细胞和巨噬细胞培养, 离体肾再灌注, 大、小鼠肾缺血再灌注损伤和猪自体肾移植等作了一系列相关研究，特别是与细胞凋亡、炎症、免疫及纤维化相关的基因 siRNA干预，以及重组人促红素及其衍生物对急、慢性肾脏损伤保护作用等的多层面研究；并从人移植肾活检标本基因表达谱的研究，以及与临床资料进行相关分析中获得了系统研究分析基因组学高通量生物信息资料的经验，有助于推进和拓展精准医学的研究及临床应用。

以第一作者或通讯作者在国际有影响力的杂志如J Clin Invest (1997), J Am Soc Nephrol (2001x2及2008), Kidney Int（2001, 2002, 2003及2005), Mol Ther (2014), Transplantation (2006, 2010, 2011)及J Transl Med (2013, 2014, 2015)和Sci Rep (2018)等发表多篇研究文章，累计影响因子200余分，被应用700余次。多次应邀在英国、欧洲、国际和美国肾脏病及移植等会议发言，为英国医学科研基金会(Medical Research Council)及国自然面上项目及青年基金审稿人；欧洲移植学会会员、英国移植学会会员、英国肾脏病学会等专业学会会员。为20多种SCI杂志如Kidney Int, J Am Soc Nephrol, Mol Ther和Am J Transplant等特邀审稿人。

参与多层次国际合作交流及年轻人的培养，促成南通大学、复旦大学和莱斯特大学间多层次的互访，建立了稳定的合作交流渠道，包括联合培养博士研究生划和年轻教师短期英语及学术培训等。促成南通大学附属医院肾内科与莱斯特大学肾脏病中心结为国际肾脏病协会资助的姐妹肾脏病中心，创建南通-莱斯特联合肾脏病学研究所，以改善肾脏疾病早期诊断和管理，促进肾损伤修复，减少急性肾损伤的死亡率及慢性肾损伤的发生率，更好地服务于当地及全球肾脏病人。

邮箱: by5@le.ac.uk或dryangbin@hotmail.com
电话: 0044 116 2231046, 手机：0044 7466836765或0086 15962977362

发表论文

Yang C, Qi R, Yang B*. Pathogenesis of Chronic Allograft Dysfunction Progress to Renal Fibrosis. Adv Exp Med Biol 2019;1165:101-116
Liu A, Yang B*. Role of TRPM7 in Renal Ischemia-Reperfusion Injury. Curr Protein Pept Sci 2019;20:777
Aifen Liu, Jing Wu, Cheng Yang, Yuanyuan Wu, Yufang Zhang, Fengbo Zhao, Hui Wang, Li Yuan, Lirui Song, Tongyu Zhu, Yaping Fan, Bin Yang*. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury. Sci Rep 2018 Apr 3;8(1):5510
Zwaini Z, Dai H, Stover C, Yang B*. Role of Complement Properdin in Renal Ischemia-Reperfusion Injury. Curr Gene Ther 2017;17(6):411-423
Hou-Yong Dai, Li-Na Ma, Yun Cao, Xiao-Lan Chen, Hui Shi, Ya-Ping Fan, Bin Yang*. Protection of CTGF Antibody Against Diabetic Nephropathy in Mice Via Reducing Glomerular β-Catenin Expression and Podocyte Epithelial-Mesenchymal Transition. J Cell Biochem 2017 Nov;118(11):3706-3712
Tang Q, Yang B, Fan F, Li P, Yang L, Guo Y. Effects of individualized exercise program on physical function, psychological dimensions, and health-related quality of life in patients with chronic kidney disease: A randomized controlled trial in China. Int J Nurs Pract 2017;23
Zhang Y, Chen W, Wu Y, Yang B*. Renoprotection and Mechanisms of Erythropoietin and Its Derivatives Helix B Surface Peptide in Kidney Injuries. Curr Protein Pept Sci 2017;18(12):1183
Yang C, Yang B*. Acute kidney injury in China: A neglected truth and perspective. Asian J Urol 2016 Jan;3(1):4-5
Yang C, Zhang C, Zhao Z, Zhu T, Yang B*. Fighting against kidney diseases with small interfering RNA: opportunities and challenges. J Transl Med 2015 Feb 1;13:39
Cheng Yang, Tian Zhao, Zitong Zhao, Yichen Jia, Long Li, Yufang Zhang, Mangen Song, Ruiming Rong, Ming Xu, Michael L Nicholson, Tongyu Zhu, Bin Yang*. Serum-stabilized naked caspase-3 siRNA protects autotransplant kidneys in a porcine model. Mol Ther 2014 Oct;22(10):1817-1828
Zitong Zhao, Cheng Yang, Long Li, Tian Zhao, Lingyan Wang, Ruiming Rong, Bin Yang*, Ming Xu, Tongyu Zhu. Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model. J Transl Med 2014 Feb 23;12:53
Yuanyuan Wu, Junlin Zhang, Feng Liu, Cheng Yang, Yufang Zhang, Aifen Liu, Lan Shi, Yajun Wu, Tongyu Zhu, Michael L Nicholson, Yaping Fan, Bin Yang*. Protective effects of HBSP on ischemia reperfusion and cyclosporine a induced renal injury. Clin Dev Immunol 2013;2013:758159
Cheng Yang, Long Li, Yinjia Xue, Zitong Zhao, Tian Zhao, Yichen Jia, Ruiming Rong, Ming Xu, Michael L Nicholson, Tongyu Zhu, Bin Yang*. Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA. J Transl Med 2013 Sep 13;11:210
Shuai Jiang, Qunye Tang, Ruiming Rong, Liangfeng Tang, Ming Xu, Jidong Lu, Yichen Jia, Yitreen Ooi, Jun Hou, Jianming Guo, Bin Yang*, Tongyu Zhu. Mycophenolate mofetil inhibits macrophage infiltration and kidney fibrosis in long-term ischemia-reperfusion injury. Eur J Pharmacol 2012 Aug 5;688(1-3):56-61
Bin Yang*, Sarah A Hosgood, Michael L Nicholson. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys. Transplantation 2011 Mar 15;91(5):501-507

杨黄恬

医学博士，研究员，博士生导师、中国科学院特聘研究员，分子心脏学研究组组长，中国科学院肿瘤与微环境重点实验室，中国科学院上海营养与健康研究所
地址: 上海市岳阳路320号生命实验大楼A栋1232室
电话：021-54923280
Email: htyang@sibs.ac.cn

学习和工作经历
2017-至今：中国科学院上海营养与健康研究院研究员
2000-2016：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所研究员
2005-2014：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所副所长
2003-2004：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所所长助理
1997-2001：美国国立卫生研究院/老年研究所(NIH/NIA)心血管研究室/分子心脏学室 Research fellow
1992-1997：日本山形大学医学部药理教研室客座研究员、助手
1992-1994：日本山形大学医学部医学博士
1988-1992：南通医学院药理教研室助教、讲师
1985-1988年：苏州医学院医学硕士
1982-1985：南通医学院药理教研室助教
1978-1982：南通医学院医学系医学学士

奖励和荣誉
科技部中青年科技创新领军人才入选者
中国青年科技奖（2013年）
入选福建省高校领军人才和厦门市“双百计划”海外高层次人才
全国妇幼健康科学技术奖自然科学奖一等奖
厦门市青年英才首批杰出青年奖
中国科学院青年科学家奖（2011年）
中国科学院朱李月华优秀教师奖（2013年）
国家杰出青年基金获得者（2008年）

学术及社会任职
国际心脏研究学会（ISHR）中国分会执委会副主席
国际心脏研究会中国转化医学工作委员会常务委员
中国病理生理学会心血管专业委员会委员
中国病理生理学会受体与信号转导专业委员会委员
中华医学会心脏再生专业委员会委员
中国药理学会心血管药理专业委员会常务委员
中华医学会心血管病学会员
中华医学会心血管病学分会基础研究学组第十届、第十一届委员会委员
上海细胞生物学学会副理事长
美国心脏学会 Professional会员
中国整形美容协会干细胞研究与应用分会常务理事
国际心脏研究学会 Fellow
AJP-Heart and Circulatory Physiology 编委
Cardiovascular Drugs and Therapy 编委
Acta Pharmacol Sinica 编委
Acta Physiologica Sinica 常务编委
Cell Death & Diseases 编委
Current Opinion in Physiology 编委
Engineering-Tissue Engineering 编委
Frontier in Pharmacology 编委
J Mol Cell Cardiol 副主编
Pflügers Archiv - European Journal of Physiology 副主编
中国应用生理学杂志编委
中国分子心脏病学杂志编委

发表论文

Liu YP^#, Bai HJ^#, Yang CL, Luo XL, Zhang P, Guo FF, Fen XQ, Phung T, Zhu D, Guo J, Liang P, Xu Z, Yang HT*, Lu XY*. PGC-1α Activator ZLN005 Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells. Aging. 2020 Apr 28;12(8):7411-7430
Wu Q^#, Wang JX^#, Tan WLW, Jiang Y, Wang SH, Li Q, Yu XJ, Tan JL, Liu SY, Zhang P, Tiang Z, Chen ZY, Foo RSY, Yang HT*. Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death & Disease. 2020 May 11;11(5):354
Hu JL^#, Liang H^#, Zhang H^#, Yang MZ^#, Sun W, Zhang P, Luo L, Feng JX, Bai HJ, Liu F, Zhang TP, Yang JY, Gao QS, Long YK, Ma XY, Chen Y, Zhong Q, Yu B, Liao S, Wang YB, Zhao Y, Zeng MS, Cao N, Wang JC, Chen W*, Yang HT*, Gao S*. FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Research. 2020 Mar 18;48(5):2733-2748
Poon E*, Luo XL, Webb S, Yan B, Zhao R, Wu S, Yang Y, Zhang P, Bai HJ, Shao JF, Chan C, Chan G, Tsang S, Gundry R, Yang HT, Boheler K*. The Cell Surface Marker CD36 Selectively identifies Matured, Mitochondria-rich hPSC-Cardiomyocytes. Cell Res. 2020 Mar 10. doi: 10.1038/s41422-020-0292-y
Bai H J, Zhang P, Ma L, Liang H, Wei G, Yang HT*. SMYD2 drives mesendodermal differentiation of human embryonic stem cells through mediating the transcriptional activation of key mesendodermal genes. Stem Cells. 2019 Nov;37(11):1401-1415
Wang X, Wang L, Wu Q, Bao F, Yang HT*, Qiu X*, Chang J*. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure. ACS applied materials & interfaces. 2019;11(1):1449-1468
Wang JX, Liu ML, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin Y, Paul C, Wang Y, Yang HT*. Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6. Antioxid Redox Signal. 2019 Aug 10;31(5):369-386
Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT*. Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A. Acta Pharmacol Sin. 2019 Sep;40(9):1168-1183
Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680
Tan JL, Shanshan Gu, Yanjun Zheng, Yang HT. Expression Profile of Circular RNAs in Myocardial Ischemia/Reperfusion with and without Intermittent Hypobaric Hypoxia Preconditioning. Sci China Life Sci. 2019 Aug;62(8):1104-1106
Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates. Circ Res. 2018 Mar 30;122(7):958-969
Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT*. IP3R-mediated Ca²⁺ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol. 2017 Aug 1;9(4):274-288. (cover article)
Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT*. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int. 2017;2017:1769298
Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017 Feb 2;8(2):e2577
Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A. 2017 Apr;105(4):1094-1104
Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016;22(10):1131-1139
Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP₃ receptors mediates differential Ca²⁺ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-478
Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells. 2016 Jun;34(6):1527-1540
Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca²⁺ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015 Apr;81:150-161
Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res. 2015 Feb 1;105(2):192-202
Ling Gao, Yanjun Zheng, Shanshan Gu, Jiliang Tan, Christian Paul, Yigang Wang, Huangtian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014 Dec;77:102-112
Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis. 2014 Jun 19;5:e1297
Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul;35(7):899-906
Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1569-H1581
Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 2013 Sep;23(9):1119-1132
Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca²⁺ Homeostasis and Preventing Calpain Activation. Circ J. 2012;76(8):1993-2002
Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol. 2012 Oct;97(10):1105-1118
Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang HT*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-1537
Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 2012 Jan;22(1):219-236
Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1695-H1705
Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca²⁺-independent Mechanism. J Cardiovasc Pharmacol. 2011 Jul;58(1):40-48
Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res. 2011 Sep;21(9):1316-1331
Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 May;106(3):329-342
Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT*. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010 Jul;17(7):1141-1154

评述与综述

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161-169
Wu Q, Yang HT*. Roles of Exosomes Secreted from Stem Cells and Their Derived Cells in Cardiac Repair Following Myocardial Infarction. Chinese Journal of Cell Biology. 中文版本. 2018;40(13):2198-2208
Xinyang Hu, HuangTian Yang, Yuangui Zhu, Jian'an Wang, Erdan Dong. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016;118(12):1876-1879 (viewpoint)
Yang HT*, Zhang M, Huang JJ, Liang H, Zhang P, Boheler KR. Cardiomyocytes derived from pluripotent stem cells: progress and prospects from China. Exp Cell Res. 2013;319(2):120-125
Feng Y, Wang Y, Cao N, Yang H, Wang Y*. Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med. 2012;1(1):65-77
Yang HT*. Adaptation to Intermittent Hypoxia Protects the Heart from Ischemia/Reperfusion Injury and Myocardial Infarction. Science. 2012.P47-48

发表专著

杨黄恬, 黄吉均, 郑严俊. 《疾病机制》(第1版)人民卫生出版社. 主编: 王建枝吴立玲陈琪; 第19章, 细胞治疗; ISBN 978-7-117-27283-4;323-330;2019.01
张敏, 高崚, 王志华, 杨黄恬*. 总论《中华医学百科全书—基础医学人体生理学》(Medical Encyclopedia of China). 主编唐朝枢. 中国协和医科大学出版社, 2017.7 ISBN 978-7-5679-0668-6
Nan Cao, He Liang, Huangtian Yang*. Generation, Expansion, and Differentiation of Cardiovascular Progenitor Cells from Human Pluripotent Stem Cells. Edited by Kursad Turksen, Ph.D., Cell-Cell Communications in Stem Cell Renewal: Methods Mol Biol. published by Springer 2015;1212:113-125
Yang HT*, Yi Zhang, Wang ZH and Zhou ZN. Chapter 4. Protective effects of chronic intermittent hypoxia against myocardial ischemia/reperfusion injury, p47-58 in the book Intermittent hypoxia and human diseases, Edited by Dr. Lei Xi and Dr. Tatiana V. Serebrovskaya, published by Springer (http://www.springerlink.com/content/978-1-4471-2905-9/?MUD=MP) in 2012
杨黄恬*, 王志华, 陈乐, 周兆年. 第45章低氧对心血管功能的影响及机制. P416-424《心血管生理学基础与临床》(研究生教学用书). 朱妙章, 唐朝枢, 袁文俊, 吴博威, 臧伟进, 朱大年主编-2版, 高等教育出版社出版, 2011.1
张海峰, 高崚, 王志华, 杨黄恬*, 高峰*. 第九节心脏细胞收缩/舒张功能及胞内钙离子浓度的测定, P61-69. 《心血管肾脏生理学实验技术方法及其进展》, 朱妙章主编, 第四军医大学出版社 2010.1
高崚, 王志华, 杨黄恬*. 第十节心肌细胞模拟缺血/再灌注模型和同步收缩与钙信号的记录分析, P70-73. 《心血管肾脏生理学实验技术方法及其进展》, 朱妙章主编, 第四军医大学出版社
Huangtian Yang*, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. P416-424. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2010

殷东敏

教授，研究组长，脑功能基因组学教育部重点实验室，华东师范大学生命科学院
地址：上海市中山北路3663号，华东师范大学脑功能基因组学研究所106室
电话：021-62238357
邮箱：dmyin@brain.ecnu.edu.cn

学习和工作经历
2014.07-至今研究员，博士生导师，华东师范大学，教育部脑功能基因组学重点实验室，基因与脑疾病研究方向学术带头人
2013.10-2014.07 助理研究员 (Assistant Research Scientist)，Department of Neuroscience and Regenerative Medicine, Georgia Regents University
2008.08-2013.10 博士后 (Postdoctoral Fellow)，Institute of molecular medicine and genetics, Georgia Regents University
2003.09-2008.07 理学博士，北京大学神经科学研究所
1998.09-2003.07 医学学士，南京医科大学临床医学系

奖励和荣誉
2009年张香桐神经科学研究生论文优秀奖（国家级）
2010年北京大学优秀博士学位论文三等奖
2012年美国脑研究联盟青年学者研究奖（国家级）
2015年度上海市青年科技启明星（A类）
2015年度上海高校特聘教授（东方学者）

学术及社会任职
上海市神经科学会理事
中国神经科学会会员
美国神经科学会会员
2010-现在 Molecular Brain, Plos One审稿人
2013-现在 Aging Research Reviews, hippocampus, Molecular Psychiatry审稿人
2015-现在 Nature Communication, Scientific Reports审稿人

学术会议墙报和口头报告

D Yin, JC Bean, WC Xiong, L Mei. PIN1 enhances the stability of ErbB4. 2009年美国神经科学年会, Chicago (墙报)
J Bean, D Yin, WC Xiong, L Mei. PIN1 regulates spine formation. 2009年美国神经科学年会, Chicago (墙报)
D Yin, YJ Chen, YS Lu, A Sathyamurthy, J Bean, C Smith, C Shen, X Liu, WC Xiong, L Mei. Reversal of schizophrenia-relevant behavioral deficits in neuregulin 1 transgenic mice. 2012年美国神经科学年会, Washington DC (口头报告)
D Yin, J Bean, L Thiri, A Sathyamurthy, WC Xiong, YJ. Chen, L Mei. Regulation of spine formation by ErbB4 in PV-positive interneurons. 2013年美日突触可塑性会议, University of Washington, Seattle (墙报)
D Yin, J Bean, L Thiri, A Sathyamurthy, WC Xiong, YJ Chen, L Mei. Regulation of spine formation by ErbB4 in PV-positive interneurons. 2013年美国神经科学年会, San Diego (墙报)
D Yin. Role of Neuregulin 1 in synapse formation and transmission and its implication in schizophrenia relevant endophenotype. 2014年海内外华人神经科学家大会, 苏州 (大会报告)

发表论文

Zhang HL, Long JW, Han W, Wang J, Song W, Lin GN, Yin DM*. Comparative analysis of cellular expression pattern of schizophrenia risk genes in human versus mouse cortex. Cell Biosci. 2019 Nov 4;9:89
Yu Q, Liu YZ, Zhu YB, Wang YY, Li Q, Yin DM*. Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain. Brain Struct Funct. 2019 Apr;224(3):1035-1049
Tan Z, Robinson HL, Yin DM, Liu Y, Liu F, Wang H, Lin TW, Xing G, Gan L, Xiong WC, Mei L*. Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 2018 Apr 18;98(2):380-393
Zhu YB#, GW#, Zhang Y#, Feng J, Zhang HL, Liu YZ, Sun XF, Yin Y, Yin DM*. Astrocyte-derived phosphatidic acid promotes dendritic branching. Sci Rep 2016 Feb 17;6:21096
Yin DM#, Chen YJ#, Liu S, Jiao H, Shen C, Sathyamurthy A, Lin TW, Xiong WC, Li BM, Mei L*, Bergson C*. Calcyon Stimulates Neuregulin 1 Maturation and Signaling. Mol Psychiatry 2015 Oct;20(10):1251-1260
Sathyamurthy A, Yin DM, Barik A, Shen C, Bean JC, Figueiredo D, She JX, Xiong WC, Mei L*. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development 2015;142:522-532
Lu Y#, Sun XD#, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM*, Mei L*. Maintenance of GABAergic activity by neuregulin1-ErbB4 in amygdala for fear memory. Neuron 2014;84:835-846
Bean JC, Lin TW, Sathyamurthy A, Yin DM, Xiong WC, Mei L*. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain. J Neurosci 2014;34:13549-13566
Yin DM, Sun XD, Bean JC, Lin TW, Sathyamurthy A, Xiong WC, Gao TM, Chen YJ*, Mei L*. Regulation of spine formation by ErbB4 in PV-positive interneurons. J Neurosci 2013;33:19295-19303
Yin DM, Xiong WC, Mei L*. Adolescent dopamine slows spine maturation. Nat Neurosci 2013;16:1514-1516
Yin DM#, Chen YJ#, Lu YS, Bean JC, Sathyamurthy A, Shen C, Liu X, Lin TW, Smith AC, Xiong WC, Mei L*. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron 2013;78:644-657 (high-lighted in Preview by O. Marin and B. Rico, Neuron 2013;78:577-579)
Zhu YB#, Kang K#, Zhang Y, Qi C, Li G, Yin DM*, Wang Y*. PLD1 negatively regulates dendritic branching. J Neurosci 2012;32:7960-7969 (high-lighted by “F1000”)
Tan GH#, Liu YY#, Hu XL, Yin DM, Mei L*, Xiong ZQ*. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci 2012;15:258-266 (high-lighted in News & Views by K. Narasimhan, Nat Neurosci 2012;15:179)
Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L*. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci 2011;31:8491-8501
Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L*. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci 2011;31:15-25
Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L*, Gao TM*. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A 2010;107:21818-21823
Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li J, Zhou Z, Wang KW, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci 2010;30:7575-7586
Wen L#, Lu YS#, Zhu XH#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L*. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A 2010;107:1211-1216

张发明

医学博士、主任医师、教授、博士生（博士后）导师。现任南京医科大学第二附属医院肠病中心主任、南京医科大学附属逸夫医院微生态治疗科主任。曾受国家留学基金委等公派两次到美国约翰霍普金斯医院学习。致力于菌群移植体系和整合微生态技术研究，发明系列设备、器械和技术：世界首台智能化粪菌分离系统用于洗涤菌群移植、经内镜肠道植管术（TET）实现全结肠途径重复菌群移植和给药、透明帽辅助内镜下硬化术（CAES）无痛治疗痔疮和粘膜脱垂等。发起中华粪菌库-紧急救援计划（www.fmtbank.org），用于全国感染患者的救援治疗。建立中国菌群移植平台实时开放菌群移植安全性评价结果。江苏省十三五科教强卫工程领军人才，主持国家自然科学基金、江苏省重大科技专项等各类项目14项。中国肠道大会共同创始发起人兼执行主席。中国抗癌协会肿瘤与微生态专业委员会副主任委员。擅长消化内镜微创诊疗技术及溃疡性结肠炎、克罗恩病、肠瘘、痔疮、慢性腹泻、腹痛、顽固性便秘、营养不良、肿瘤放化疗后腹泻等病诊疗。接诊患者来自全国、澳洲、欧洲和美国。

发表论文

Fecal Microbiota Transplantation-standardization Study Group. Nanjing consensus on methodology of washed microbiota transplantation. Chin Med J (Engl) 2020 Jul 21. doi: 10.1097/CM9.0000000000000954 Lead author
Ding X, Li Q, Li P, Chen X, Xiang L, Bi L, Zhu J, Huang X, Cui B, Zhang F. Fecal microbiota transplantation: A promising treatment for radiation enteritis? Radiother Oncol 2020.143：12-18
Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcells C, Cui B, Cheng L, Ji G, Zhang F. Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell 2020;11(4):251-266
Xiang L, Ding X, Li Q, Wu X, Dai M, Long C, He Z, Cui B, Zhang F. Efficacy of faecal microbiota transplantation in Crohn's disease: a new target treatment? Microb Biotechnol 2020;13(3):760-769
Dai M, Liu Y, Cheng W, Buch H, Shan Y, Chang L, Bai Y, Shen C, Zhang X, Huo Y, Huang D, Yang Z, Hu Z, He X, Pan J, Hu L, Pan X, Wu X, Deng B, Li Z, Cui B, Zhang F*. Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients. Crit Care 2019 Oct 21;23(1):324
Wu X, Dai M, Buch H, Bai J, Long W, Long C, Tang X, Tu H, Zhang R, Zhu C, Yang S, Cui B, Ji G, Zhang F. The recognition and attitudes of postgraduate medical students towards fecal microbiota transplantation: a questionnaire study. Therap Adv Gastroenterol 2019 Sep 2;12:1756284819869144
Zhang F, Zhang T, Zhu H, Borody TJ. Evolution of Fecal Microbiota Transplantation in Methodology and Ethical Issues. Curr Opin Pharmacol 2019;49:11-16
Wu X, Zhang T, Chen X, Ji G, Zhang F. Microbiota Transplantation: Targeting Cancer Treatment. Cancer Lett 2019 Jun 28;452:144-151
Ding X, Li Q, Li P, Zhang T, Cui B, Ji G, Lu X, Zhang F. Long-term safety and efficacy of fecal microbiota transplant in active ulcerative colitis. Drug Safety 2019;42(7):869–880
Li P, Zhang T, Xiao Y, Tian L, Cui1 B, Ji G, Liu YY, Zhang F. Timing for the second fecal microbiota transplantation to maintain the long-term benefit from the first treatment for Crohn’s disease. Appl Microbiol Biotech 2019;103(1):349-360
Zhang F, Cui B, He X, Nie Y, Wu K, Fan D, FMT-standardization Study Group. Microbiota transplantation: Concept, methodology and strategy. Protein Cell 2018;9(5):462-473
Long C, Yu Y, Cui B, Jagessar SA, Zhang J, Ji G, Huang G, Zhang F. A novel quick transendoscopic enteral tubing in mid-gut: technique and training with video. BMC Gastroenterol 2018;18(1):37
Peng Z, Xiang J, He Z, Zhang T, Xu L, Cui B, Li P, Huang G, Ji G, Nie Y, Wu K, Fan D, Zhang F. Colonic transendoscopic enteral tubing: A novel delivering way for fecal microbiota transplantation. Endosc Int Open 2016;04(06):E610-E613
Cui B, Li P, Xu L, Peng Z, Xiang J, He Z, Zhang T, Ji G, Nie Y, Wu K, Fan D, Zhang F. Step-up fecal microbiota transplantation (FMT) strategy. Gut Microbes 2016;7(4):323-328
Cui B, Li P, Xu L, Zhao Y, Wang H, Peng Z, Xu H, Xiang J, He Z, Zhang T, Nie Y, Wu K, Fan D, Ji G, Zhang F. Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis. J Transl Med 2015;13(1):298
Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, Huang G, Liu Z, Wu P, Fan Z, Ji G, Wang X, Wu K, Fan D, Zhang F. Fecal microbiota transplantation through mid-gut for refractory Crohn’s disease: Safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol 2015;30(1):51-58

张晓燕

北京大学医学博士，博士生导师，教授，国家优青获得者。现任大连医科大学医学科学研究院副院长、特聘研究员。致力于研究核受体包括FXRs、LXRs和PPARs等在水盐代谢调控及高血压发生中的作用及机制、在肝脏脂质代谢调节及脂肪肝发生中的作用及机制、在肾脏生理和病生理功能调节及糖尿病肾病发生中的作用和机制。现主持国家自然科学基金优秀青年科学基金项目和国家自然科学基金面上项目，参与科技部脂肪肝及高脂血症防治973项目、国家自然科学基金委糖代谢研究重大项目等。已完成一项国家自然科学基金青年基金和深圳市科技创新委员会科技研发项目。入选2017年“辽宁省特聘教授”。在Proc Natl Acad Sci, J Am Soc Nephrol等国际知名杂志上发表论文40余篇。Scientific Reports, AJP-Endocrinology and Metabolism, Journal of Diabetes等国外期刊的审稿人。担任《生理学报》常务编委、《医学生理学》（第四版）规划教材编委，中国生理学会肾脏生理专业委员会、整合生理专业委员会和青年工作委员会委员。

发表论文 (*通讯作者, #第一作者)

Hu Xu#, Bingying Fang#, Shengnan Du#, Sailun Wang, Qingwei Li, Xiao Jia, Chengzhen Bao, Lan Ye, Xue Sui, Lei Qian, Zhilin Luan, Guangrui Yang, Feng Zheng, Nanping Wang, Lihong Chen*, Xiaoyan Zhang*, Youfei Guan*. Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI Insight 2020 Jul 9;5(13):e138505
Wang B#, Zhang H, Luan Z, Xu H, Wei Y, Zhao X, Xing M, Huo X, Zhang J, Su W, Guan Y, Zhang X*. Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver. Exp Cell Res 2020 May 1;390(1):111949
Xu H#, Du S#, Fang B#, Li C#, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X*, Gustafsson JÅ*, Guan Y*. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A 2019 Apr 23;116(17):8457-8462
Xu S#, Huang S#, Luan Z#, Chen T, Wei Y, Xing M, Li Y, Du C, Wang B, Zheng F, Wang N, Guan Y*, Gustafssond J-A*, Zhang X*. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress. Proc Natl Acad Sci U S A 2018 May 22;115(21):5600-5605
Peng J#, Yu J, Xu H, Kang C, Shaule PW, Guan Y, Zhang X*, Su W*. Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element- Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability. Cell Physiol Biochem 2018;47(2):784-799
Zhang X#, Yang W#, Wang J#, Meng Y, Guan Y, Yang J. FAM3 gene family: a promising therapeutical target for NAFLD and type 2 diabetes. Metabolism 2018 Apr;81:71-82
Zhou Y#, Yu J, Liu J, Cao R, Su W, Li S, Ye S, Zhu C, Zhang X, Xu H, Chen H, Zhang X*, Guan Y*. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta Mol Basis Dis 2018 Mar;1864(3):860-870
Li Y#, Wei Y, Zheng F, Guan Y*, Zhang X*. Prostaglandin E2 in the Regulation of Water Transport in Renal Collecting Ducts. Int J Mol Sci 2017 Nov 27;18(12):2539 (Invited review)
Zhang X#, Li S#, Zhou Y#, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson JA*, Guan Y*. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A 2017 Mar 21;114(12):3181-3185
Wen Su#, Jun Peng#, Chun-jiong Wang, Sha Li, Yu-bing Dai, Hu Xu, Min Gao, Xiong-zhong Ruan, Jan-Åke Gustafsson, You-fei Guan, Xiao-yan Zhang*. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab 2017 Apr 1;312(4):E357-E367
Su W#, Huang SZ, Gao M, Kong XM, Gustafsson JA, Xu SJ, Wang B, Zheng F, Chen LH, Wang NP, Guan YF, Zhang XY*. Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts. Am J Physiol Renal Physiol 2017 Apr 1;312(4):F619-F628
Zhang X#*, Wang B, Guan Y. Nuclear Receptor Regulation of Aquaporin-2 in the Kidney. Int J Mol Sci 2016,17(7):1105

张星

空军军医大学航空航天医学系副教授
研究方向是生活方式与心血管疾病
地址：陕西省西安市长乐西路169号
Tel: 86-29-83 (office); 86-15309225008 (mobile)
E-mail: zhangxing@fmmu.edu.cn; lbmed@163.com

学习和工作经历
2018.2-至今第四军医大学，航空航天医学系，副教授
2015.2-2018.2, 第四军医大学航空航天医学系，讲师
2013.6-2015.2, 第四军医大学基础部，讲师
2009.9–2013.6, 第四军医大学，生理学博士, 导师: 高峰，程和平
2006.9–2009.6, 第四军医大学，生物医学工程硕士, 导师: 罗二平
2001.9–2006.7, 第四军医大学，生物医学工程学士

发表论文 (# first author; * corresponding author)

Li J#, Xu J#, Qin X, Yang H, Han J, Jia Y, Zhu H, Zhu L, Li J, Xie W, Hu D, Zhang X*, Gao F*. Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice. Biochim Biophys Acta Mol Basis Dis 2019 Feb 1;1865(2):275-284
Guo Y, Wang Z, Qin X, Xu J, Hou Z, Yang H, Mao X, Xing W, Li X, Zhang X*, Gao F*. Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing opa1 processing in the failing heart. Cardiovasc Res 2018 Jun 1;114(7):979–991
Zhang X, Gao F. Exercise is good for the heart, but the intensity matters. Am J Physiol Heart Circ Physiol 2017 Sep 1;313(3):H546-H547
Li T, Xu J, Qin X, Hou Z, Guo Y, Liu Z, Wu J, Zheng H, Zhang X*, Gao F*. Glucose oxidation positively regulates glucose uptake and improves cardiac function recovery after myocardial reperfusion. Am J Physiol Endocrinol Metab 2017 Nov 1;313(5):E577-E585
Wang X#, Zhang X#, Wu D#, Huang Z, Hou T, Jian C, Yu P, Lu F, Zhang R, Sun T, Li J, Qi W, Wang Y, Gao F, Cheng H. Mitochondrial flashes regulate ATP homeostasis in the heart. Elife 2017 Jul 10;6:e23908
Wang X#, Zhang X#, Huang Z#, Wu D, Liu B, Zhang R, Yin R, Hou T, Jian C, Xu J, Zhao Y, Wang Y, Gao F, Cheng H. Protons trigger mitochondrial flashes. Biophys J 2016 Jul 26;111(2):386-394
Xu J, Qin X, Cai X, Yang L, Xing Y, Li J, Zhang L, Tang Y, Liu J, Zhang X*, Gao F*. Mitochondrial jnk activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion. Biochim Biophys Acta 2015 Feb;1852(2):262-270
Zhang X, Gao F. Imaging mitochondrial reactive oxygen species with fluorescent probes: Current applications and challenges. Free Radic Res 2015 Apr;49(4):374-382
Zhang X#, Xu J#, Cai X#, Ji L, Li J, Cao B, Hu D, Li Y, Wang H, Xiong L, Xiao R, Gao F. Acute insulin resistance mediated by advanced glycation endproducts in severely burned rats. Crit Care Med 2014 Jun;42(6):e472-e480
Zhang X#, Huang Z#, Hou T, Xu J, Wang Y, Shang W, Ye T, Cheng H, Gao F, Wang X. Superoxide constitutes a major signal of mitochondrial superoxide flash. Life Sci 2013 Aug 6;93(4):178-186
Hou T#, Zhang X#, Xu J, Jian C, Huang Z, Ye T, Hu K, Zheng M, Gao F, Wang X, Cheng H. Synergistic triggering of superoxide flashes by mitochondrial ca2+ uniport and basal reactive oxygen species elevation. J Biol Chem 2013 Feb 15;288(7):4602-4612

张瑛

北京大学神经科学研究所、基础医学院神经生物学系，副教授。研究论文（第一或通讯作者）发表在Journal of Neuroscience(2018, 2012, 2010), Experimental Neurology(2017)和Neuropsychopharmacology(2014)等期刊，先后受到国家自然科学基金委面上项目（2020~2023, 2018~2021, 2014~2017）、青年项目，北京市高校青年英才计划和教育部新教师基金等基金资助。兼任《生理科学进展》编委，国际期刊Experimental Neurology, Biochimica et Biophysica acta - General Subjects等审稿人。参与“以器官系统为中心”翻译教材《神经系统—基础与临床》（第2版），《神经生物学》（于龙川主编）等教材编写。曾获2019北大医学教育论坛论文一等奖、2018年度韩济生疼痛医学论文二等奖、北京大学绿叶生物医药杰出青年学者奖、北京大学医学部优秀人才奖励计划青年学者、北京大学医学部教学优秀和北京大学医学部优秀教学管理奖等奖励。

发表论文 (# first author; * corresponding author)

Guo YP, Zhi YR, Liu TT, Wang Y, Zhang Y*. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats. Front Mol Neurosci 2019 Jan 25;12:5 eCollection 2019
Huang T, Lin SH, Malewicz NM, Zhang Y, Zhang Y, Goulding M, LaMotte RH, Ma Q*. Identifying the pathways required for coping behaviours associated with sustained pain. Nature 2019 Jan;565(7737):86-90
Tian NX*, Xu Y*, Yang JY, Li L, Sun XH, Wang Y, Zhang Y*. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci 2018 Feb 14;38(7):1756-1773
Huang M, Cheng G, Tan H, Qin R, Zou YM, Wang YCA, Zhang Y. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol 2017;295:66-76
Wang GQ*, Cen C*, Li C*, Cao S*, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA, Wang Y. Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun 2015;16(6):7660
Zhang Y*, Wang N*, Su P, Lu J, Wang Y. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull 2014;30(6):1025-1035
Wang N*, Su P*, Zhang Y*, Lu J*, Xing BM, Kang K, Li WQ, Wang Y. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol 2014;39(5):1290-1301
Li Y*, Hu F*, Chen HJ*, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang Y. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal 2014;7(331):ra61
Xing BM*, Yang YR*, Du JX*, Chen HJ, Qi C, Huang ZH, Zhang YCA, Wang Y. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci 2012;32(42):14709-14721
Zhu YB*, Kang K*, Zhang Y, Qi C, Li G, Yin DMCA and Wang Y. PLD1 negatively regulates dendritic branching. J Neurosci 2012;32(23):7960-7969
Chen HJ*, Xie WY*, Hu F, Zhang Y, Wang J, Wang Y. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity. Neurosci Bull 2012;28(2):182-192
Zhang Y*, Su P*, Liang P, Liu T, Liu X, Liu XY, Zhang B, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci 2010;30(22):7575-7586

张勇

运动生理学博士，二级教授。天津市运动生理学与运动医学重点实验室主任。天津体育学院原副院长。现担任中国生理学会应激生理专业委员会主任委员、应用生理专业委员会委员；中国体育科学学会理事、运动生理与生物化学分会副主任委员（应用基础研究学组组长）；华人运动生理与体适能学者学会副理长；亚洲线粒体医学研究学会理事。

主要研究方向是细胞与分子运动生理学。1、运动氧化应激与线粒体生物学；2、线粒体稳态调控与整合运动生理学。先后主持国家自然科学基金10项（其中重大国际合作项目1项）、天津市社会发展重大科技攻关项目、天津市自然科学基金重点项目、国家体育总局应用基础项目以及国际合作和企业委托项目等30余项。在国内外重要学术期刊发表研究论文和综述100余篇。

发表论文

Wang Y, Bo H, Zhang Y*. Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex. Acta Physiologic Sinica 2020 Apr 25;72(2):205-219
Wu JB, Zhang Y*. Research progress in relation between Irisin and disease. Progress in Physiological Science. 2018;49(6):465-470
Zhao F, Pang WT, Zhang ZY, Zhao JL, Wang X, Liu Y, Wang X, Feng ZH, Zhang Y, Sun WY, Liu JK. Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat diet-induced obesity rats. J Nutr Biochem 2016 Jun;32:20-28
Ji LL*, Kang CH, Zhang Y. Exercise-induced Hormesis and Skeletal Muscle Health. Free Radic Biol Med 2016 Sep;98:113-122
Wang X, Feng ZH, Wang XQ, Yang L, Han SJ, Cao K, Xu J, Zhao J, Zhang Y*, Liu JK*. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity through the modulation of mitochondrial homeostasis. Diabetologia 2016 Jun;59(6):1287-1296
Li HY, Miao WG, Ma JF, Xu Z, Bo H, Li JY, Ji LL, Zhang Y*. Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via NLRP3 inflammasome activation with mitophagy. Oxid Med Cell Longev 2016;2016:1987149
Bo H, Jiang N, Zhang ZY, Ji LL, Zhang Y*. Exercise and Health: From evaluation of health promoting effect exercise to exploration of exercise minetics. Progress in Physiological Sciences 2014 Aug;45(4):251-256
Bo H, Kang WM, Li HS, Wang X, Ji LL, Zhang Y*. Exercise-induced neuroprotection of hippocampus in APP/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase. Oxid Med Cell Longev 2014;2014:834502
Wang X, Li H, Zheng A, Yang L, Liu J, Chen C, Tang Y, Zou X, Li Y, Long JG, Liu JK, Zhang Y*, Feng ZH*. Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate. Cell Death Dis 2014 Nov 13;5(11):e1521
Jiang N, Bo H, Song C, Guo J, Zhao F, Feng H, Ding H, Ji LL, Zhang Y*. Increased vulnerability with aging to MPTP: the mechanisms underlying mitochondrial dynamics. Neurol Res 2014 Aug;36(8):722-732
Ji LL, Zhang Y. Antioxidant and Anti-inflammatory Effects of Exercise: Role of Redox Signaling. Free Radic Res 2014 Jan;48(1):3-11
Bo H, Jiang N, Ji LL, Zhang Y. Mitochondrial redox metabolism in aging: Effect of exercise interventions. J Sport Health Sci 2013 Jun;2(2):67-74
Hong Feng, Chounghun Kang, Jonathan R. Dickman, Ryan Koenig, Iwalola Awoyinka, Yong Zhang*, Lili Ji*. Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade. Exp Physiol 2013 Mar;98(3):784-795
Bo H, Zhang Y*, Ji LL*. Redefining the Role of Mitochondria in Exercise: A Dynamic Remodeling. Ann N Y Acad Sci 2010 Jul;1201:121-128 (invited review)
Liao P, Zhou JP, Ji LL* Zhang Y*. Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-α. Am J Physiol Regul Integr Comp Physiol 2010 Mar;298(3):R599-R607
Ding H, Jiang N, Liu HJ, Liu DX, Wen L, Liu SS, Ji LL* Zhang Y*. Dynamic Response of Mitochondrial Fusion and Fission Protein Gene Expression to Exercise in Rat Skeletal Muscle. Biochim Biophys Acta 2010 Mar;1800(3):250-256

郑宏庭

主任医师，教授，博导，国家杰青获得者，陆军军医大学第二附属医院（新桥医院）内分泌科主任，重庆市高校重点实验室主任。重庆市高校创新群体负责人，重庆英才·创新领军人才，重庆市学术技术带头人，重庆市人大代表，全军与重庆市优博导师，军队院校育才银奖、科技英才、优秀专业技术人才岗位津贴获得者。中华医学会内分泌学分会全国委员，中国医师协会内分泌代谢科医师分会全国委员，JCEM、中华内分泌代谢杂志、生理学报编委。主持国家杰出青年科学基金等各类科研课题20余项，累计科研经费4000余万元。获2019年CODHy Young Scientist Award（1）、2018年中国糖尿病十大研究奖（1）、2016年中国糖尿病十大研究奖（1）、2013年中华医学科技奖二等奖（5）、2007年全军医疗成果三等奖（1）等奖项。以通讯/第一作者在Science Transl Med, Cell子刊Trends Endocrin Met, EMBO Mol Med, Hepatology, Diabetes (3篇), JCEM, EbioMedicine等期刊发表论文多篇，其中3篇入选F1000。

发表论文

Wu T#, Zhang Q#, Wu S, Hu W, Zhou T, Li K, Liu D, Gu HF, Zheng H, Zhu Z, Li L*, Yang G*. CILP-2 is a novel secreted protein and associated with insulin resistance. J Mol Cell Biol 2019 Dec 19;11(12):1083-1094
Yang M#, Liang Z#, Yang M, Jia Y, Yang G, He Y, Li X, Gu HF, Zheng H, Zhu Z, Li L*. Role of bone morphogenetic protein-9 in the regulation of glucose and lipid metabolism. FASEB J 2019 Sep;33(9):10077-10088
Lin Y, Liang Z, He L, Yang M, Liu D, Gu HF, Liu H, Zhu Z, Zheng H, Li L*, Yang G*. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway. Cell Commun Signal 2019 Jan 25;17(1):8
Zhang K, Guo X, Yan H, Wu Y, Pan Q, Shen JZ, Li X, Chen Y, Li L, Qi Y, Xu Z, Xie W, Zhang W, Threadgill D, He L, Villarreal D, Sun Y, White MF, Zheng H, Guo S*. Phosphorylation of forkhead protein FoxO1 at Ser253 regulates glucose homeostasis in mice. Endocrinology 2019 May 1;160(5):1333-1347
Zhang C#, Luo X#, Chen J#, Zhou B, Yang M, Liu R, Liu D, Gu HF, Zhu Z, Zheng H, Li L*, Yang G*. Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK- PPARγ-CD36 Pathway. Diabetes 2019 Oct;68(10):1902-1914
Cui Y#, Wu H#, Li Q#, Liao J, Gao P, Sun F, Zhang H, Lu Z, Wei X, He C, Ma T, Wei X, Chen X, Zheng H, Yang G, Liu D, Zhu Z*. Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension. Hypertension 2019 Oct;74(4):1021-1032
Jia Y#, Niu D#, Li Q#, Huang H, Li X, Li K, Li L, Zhang C, Zheng H, Zhu Z, Yao Y, Zhao X, Li P*, Yang G*. Effective gene delivery of shBMP-9 using polyethyleneimine-based core-shell nanoparticles in an animal model of insulin resistance. Nanoscale 2019;11(4):2008-2016
Zheng Y#, Qu H#, Xiong X#, Wang YR#, Liu XF#, Zhang LL, Liao XY, Liao Q, Sun Z, Ouyang Q, Yang GY, Zhu ZM, Xu J, Zheng HT*. Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis. Hepatology 2019 Jul;70(1):84-97
Recommended by F1000 Prime http://f1000.com/prime/734876838
Comment by Maria Dalamaga and Junli Liu in Metabolism Open 2019
Zhang R#, Wang H#, Tong Q, Xu J, Long M, Wang X, Wang M, Zhou X, Zheng H*. Tissue biopsy in the diagnosis of chronic tuberculous wounds in diabetes mellitus. Diabetic Medicine 2019 Jul;36(7):908-910
Liao X#, Song L#, Zeng B#, Liu B, Qiu Y, Qu H, Zheng Y, Long M, Zhou H, Wang Y, Du Y, Xu J, Shen R, Tong Q, Cai L, Li X, Guo S, Yang G, Zhu Z, Pu X, Wei H*, Zheng H*. Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis. EBioMedicine 2019 Jun;44:665-674
Mi Q#, Li Y#, Wang M, Yang G, Zhao X, Liu H, Zheng H, Li L*. Circulating C1q/TNF-related protein isoform 15 is a marker for the presence of metabolic syndrome. Diabetes Metab Res Rev 2019 Jan;35(1):e3085
Liu XF#, Qu H#, Zheng Y#, Liao Q#, Zhang LL, Liao XY, Xiong X, Wang YR, Zhang R, Wang H, Tong Q, Liu ZQ, Dong H, Yang GY, Zhu ZM, Xu J, Zheng HT*. Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration. EMBO Mol Med 2018 Dec;10(12):e9390 (cover article)
Recommended by F1000 Prime https://f1000.com/prime/734369687
Lu Z#, Wei X#, Sun F#, Zhang H, Gao P, Pu Y, Wang A, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D, Zhu Z*. Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discov 2018 Sep 25;4:58
Wang M#, Tang X#, Li L, Liu D, Liu H, Zheng H, Deng W, Zhao X*, Yang G*. C1q/TNF-related protein-6 is associated with insulin resistance and the development of diabetes in Chinese population. Acta Diabetol 2018 Dec;55(12):1221-1229
Huang H#, Wang W#, Yang G, Zhang Y, Li X, Liu H, Zhang L, Zheng H, Li L*. Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans. J Am Soc Hypertens 2018 May;12(5):372-380
Feiyu Jiang, Min Yang, Xili Zhao, Rui Liu, Gangyi Yang, Dongfang Liu, Hua Liu, Hongting Zheng, Zhiming Zhu, Ling Li*. C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components. Int J Endocrinol 2018 Nov 22;2018:7201473
Long M#, Cai LQ#, Li WJ, Zhang LL, Guo SD, Zhang R, Zheng Y, Liu XF, Wang M, Zhou XL, Wang H, Li X, Li L, Zhu ZM, Yang GY, Zheng HT*. DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring. Diabetes 2018 Mar;67(3):518-531
Comment by Max Bingham in the same issue of Diabetes 2018 Mar;67(3):349-350
Qu H#, Qiu Y#, Wang Y#, Liao Y, Zheng Y, Zheng H*. Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance. Diabetes Metab 2018 Dec;44(6):488-492
Li K#, Liao X#, Wang K#, Mi Q, Zhang T, Jia Y, Xu X, Luo X, Zhang C, Liu H, Zhen HT, Li L, Yang G*. Myonectin Predicts the Development of Type 2 Diabetes. J Clin Endocrinol Metab 2018;103(1):139-147
Li K#, Liao X#, Wang K#, Mi Q, Zhang T, Jia Y, Xu X, Luo X, Zhang C, Liu H, Zheng H, Li L, Yang G*. Response to Letter to the Editor: "Myonectin Predicts the Development of Type 2 Diabetes". J Clin Endocrinol Metab 2018 Nov 1;103(11):4040-4041
Wei Q, Zhou B, Yang G, Hu W, Zhang L, Liu R, Li M, Wang K, Gu HF, Guan Y, Zhu Z, Zheng H, Peng J, Li L*. JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell Death Dis 2018 Aug 28;9(9):859
Lu Zongshi#, Cui Yuanting#, Wei Xing#, Gao Peng*, Zhang Hexuan, Wei Xiao, Li Qiang, Sun Fang, Yan Zhencheng, Zheng Hongting, Yang Gangyi, Liu Daoyan, Zhu Zhiming*. Deficiency of PKD2L1(TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload. Cell Rep 2018 Aug 7;24(6):1639-1652
Wu Y#, Pan Q#, Yan H#, Zhang K#, Guo X, Xu Z, Yang W, Qi Y, Guo CA, Hornsby C, Zhang L, Zhou A, Li L, Chen Y, Zhang W, Sun Y, Zheng H, Wondisford F, He L, Guo S*. Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis. Diabetes 2018 Nov;67(11):2167-2182
Fang X#, Zhang T#, Yang M, Li L, Zhang C, Hu W, Fan X, Liu H, Zhu Z, Liu D, Zheng H, Gu HF, Liu R*, Yang G*. High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome. Cell Physiol Biochem 2018;51(5):2041-2051
Duan L#, Shen RF#, Song LY, Liao Y, Zheng HT*. A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report. BMC Endocr Disord 2018 Apr 27;18(1):23
Liao X#, Song L#, Zhang L, Wang H, Tong Q, Xu J, Yang G, Yang S*, Zheng HT*. LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. Mol Cell Endocrinol 2018;470:160-167
Wang Y#, Qu H#, Xiong X, Qiu Y, Liao Y, Chen Y*, Zheng Y*, Zheng H*. Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion. Mediators Inflamm 2018 Mar 20;2018:9471583
Li X, Liao M, Shen R, Zhang L, Hu H, Wu J, Wang X, Qu H, Guo S, Long M*, Zheng H*. Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases. Mediators Inflamm 2018 Nov 6;2018:7375294
Wang Q#, Long M#, Qu H, Shen R, Zhang R, Xu J, Xiong X, Wang H, Zheng H*. DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Diabetes Res 2018 Jan 8;2018:5308582
Duan L#*, Fang F#, Fu WL, Fang ZQ, Wang H, Yu SC, Tang ZL, Liu ZQ, Zheng HT*. Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report. BMC Endocr Disord 2017 Feb 13;17(1):9
Long M#, Li X#, Li L#, Dodson M, Zhang DD, Zheng HT*. Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. Trends Endocrinol Metab 2017;28(11):818-830
Qu H#, Zheng Y#, Wang Y#, Zhang R, Ruan X, Yang G, Liu Z, Zheng HT*. Global and Regional Effects of Bladder Cancer Risk Associated with Pioglitazone Therapy in Patients with Diabetes. Sci Rep 2017;7(1):15804
Wang H#, Du L#, Wu T, Yang G, Hu W, Wang H, Yang M, Liu D, Gu HF, Zhu Z, Zheng H, Li L*. Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro. Oncotarget 2017;8(57):96604-96614
Xu X#, Li X#, Yang G#, Li L, Hu W, Zhang L, Liu H, Zheng H, Tan M*, Zhu D*. Circulating bone morphogenetic protein-9 in relation to metabolic syndrome and insulin resistance. Sci Rep 2017 Dec 13;7(1):17529
Lei L#, Li K#, Li L#, Fang X, Zhou T, Zhang C, Luo Y, Liu H, Li X, Zheng H, Zhang L, Yang G*, Gao L*. Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin. Nutr Metab (Lond) 2017 Aug 14;14:53
Su Q#, Liu C#, Zheng HT, Zhu J, Li PF, Qian L, Yang WY*. Comparison of Insulin Lispro Mix 25 with Insulin Lispro Mix 50 as Insulin Starter in Chinese Patients with Type 2 Diabetes Mellitus (CLASSIFY Study): A Subgroup Analysis of a Phase 4, Open-Label, Randomized Trial. J Diabetes 2017;9(6):575-585
Xu XH#, Lai YR#, Yang GY, Yang ML, Li L, Zhang Q, Liu H, Zheng HT, Zhu DP*. Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome. Medicine (Baltimore) 2016 Dec;95(49):e5524
Chen C#, Zeng Y#, Xu J, Zheng HT, Liu J, Fan R, Zhu W, Yuan L, Qin Y, Chen S, Zhou Y, Wu Y, Wan J, Mi M*, Wang J*. Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus. Exp Ther Med 2016 Aug;12(2):1232-1242
Wang H#, Liu XF#, Long M#, Huang Y#, Zhang LL, Zhang R, Zheng Y, Liao XY, Wang YR, Liao Q, Li WJ, Tang ZL, Tong Q, Wang XC, Fang F, Rojo de la Vega M, Ouyang Q, Zhang DD*, Yu SC*, Zheng HT*. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Sci Transl Med 2016 Apr 13;8(334):334ra51
Recommended by F1000 Prime http://f1000.com/prime/726286483
Commented by Cell Metab 2016 Jun 14;23(6):959-960
Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou SW, Wong PK, Wondrak GT*, Zheng HT*, Zhang DD*. An essential role of NRF2 in diabetic wound healing. Diabetes 2016;65(3):780-793
Wang H, Rojo de la Vega M, Zhang DD*, Yu SC*, Zheng HT*. Response to comment on "NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis". Science Transl Med 2016;8(349):349lr1
Zheng HT. Some antioxidant antidiabetic agents may link to tumor metastasis in mice. Science Foundation in China 2016;24(3):53
Zhang JL#, Liu GK#, Ruan Y#, Wang JL#, Zhao K, Wan Y, Liu B, Zheng HT, Peng T, Wu W, He P, Hu FQ*, Jian R*. Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency. Nat Commun 2014 Oct 6;5:5042
Jiang T#*, Tian F#, Zheng HT, Whitman SA, Lin YF, Zhang ZG, Zhang N, Zhang DD*.Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response. Kidney Int 2014;85(2):333-343
Samantha A Whitman, Min Long, Georg Wondrak, Zheng HT*, Donna D. Zhang*. Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res 2013;319(17):2673-2683
Tong Q#, Duan L#, Xu ZH, Wang H, Wang XC, Li ZJ, Zhang WZ, Zheng HT*. Improved Insulin Secretion Following Intrapancreatic UCB Transplantation in Patients With T2DM. J Clin Endocrinol Metab 2013;98(9):E1501-E1504
Zheng HT, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang DY, Zhang DD*. Therapeutic Potential of Nrf2 Activators in Streptozotocin -Induced Diabetic Nephropathy. Diabetes 2011;60(11):3055-3066
Comments by Diabetes in the same issue Diabetes 2011 Nov;60(11):2683-2684
Liu JB, Jia L, Li BR, Lan LZ, Ge Q, Zheng HT, Deng HC*. Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats. Mol Med Rep 2010 Mar-Apr;3(2):323-328

钟春玖

医学博士、博士研究生导师、复旦大学附属中山医院神经内科主任医师、教授，复旦大学医学神经生物学国家重点实验室和脑科学研究院研究人员
地址：上海市医学院路136号复旦大学附属中山医院3号楼5楼神经内科病房，上海200032
电话：(86) 21-54237920
邮箱：zhongcj@163.com

学习和工作经历
2006-至今：主任医师/教授，神经内科，复旦大学附属中山医院
2000-2006：副主任医师/副教授，神经内科，复旦大学附属中山医院
1993-2000：主治医师，神经内科，(前)上海医科大学中山医院
1992-1993：住院医师，神经内科，(前)上海医科大学中山医院
1986-1989：住院医师，内科，安徽省无为县人民医院
2008.01：医学博士，复旦大学，神经病学
1992.07：医学硕士，上海医科大学，神经病学
1986.07：医学学士，安徽医科大学，临床医学

学术及社会任职
中华医学会上海神经病学分会运动障碍学组委员、世界卫生组织上海健康教育与健康促进合作中心帕金森病健康教育基地医疗专家委员会委员，Neuroscience Bulletin (Associate editor), BMC Neurology (Associate editor), Brain, Journal of Neurology, Journal of Alzheimer’s disease, Neuroscience Letter

发表论文

Zhang J, Wang L, Deng X, Fei G, Jin L, Pan X, Cai L, Albano AD, Zhong C*. Five-minute cognitive test as a new quick screening of cognitive impairment in the elderly. Aging Dis 2019 Dec 1;10(6):1258-1269
Wang L, Pan X, Fei G, Wang C, Wan W, Sang S, Wang H, Wang Z, Zhong C. Decreased function of delayed recall in non-demented elderly subjects with apolipoprotein E ε4 allele. Front Aging Neurosci 2019 Mar 29;11:71
Zhao L, Cheng X, Zhong C. Implications of successful symptomatic treatment in Parkinson's disease for therapeutic strategies of Alzheimer's disease. ACS Chem Neurosci 2019 Feb 20;10(2):922-930
Cheng X, Ma D, Fei G, Ma Z, Xiao F, Yu Q, Pan X, Zhou F, Zhao L, Zhong C. A single-step method for simultaneous quantification of thiamine and its phosphate esters in whole blood sample by ultra-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2018 Sep 15;1095:103-111
Sang S, Pan X, Chen Z, Zeng F, Pan S, Liu H, Jin L, Fei G, Wang C, Ren S, Jiao F, Bao W, Zhou W, Guan Y, Zhang Y, Shi H, Wang Y, Yu X, Wang Y, Zhong C. Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not. Alzheimers Res Ther 2018;10(1):26
Liu H, Sang S, Lu Y, Wang Z, Yu X, Zhong C. Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata. Sci Rep 2017;7(1):5342
Pan X, Fei G, Lu J, Jin L, Pan S, Chen Z, Wang C, Sang S, Liu H, Hu W, Zhang H, Wang H, Wang Z, Tan Q, Qin Y, Zhang Q, Xie X, Ji Y, Cui D, Gu X, Xu J, Yu Y, Zhong C. Measurement of blood thiamine metabolites for Alzheimer's disease diagnosis. EBioMedicine 2016;3:155-162
Zhao L, Gong N, Liu M, Pan X, Sang S, Sun X, Yu Z, Fang Q, Zhao N, Fei G, Jin L, Zhong C, Xu T. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiol Aging 2014;35(12):2736-2745
Chen Z, Zhong C. Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol 2013;108:21-43
Jin L, Wang J, Zhao L, Jin H, Fei G, Zhang Y, Zeng M, Zhong C. Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain 2011;134(Pt 1):50-58
Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, Xu Z, Dong W, Qin Y, Fei G, Zhong C, Xu TL. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 2010;133(Pt 5):1342-1351

周嘉伟

中国科学院神经科学研究所研究员。曾获基金委“杰出青年基金”、上海市领军人才计划资助。获得首届全国创新争先奖状、赛诺菲中国神经科学优秀学者奖、药明康德生命化学研究奖、中科院优秀导师奖、中科院优秀研究生指导老师奖、国务院特殊津贴等奖励。长期从事神经退行性疾病帕金森病发病机理、多巴胺能神经元发育以及多巴胺能神经传导的分子细胞基础的研究。阐述了多巴胺受体在星形胶质细胞介导的神经炎症调节过程中的作用；揭示了新的多巴胺转运体调节的分子机制；发现了胶质细胞源性神经营养因子GDNF受体家族新成员GFRAL，该受体后被他人证明是在机体代谢调节过程中发挥重要作用的GDF15的受体。在Nature, Nat Neurosci, PNAS, BMC Med, J Neurosci等国际学术期刊上发表研究论文五十多篇。兼任Front Aging Neurosci (Associate Editor), Transl Neurodegener (Section Editor), ACS Chem Neurosci, ASN Neuro, 生理学报, 生命科学等国内外学术期刊编委。还兼任中国生理学会副理事长、中国神经科学学会常务理事、神经胶质细胞分会主任委员和神经退行性疾病分会副主任委员、上海市神经科学学会副理事长等。

发表论文

Zhang SZ#, Wang QQ#, Yang QQ, Gu HY, Yin YQ, Li YD, Hou JC, Chen R, Sun QQ, Sun YF, Hu G, Zhou JW*. NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis. BMC Med 2019 Nov 15;17(1):204 (#co-first author)
Lu SZ, Guo YS, Liang PZ, Zhang SZ Yin S, Yin YQ, Wang XM, Ding D, Gu XS and Zhou JW. Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Transl Neurodegener 2019 Jan 18;8:3
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW*. Extracellular αB-crystallin modulates the inflammatory responses. Biochem Biophys Res Commun 2019 Jan 1;508(1):282-288
Zhu SY#, Zhao CJ#, Wu YY#, Yang QQ, Shao AY, Wang TP, Wu JF, Yin YQ, Li YD, Hou JC, Zhang XH, Zhou GM, Gu XS, Wang XM, Bustelo XR, Zhou JW*. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci 2015 Aug;18(8):1084-1093 (#co-first author)
Yan Hu, Sen Li, Hua Jiang, Ming-Tao Li*, Jia-Wei Zhou*. Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse. Neurosci Bull 2014 Jun;30(3):425-432
Shao W#, Zhang SZ#, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Liu YJ, Huang YY, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW*. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature 2013 Feb 7;494(7435):90-94 (#co-first author)
Highlighted in Nat Rev Immunol; Sci Signal; SciBX: Science-Business eXchange, F1000Prime, Nature China

周怡

副研究员，博士生导师，中山大学附属第一医院肾内科
地址：广东省广州市中山二路58号（邮编：510080）
电话：(86)-020-8755766 (office); 151-1209-2273 (cell)
邮箱：zhouyi39@mail.sysu.edu.cn; zhouyisysu@163.com

学习和工作经历
2017.12—至今副研究员，中山大学附属第一医院肾内科
2015.07—2016.10 博士后，哈佛医学院，波士顿儿童医院感染科
2011.10—2015.06 博士后，哈佛医学院，Brigham and Women’s Hospital
2013.01—2017.12 助理研究员，中山大学附属第一医院肾内科
2010.07—2013.01 医师，中山大学附属第一医院肾内科
2005.09-2010.06 博士，中山大学附属第一医院肾内科
2000.09-2005.06 学士，华中科技大学同济医学院，临床医学

学术及社会任职
中华医学会肾脏病分会青年委员会委员

主要从事肾脏临床和基础研究工作，重点探讨免疫损伤在自身免疫性疾病、代谢性疾病和肾脏纤维化中的作用及调控机制。近年来，在医学领域的主流学术杂志共发表SCI论著18篇，其中第一作者/（共同）通讯作者论著9篇，包括Cell Metab, J Immunol, J Am Soc Nephrol, iScience等。先后获得国家自然科学基金青年基金、面上项目、广东省自然科学杰出青年基金、广东省特支计划青年拔尖人才、高校青年教师重点培育项目和中山大学柯麟新锐人才计划等资助。入选中国科协“未来女科学家计划”（2016）。

发表论文

Wang Y, Lu M, Xiong L, Fan J, Zhou Y, Li H, Peng X, Zhong Z, Wang Y, Huang F, Chen W, Yu X, Mao H. Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis. Cell Death Dis 2020 Jan 16;11(1):29
Zhang X*, Zhou Y*, Yu X, Huang Q, Fang W, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP. Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis. iScience 2019 Aug 9;19:607-622 (co-first author)
Peng X, Wang Y, Li H, Fan J, Shen J, Yu X, Zhou Y, Mao H. ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury. Cell Death Dis 2019 Mar 15;10(4):253 (co-correspondence author)
Cao S, Li S, Wang Y, Shen J, Zhou Y, Li H, Yu X, Mao H. Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis. BioMed Res Int 2018 Nov 12;2018:2649585
Zhou Y, Chen H, Yang M, Zhang L, Ichimura T, Liu L, Yu X, Sukhova GK, Kyttaris VC, Bonventre JV, Tsokos GC, Libby P, Stillman IE, Shi GP. CD74 Deﬁciency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol 2017;198(7):2568-2577
Zhou Y, Chen H, Liu L, Yu XQ, Sukhova GK, Yang M, Kyttaris V, Stillman I, Libby P, Tsokos G, Shi GP. Cathepsin K deficiency suppresses autoimmunity and nephritis by inhibiting Toll-like receptor-7 activation and enhancing regulatory T cell function. J Immunol 2017;198(5):1846-1854
Zhou Y, Cao S, Li H, Peng X, Wang Y, Fan J, Wang Y, Zhuang S, Yu X, Mao H. Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis. Am J Pathol 2016;186(4):816-828
Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol 2016;36(1):69-77
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP*. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med 2015;21(7):820-826
Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab 2015;22(6):1045-1058
Zhou Y, Wu W, Lindholt JS, Sukhova GK, Libby P, Yu X, Shi GP. Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms. Cardiovasc Res 2015;107(1):98-107
Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH. The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Infect Immun 2014;82(6):2553-2564
Cao S, Li S, Li H, Xiong L, Zhou Y, Fan J, Yu X, Mao H. The potential role of HMGB1 release in peritoneal dialysis-related peritonitis. PLoS One 2013;8(1):e54647
Cao X, Yang Q, Qin J, Zhao S, Li X, Fan J, Chen W, Zhou Y, Mao H, Yu X. V-ATPase promotes transforming growth factor-β-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells. Am J Physiol Renal Physiol 2012;302(9):F1121-1132
Li S*, Zhou Y*, Fan J, Cao S, Cao T, Huang F, Zhuang S, Wang Y, Yu X, Mao H. Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. Am J Pathol 2011;179(6):2822-2834 (co-first author)
Zhou Y, Mao H, Li S, Cao S, Li Z, Zhuang S, Fan J, Dong X, Borkan SC, Wang Y, Yu X. Hsp72 Inhibits Smad3 Activation and Nuclear Translocation in Renal Epithelial-to-Mesenchymal Transition. J Am Soc Nephrol 2010;21:598–609

朱进霞

生理学教授，博士生导师。2004年获香港中文大学生理学博士学位，1996-1999年赴美国密西根大学医学院胃肠科—脑肠肽研究所深造，在Am J Physiol, J Physiol-London, Gastroenterology, Lancet和Br J Pharmacol等国际专业杂志发表学术论文60余篇。2004年作为北京市特聘教授、生理学学科带头人引进首都医科大学并建立了消化生理与病理研究室。现任中国生理学会理事、中国生理学会消化与营养专业委员会候任主委、中国生理学会内分泌代谢专业委员会副主委、中国中医药研究促进会消化整合医学分会执行理事等。主要从事脑-肠胺（5-HT, DA, NE）、脑-肠轴与胃-肠-胰腺的功能与功能紊乱、消化道跨上皮细胞离子转运、以及祖国医学与胃肠功能调节等领域的基础以应用基础研究。2006年获北京市高校拔尖创新人才，2010年获北京市高校胃肠动力研究创新团队。近10年先后承担包括科技部重点专项子课题、国家自然科学基金和北京市自然科学（重点）基金二十余项。近5年以第一作者和责任作者在国际专业学术杂志上发表SCI收录的研究论文22篇，主编2部、副主编3部生理学教材。

发表论文

Xiu XL, Zheng LF, Liu XY, Fan YY, Zhu JX*. Gastric smooth muscle cells manifest an abnormal phenotype in Parkinson's disease rats with gastric dysmotility. Cell Tissue Res 2020 Aug;381(2):217-227
Zheng LF, Ji T, Guo ZH, Wang T, Xiu XL, Liu XY, Li SC, Sun L, Xue H, Zhang Y, Zhu JX*. Na+-K+-2Cl- cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice. Eur J Pharmacol 2020 Aug 5;880:173162
Zhou Li, Ran XR, Hong F, Li GW. Zhu JX*. Downregulated dopamine receptor 2 and upregulated corticotrophin releasing hormone in the paraventricular nucleus are correlated with decreased glucose tolerance in rats with bilateral substantia nigra lesions. Front Neurosci 2019 Jul 23;13:751
Li Y, Zhang XL, Zhang Y, Feng XY, Liu CZ, Zhang XN, Zhu JX*. Dopamine Promotes Colonic Mucus Secretion through Dopamine D5 Receptor in Rats. AJP-Cell Physiology 2019 Mar 1;316(3):C393-C403
Liu CZ, Zhang XL, Zhou L, Wang T, Quan ZS, Zhang Y, Li J, Li GW, Zheng LF, Li LS, Zhu JX*. Rasagiline, an inhibitor of MAO-B, decreases colonic motility through elevating colonic dopamine content. Neurogastroenterol Motil 2018 Nov;30(11):e13390
Feng XY, Zhang DN, Wang YA, Fan RF, Hong F, Zhang Y, Li Y*, Zhu JX*. Dopamine enhances duodenal epithelial permeability via the dopamine D5 receptor in rodent. ACTA Physiologica (Oxf). 2017 May;220(1):113-123
Zhang XL, Li Y, Liu CZ, Fan RF, Wang P, Zheng LF, Hong F, Feng XY, Zhang Y, Li LS, Zhu JX*. Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-OHDA-induced Parkinson’s disease rats. Transl Res 2015;166:152-162
Y Chen, F Hong(Co-first author), H Chen, RF Fan, XL Zhang, Y Zhang, JX Zhu*. Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Cell Tissue Res 2014 Sep;357(3):597-606
J Song, LF Zheng, XL Zhang, XY Feng, RF Fan, L Sun, Y Zhang, JX Zhu*. Upregulation of β1-adrenoceptors is involved in the formation of gastric dysmotility in the 6-OHDA rat model of Parkinson's disease. Transl Res 2014;164:22–31
Hong F, Liu L, Fan RF, Chen Y, Chen H, Zheng RP, Zhang Y, Jing P, GaoY, Zhu JX*. New Perspectives of VMAT2 Chemical Characteristics in Mammals and Its Constant Expression in Type1 Diabetes Rat Models. Transl Res 2014 Feb;163(2):171-182
Zheng LF, Song J, Fan RF, Chen CL, Zhang XL, Feng XY, Zhang Y, Li LS, Zhu JX*. The role of vagal pathway and gastric dopamine in the gastroparesis of rats after 6-hydroxydopamine microinjection in the substantia nigra. ACTA Physiol (Oxf) 2014 June;211(2):434–446
Cited in
RF Pfeiffer*. Gastrointestinal involvement in Parkinson’s disease: the horse or the cart (Editorial). Acta Physiol (Oxf) 2014 Jun;211(2):271-272
(This model has been written in “Critical Evaluation of Animal Models of Gastrointestinal Disorders” Chapter in Handb Exp Pharmacol 2017;239:289-317)
Ye Chen, Feng Hong(Co-first author), Hui Chen, Ruifang Fan, Xiaoli Zhang, Yue Zhang, Zhu JX*. Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Cell Tissue Res 2014 Sep;357(3):597-606
Feng XY, Li Y, Li LS, Li XF, Zheng LF, Zhang XL, Fan RF, Song J, Hong F, Zhang Y, Zhu JX*. Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats. Transl Res 2013;161(6):486-494
Xu JD, Liu S(Co-first author), Wang W, Li LS, Li XF, Li Y, Guo H, Ji T, Feng XY, Hou XL, Zhang Y, Z Zhu JX*. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br J Pharmacol 2012;165:197–207
Ji T, Liu SM, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX*. Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock. Cell Tissue Res 2012;348(1):155-165
Yang N, SM Liu, LF Zheng, T Ji, Y Li, XL Mi, H Xue, W Ren, JD Xu, XH Zhang, LS Li, Y Zhang, Zhu JX. Activation of Submucosal 5-HT3 Receptor Elicits a Somatostatin- dependent Inhibition of Rat Colonic Secretion. Br J Pharmacol 2010;159:1623-1635

朱景宁

南京大学，生命科学学院，教授

学习和工作经历
2019/07–至今：南京大学，生命科学学院，副院长
2018/03–2019/07：南京大学，生命科学学院，生理学系系主任
2012/12–至今：南京大学，生命科学学院，教授
2007/12–2012/12：南京大学，生命科学学院，副教授
2006/08–2007/12：南京大学，生命科学学院，讲师
2001/09–2006/06：南京大学，生理学，博士
1997/09–2001/06，南京师范大学，生物科学（国家理科基地），学士

奖励和荣誉
2010：International Brain Research Organization (IBRO) Alumni Committee Award（国际脑研究组织校友委员会奖，全球同年共3人获此奖项）
2007：江苏省优秀博士学位论文
2006：中国生理学会张锡钧基金会第九届全国优秀生理学论文奖三等奖

学术及社会任职
2019-至今：生理学报，常务编委
2014-2019：生理学报，编委
2013-至今：Cerebellum & Ataxias，编委
2018-至今：中国生理学会，常务理事
2019-至今：中国生理学会，青年工作委员会副主任委员
2010-至今：中国生理学会，比较生理学专业委员会委员
2015-至今：中国神经科学学会，理事
2016-至今：中国神经科学学会，感觉和运动分会副主任委员
2016-至今：中国神经科学学会，青年工作委员会委员
2015-至今：全国科学技术名词审定委员会，第二届生理学名词审定委员会委员
2019-至今：江苏省生理科学学会，理事长
2016-至今：江苏省神经科学学会，常务理事
2017-至今：Society for Research on the Cerebellum and Ataxias, International Delegate

发表论文

Ji MJ, Zhang XY, Chen Z, Wang JJ*, Zhu JN*. (2019) Orexin prevents depressive-like behavior by promoting stress resilience. Molecular Psychiatry 24(2):282-293
Image: Ji MJ, Zhang XY, Chen Z, Wang JJ*, Zhu JN*. (2019) Two orexin receptors, OX1R and OX2R, are expressed and co-localized in the ventral pallidal neurons. Molecular Psychiatry 24:161
Chen ZP, Zhang XY, Peng SY, Yang ZQ, Wang YB, Zhang YX, Chen X, Wang JJ*, Zhu JN*. (2019) Histamine H1 receptor contributes to vestibular compensation. Journal of Neuroscience 39(3):420-433
Zhuang QX, Li GY, Li B, Zhang CZ, Zhang XY, Xi K, Li HZ, Wang JJ*, Zhu JN*. (2018) Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits. Journal of Clinical Investigation 128(12):5413-5427
Commentary by Whalen TC, Gittis AH. (2018) Histamine and deep brain stimulation: the pharmacology of regularizing a brain. Journal of Clinical Investigation 128(12):5201-5202
JCI Research Editor’s Picks: Normalizing subthalamic nucleus neuronal firing pattern improves parkinsonian motor impairment. JCI This Month 2018, 12:2
Wang Y, Chen ZP, Zhuang QX, Zhang XY, Li HZ, Wang JJ*, Zhu JN*. (2017) Role of corticotropin-releasing factor in cerebellar motor control and ataxia. Current Biology 27(17):2661-2669
Dispatched by Manto M. (2017) Motor control: CRF regulates coordination and gait. Current Biology 27(17):R847-R850
Zhang J, Li B, Yu L, He YC, Li HZ, Zhu JN*, Wang JJ*. (2011) A role for orexin in central vestibular motor control. Neuron 69(4):793-804
Previewed by Gao XB, Horvath TL. (2011) An arousing discovery on catalepsy: orexin regulates vestibular motor functions. Neuron 69(4):588-590

发表综述

李光英, 庄乾兴, 李斌, 王建军*, 朱景宁*.（2017）底丘脑核：从环路、功能到深部脑刺激治疗帕金森病的靶点. 生理学报 69(5):611-622
Zhang XY, Wang JJ*, Zhu JN*. (2016) Cerebellar fastigial nucleus: from anatomic construction to physiological functions. Cerebellum Ataxias 3:9
Li B, Zhu JN*, Wang JJ. (2014) Histaminergic afferent system in the cerebellum: structure and function. Cerebellum Ataxias 1:5
He YY, Zhang XY, Yung WH, Zhu JN*, Wang JJ*. (2013) Role of BDNF in central motor structures and motor diseases. Molecular Neurobiology 48(3):783-793
Zhang XY, Yu L, Zhuang QX, Zhu JN*, Wang JJ*. (2013) Central functions of the orexinergic system. Neuroscience Bulletin 29(3):355-365 (Cover Story)

发表专著

朱景宁, 王建军. （2014）躯体运动与非躯体反应协调整合的中枢机制. 王建军, 王晓民（主编）. 生理科学进展. 高等教育出版社. 北京. pp. 684-694
王建军, 朱景宁. （2013）躯体运动及其中枢控制. 寿天德（主编）. 神经生物学（第3版）. 高等教育出版社. 北京. pp. 245-300

邹明辉

现任佐治亚州立大学科研事务协管副校长，分子和转化医学中心主任、医学终身教授和化学与分子生物学终身教授。邹明辉是美国佐治亚“杰出学者”研究院（Academy of the Eminent Scholars, Georgia research Alliance）院士。于2008年遴选为美国临床医学研究协会（American Society for Clinical Investigation, 美国最悠久和最有声望的医生—科学家组织) 会员。自2005-2015, 邹明辉曾任俄克拉荷马大学院医学终身教授和生物化学与分子生物学终身教授，俄克拉荷马大学医学院分子医学系主任，俄克拉荷马大学院医学系副主任，兼任俄克拉荷马大学医学院Travis Endowed Chair内分泌讲座教授和Warren Endowed Chair糖尿病讲座教授。

邹明辉教授曾荣获美国心脏学会国内科学家发展计划奖（Science Development Award of AHA）、美国心脏学会国内科学家独立研究奖（National Established Investigator Award of AHA）、国际青少年糖尿病基金会独立研究奖、美国心脏学会Irivne H. Page动脉粥样硬化研究奖、Robert F. Furchgott研究奖、美国俄克拉荷马大学董事会研究与发明董事会奖（2011）、俄克拉荷马大学George Lynn Cross研究终身教授（俄克拉荷马大学最高声望教授, 2012）等。

邹明辉教授的研究得到美国国立卫生研究院（NIH）、美国糖尿病协会（ADA）和美国心脏病协会（AHA）等基金的重点资助。邹明辉教授共承担美国国立卫生研究院（NIH）及其它课题20多项，经费总计达6300万美元。邹明辉教授目前以项目负责人的身份主持包括11项美国NIH RO1基金在内的十余项研究基金。邹明辉教授在国际著名杂志Nature Medicine, Stem Cell, Molecular Cell, Journal of Clinical Investigation, Journal of Experimental Medicine, Circulation, Circulation Research, Diabetes等国际学术期刊发表SIC学术论文180余篇，其中影响因子>6.0的论文90多篇。编写学术专著7部。邹明辉教授还任《Diabetes, Metabolic Syndrome and Obesity》主编、《Journal of Molecular and Cellular Cardiology》《Frontiers in cardiovascular Metabolism》付主编杂志及多项国际权威杂志的编委，如Journal of Clinical Investigation, Circulation, Circulation Research, ATVB, Cardio-renal Medicine等国际学术期刊。

邹明辉教授主要研究方向是代谢性心血管疾病。邹明辉教授带领的科研团队针对代谢性心血管病的致病因素进行了大量的基础和临床转化研究, 长期聚焦于腹主动脉瘤、动脉粥样硬化、高血压、糖尿病、吸烟、肥胖和血管老化等心血管代谢疾病领域。在这些研究中，邹明辉教授的科研团队不但在世界范围内系统阐明了多种传统危险因素(糖尿病、吸烟、肥胖、血管老化等)在代谢性心血管病发生发展的病理生理机制，为代谢性心血管病研究提供了明确的病理基础，而且还率先揭示了多种新的致病因素、新的病理变化、新的代谢标记物及新的药物干预靶点在代谢性心血管疾病发生发展中的作用，为代谢性心血管病诊治研究提出了新观点、新概念、新理论和新疗法，也为心血管代谢疾病的临床干预、靶标治疗和风险预测提供了新的理论基础。

发表论文

Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z, Zou MH. Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo. Circulation. 2019 Apr 16;139(16):1913-1936
Han Y, Bedarida T, Ding Y, Somba BK, Lu Q, Wang Q, Song P, Zou MH. β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Mol Cell. 2018 Sep 20;71(6):1064-1078
Liu Z, Zhu H, Dai X, Wang C, Ding Y, Song P, Zou MH. Macrophage liver kinase B1 inhibits foam cell formation and atherosclerosis. Circ Res. 2017 Oct 13;121(9):1047-1057
Wang X, Wu W, Zhang W, Leland Booth J, Duggan ES, Tian L, More S, Zhao YD, Sawh RN, Liu L, Zou MH, Metcalf JP. RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir Res. 2017 Sep 2;18(1):166
Wu S, Lu Q, Wang Q, Ding Y, Ma Z, Mao X, Huang K, Xie Z, Zou MH. Binding of FUNDC1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum (ER) membranes maintains mitochondrial dynamics and function in hearts in vivo. Circulation. 2017 Dec 5;136(23):2248-2266
Wang Q, Ding Y, Song P, Zhu H, Okon I, Ding NY, Chen H, Liu D, Zou MH. Tryptophan-derived 3-hydroxyanthranilic acid contributes to angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. Circulation. 2017 Dec 5;136(23):2271-2283
Cai Z, Ding Y, Zhang M, Lu Q, Wu S, Zhu H, Song P, Zou MH. Ablation of Adenosine Monophosphate-activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification in vivo. Circ Res. 2016 Jul 22;119(3):422-433
Ding Y, Zhang M, Zhang W, Lu Q, Cai Z, Song P, Okon IS, Xiao L, Zou MH. AMP-activated protein kinase alpha 2 deletion induces VSMC phenotypic switching and promotes atherosclerotic plaque instability. Circ Res. 2016 Sep 2;119(6):718-730
Dai X, Ding Y, Liu Z, Zhang W, Zou MH. Phosphorylation of C/EBP Homologous Protein (CHOP) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res. 2016 Oct 28;119(10):1089-1100
Wu Y, Song P, Zhang W, Liu J, Dai X, Liu Z, Lu Q, Ouyang C, Xie Z, Zhao Z, Zhuo X, Viollet B, Foretz M, Wu J, Yuan ZY, Zou MH. Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat Med. 2015 Apr;21(4):373-382

ISSN 0371-0874, CN 31-1352/Q

创刊于1927年

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