当期文章

抑制性离子通道甘氨酸受体的研究进展

庞旭柯^1,2, 陈思^1,2, 马相贤^1,2, 许一诺³, 白伟杰⁴, 付崇雷^1,2, 邹桂昌^5,1,2,*

¹山东第一医科大学(山东省医学科学院)脑科学与类脑研究院，济南 250117；²山东脑科学与类脑研究院，济南 250117；³山东第一医科大学第一附属医院(山东省千佛山医院)神经内科，济南 250117；⁴山东第一医科大学第一附属医院(山东省千佛山医院)神经外科，济南 250117；⁵山东第一医科大学附属省立医院临床心理科，济南 250117

摘要

抑制性离子通道甘氨酸受体(glycine receptors, GlyRs)属于配体门控离子通道受体超家族的一员，在中枢神经系统中广泛分布。GlyRs 对维持视觉、听觉、感觉和运动功能至关重要，其结构或功能异常会导致各种严重的神经系统疾病。本文旨在对GlyRs的结构、功能及调控机制进行深入的综述和分析，并探讨其在各种中枢神经系统疾病中的作用，为开发特异性靶向GlyRs的新型药物提供理论参考。

关键词： 抑制性离子通道; 甘氨酸受体; 神经系统疾病

Advances in inhibitory ion channel glycine receptors

PANG Xu-Ke^1,2, CHEN Si^1,2, MA Xiang-Xian^1,2, XU Yi-Nuo³, BAI Wei-Jie⁴, FU Chong-Lei^1,2, ZOU Gui- Chang^5,1,2,*

¹Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China；²Shandong Institute of Brain Science and Brain-inspired Research, Jinan 250117, China；³Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China；⁴Department of Neurosurgery, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China；⁵Department of Clinical Psychology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250117, China

Abstract

Glycine receptors (GlyRs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. GlyRs are essential for maintaining visual, auditory, sensory and motor functions, and abnormalities in its structure and function can lead to various neurological disorders. This review aims to provide an extensive analysis of the structure, function and regulatory mechanisms of GlyRs, and evaluate its role in various central nervous system diseases. Ultimately, this review will provide theoretical support for the development of novel drugs specifically targeting GlyRs.

Key words: inhibitory ion channel; glycine receptor; nervous system diseases

收稿日期：　　录用日期：

通讯作者：邹桂昌　　E-mail:

引用本文：

庞旭柯, 陈思, 马相贤, 许一诺, 白伟杰, 付崇雷, 邹桂昌. 抑制性离子通道甘氨酸受体的研究进展[J]. 生理学报 2024; 76 (6): 908-916.

PANG Xu-Ke, CHEN Si, MA Xiang-Xian, XU Yi-Nuo, BAI Wei-Jie, FU Chong-Lei, ZOU Gui- Chang. Advances in inhibitory ion channel glycine receptors. Acta Physiol Sin 2024; 76 (6): 908-916 (in Chinese with English abstract).