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JAK/STAT信号通路在类风湿关节炎疼痛中的研究进展

刘振强¹, 尤浩军^1,2, 雷静^1,2,*

¹延安大学感觉与运动疾病转化医学研究中心，延安 716000；²延安市运动康复医学重点实验室，延安 716000

摘要

类风湿关节炎(rheumatoid arthritis, RA)是一种常见的以滑膜炎及骨破坏为特征的全身炎症性自身免疫性疾病，其临床特征主要为关节疼痛、肿胀、僵硬以及关节畸形。由于药物和非药物治疗效果不佳，RA患者生活质量显著受到影响，个人及社会经济负担加重。研究表明，Janus 激酶(Janus kinase, JAK)/信号转导和转录激活因子(signal transduction and activatorof transcription, STAT)作为经典的胞内信号，可调节炎症、免疫、细胞分化，在结缔组织疾病发生和发展中发挥重要作用。本文综述了JAK/STAT信号通路参与RA慢性疼痛机制的研究进展，以期为理解RA慢性疼痛发病机制并开展针对性的药物研发提供参考。

关键词： 类风湿关节炎; JAK/STAT信号通路; 慢性疼痛

Research progress of JAK/STAT signaling pathway in rheumatoid arthritis pain

LIU Zhen-Qiang¹, YOU Hao-Jun^1,2, LEI Jing^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan'an University, Yan'an 716000, China；²Laboratory of Yan'an Sports Rehabilitation Medicine, Yan'an 716000, China

Abstract

Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by synovitis and bone destruction. Its clinical characteristics are mainly joint pain, swelling, stiffness and joint deformity. Due to the poor efficacy of both drug and non-drug therapies, RA can significantly impact patients' quality of life and increase personal and socioeconomic burdens. Studies have found that the Janus kinase (JAK)/signal transduction and activator of transcription (STAT) pathway, as classical intracellular signaling pathway, plays an important role in the occurrence and development of connective tissue diseases by regulating inflammation, immunity, and cell differentiation. This article reviews the research progress on the involvement of JAK/STAT signaling pathway in the mechanism of RA pathological pain, in order to provide some reference for understanding the pathogenesis of RA pathological pain and developing specific drug.

Key words: rheumatoid arthritis; JAK/STAT pathway; chronic pain

收稿日期：　　录用日期：

通讯作者：雷静　　E-mail:

DOI: 10.13294/j.aps.2025.0014

引用本文：

刘振强, 尤浩军, 雷静. JAK/STAT信号通路在类风湿关节炎疼痛中的研究进展[J]. 生理学报 2025; 77 (1): 131-138.

LIU Zhen-Qiang, YOU Hao-Jun, LEI Jing. Research progress of JAK/STAT signaling pathway in rheumatoid arthritis pain. Acta Physiol Sin 2025; 77 (1): 131-138 (in Chinese with English abstract).