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胎球蛋白B在雌性生殖系统中的研究进展

王肖¹, 吕红艳², 陈德权³, 常波⁴, 姚婷婷^1,*

¹沈阳体育学院运动健康学院，沈阳 110102；²辽宁师范大学体育学院，大连 116029；³闽南师范大学体育学院，漳州 363000；⁴珠海科技学院体育科学学院，珠海 519041

摘要

胎球蛋白B (fetuin-B, FETUB)是一种主要由肝脏合成并分泌的糖蛋白，在葡萄糖代谢、炎症反应、非酒精性脂肪肝病、心肌梗死和肿瘤等生理和病理过程中具有广泛而重要的作用。近年来，FETUB被证实参与了雌性的生殖过程。有研究显示，女性在怀孕和分娩期间血清FETUB水平显著升高；FETUB还会影响卵泡发育，并参与体内和体外受精过程，进而调控雌性生殖功能。此外，在多种女性生殖疾病，如多囊卵巢综合征、妊娠期糖尿病、妊娠期肝内胆汁淤积症中，同样发现FETUB表达异常。因此，我们通过梳理FETUB在雌性生殖中的相关研究报道，全面阐述了FETUB在雌性生殖系统中的生理和病理作用，以期为生殖系统疾病病理机制提供更多思路。

关键词： 雌性生殖; 胎球蛋白B; 多囊卵巢综合征; 妊娠期糖尿病

Research progress of fetuin-B in the female reproductive system

WANG Xiao¹, LYU Hong-Yan², CHEN De-Quan³, CHANG Bo⁴, YAO Ting-Ting^1,*

¹School of Exercise and Health, Shenyang Sport University, Shenyang 110102, China；²School of Physical Education, Liaoning Normal University, Dalian 116029, China；³School of Physical Education, Minnan Normal University, Zhangzhou 363000, China；⁴School of Sports Science, Zhuhai College of Science and Technology, Zhuhai 519041, China

Abstract

Fetuin-B (FETUB) is a glycoprotein mainly synthesized and secreted by the liver. It is involved in many physiological and pathological processes including glucose metabolism, inflammatory response, nonalcoholic fatty liver disease, myocardial infarction, tumor and so on. In recent years, FETUB has also been confirmed to play roles in the female reproductive system. FETUB may affect follicular development and play an important role in in vivo and in vitro fertilization. In addition, serum FETUB level is elevated significantly during pregnancy and labor. FETUB expression is changed in a variety of reproductive diseases (polycystic ovary syndrome, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy). In this review, we summarize FETUB related studies in female reproduction, and focus on the roles of FETUB in female reproductive physiology and pathology, in order to provide information for the pathogenesis of reproductive disorders.

Key words: female reproduction; fetuin-B; polycystic ovary syndrome; gestational diabetes mellitus

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通讯作者：姚婷婷　　E-mail:

引用本文：

王肖, 吕红艳, 陈德权, 常波, 姚婷婷. 胎球蛋白B在雌性生殖系统中的研究进展[J]. 生理学报 2024; 76 (6): 1019-1031.

WANG Xiao, LYU Hong-Yan, CHEN De-Quan, CHANG Bo, YAO Ting-Ting. Research progress of fetuin-B in the female reproductive system. Acta Physiol Sin 2024; 76 (6): 1019-1031 (in Chinese with English abstract).