当期文章

SIRT1在心力衰竭中作用的研究进展

张洋铭, 吕迈, 吴晨阳, 陈芫曦, 马国兰, 罗岸涛^*

武汉科技大学医学院，职业危害识别与控制湖北省重点实验室，心血管研究所，武汉 430065

摘要

心力衰竭(心衰)是各种心脏疾病的严重和终末阶段，在全球范围内给人们的健康带来了沉重的负担。由于其死亡率 高且长期预后不佳，目前迫切需要新的治疗方法。SIRT1 是一种烟酰胺腺嘌呤二核苷酸(NAD+)依赖性去乙酰化酶，有抗心 血管衰老特性以及其它心脏保护作用，近年来备受关注。此外，SIRT1 在心衰的病理生理学过程中发挥着重要作用。本综述 总结了SIRT1 及其激动剂在心衰中的作用，动物模型和心衰患者心脏组织中SIRT1 基因表达水平的变化，以及将SIRT1 激动 剂作为心衰潜在治疗方法的临床试验现状。这将为进一步探究心衰的病理机制以及制定临床预防策略提供新思路。

关键词： SIRT1; 心力衰竭; SIRT1激动剂; 心功能; 基因表达

Research progress on the role of SIRT1 in heart failure

ZHANG Yang-Min, LYU Mai, WU Chen-Yang, CHEN Yuan-Xi, MA Guo-Lan, LUO An-Tao^*

Institute of Cardiovascular Diseases, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract

Heart failure (HF) is a common end-stage clinical manifestation of cardiovascular diseases, imposing substantial healthrelatedburdens worldwide. With its high mortality rates and poor long-term prognosis, there is a pressing need for novel therapies.SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, has anti-cardiovascular aging properties and other cardioprotectiveeffects, attracting much research attention in recent years. In addition, SIRT1 plays an important role in HF pathophysiology.This review summarized the roles of SIRT1 and its activators in HF, the changes of SIRT1 gene expression in cardiac tissuesfrom animal models and HF patients, and the current status of clinical trials investigating SIRT1 activators as potential therapies forHF. This will provide new ideas for further exploration of pathological mechanisms and the development of clinical prevention strategiesfor HF.

Key words: SIRT1; heart failure; SIRT1 activator; cardiac function; gene expression

收稿日期：　　录用日期：

通讯作者：罗岸涛　　E-mail:

DOI: 10.13294/j.aps.2025.0030

引用本文：

张洋铭, 吕迈, 吴晨阳, 陈芫曦, 马国兰, 罗岸涛. SIRT1在心力衰竭中作用的研究进展[J]. 生理学报 2025; 77 (2): 361-373.

ZHANG Yang-Min, LYU Mai, WU Chen-Yang, CHEN Yuan-Xi, MA Guo-Lan, LUO An-Tao. Research progress on the role of SIRT1 in heart failure. Acta Physiol Sin 2025; 77 (2): 361-373 (in Chinese with English abstract).