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TREK-1钾通道的结构与功能及其相关疾病的研究进展

李晓玲^1,2,3, 李扬^4,*, 张弘¹

¹沈阳药科大学生命科学与生物制药学院，沈阳 110016；²长三角药物高等研究院，南通 226133；³奥泽康(南通)医药科技有限公司，南通 226126；⁴中国科学院上海药物研究所，上海 201203

摘要

双孔钾离子通道(two-pore-domain potassium channels, K2P)家族在多种器官和细胞类型中广泛表达，并发挥重要的生理调节作用。K2P家族对多种化学和物理刺激非常敏感，与神经信号传递、离子稳态、细胞发育和死亡、突触可塑性等密切相关，其异常表达和功能障碍与一系列疾病相关，包括自身免疫性疾病、中枢神经系统疾病、心血管疾病等。本文就K2P家族中的TREK-1钾通道的结构、功能、调节剂，以及TREK-1与相关疾病作一综述。

关键词： 双孔钾离子通道; TREK-1; 功能调控; TREK-1相关疾病

Research advances on the structure, function, and related diseases of TREK-1 potassium channels

LI Xiao-Ling^1,2,3, LI Yang^4,*, ZHANG Hong¹

¹School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China；²Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China；³Aozekang (Nantong) Medical Technology Co., Nantong 226126, China；⁴Shanghai Institute of Pharmacy, Chinese Academy of Sciences, Shanghai 201203, China

Abstract

Two-pore-domain potassium channels (K2P) family is widely expressed in many human cell types and organs, which has important regulatory effect on physiological processes. K2P is sensitive to a variety of chemical and physical stimuli, and they have also been critically implicated in transmission of neural signal, ion homeostasis, cell development and death, and synaptic plasticity. Aberrant expression and dysfunction of K2P channels are involved in a range of diseases, including autoimmune, central nervous system, cardiovascular disease and others. The scope of this review is to give a detailed overview of the structure, function, pharmacological regulation, and related diseases of TREK-1 channels, a member of the K2P family.

Key words: two-pore-domain potassium channels; TREK-1; functional regulation; TREK-1-related diseases

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通讯作者：李扬　　E-mail:

引用本文：

李晓玲, 李扬, 张弘. TREK-1钾通道的结构与功能及其相关疾病的研究进展[J]. 生理学报 2024; 76 (6): 1043-1055.

LI Xiao-Ling, LI Yang, ZHANG Hong. Research advances on the structure, function, and related diseases of TREK-1 potassium channels. Acta Physiol Sin 2024; 76 (6): 1043-1055 (in Chinese with English abstract).