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胆红素在肿瘤中的预后意义和治疗前景

符雯, 陈鑫, 许雯雯, 刘金保^*

广州医科大学基础医学院病理生理学教研室，广东省蛋白质修饰与降解重点实验室，广州 511436

摘要

肿瘤是全球范围内的重大健康问题，长期以来一直是医学界的治疗难题。鉴于其治疗困境，探索新型预防与治疗策略尤为紧迫。胆红素作为一种天然的内源性抗氧化剂，能够抑制体内自由基的产生，减轻氧化应激对机体的损害。近年来，胆红素在氧化应激介导的疾病以及代谢性疾病中的治疗作用逐渐受到广泛关注，显示出对多种疾病的潜在治疗价值。随着研究的深入，胆红素与肿瘤领域的研究也取得较大进展，其在肿瘤的发生、发展及治疗中可能发挥着重要作用。本文旨在对近年来胆红素在肿瘤领域的研究进展进行梳理和总结，以期为未来的肿瘤诊断、预防及治疗方向提供新的思路和指导。

关键词： 胆红素; 肿瘤诊断; 肿瘤治疗; 抗氧化; 纳米药物

The prognostic significance and therapeutic prospects of bilirubin in tumors

FU Wen, CHEN Xin, XU Wen-Wen, LIU Jin-Bao^*

Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Department of Pathophysiology, School of Basic Medicine, Guangzhou Medical University, Guangzhou 511436, China

Abstract

Tumors pose a significant global health concern and have long been a challenging issue in the medical field. Given its treatment dilemma, it is urgent to explore novel prevention and treatment strategies. Bilirubin, as a natural endogenous antioxidant, has the ability to inhibit the production of free radicals in the body, thereby alleviating the damage caused by oxidative stress to the organism. In recent years, the therapeutic effects of bilirubin in diseases mediated by oxidative stress and metabolic disorders have gradually gained widespread attention, demonstrating its potential therapeutic value for a variety of diseases. With further research, significant progress has also been made in the study of bilirubin in the field of oncology, suggesting its potential important role in the occurrence, development, and treatment of tumors. This article aims to review and summarize the recent advances in the study of bilirubin in the field of oncology, in order to provide new insights and guidance for the future directions of tumor diagnosis, prevention, and treatment.

Key words: bilirubin; tumor diagnosis; tumor treatment; antioxidation; nanomedicine

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通讯作者：刘金保　　E-mail:

引用本文：

符雯, 陈鑫, 许雯雯, 刘金保. 胆红素在肿瘤中的预后意义和治疗前景[J]. 生理学报 2024; 76 (5): 737-742.

FU Wen, CHEN Xin, XU Wen-Wen, LIU Jin-Bao. The prognostic significance and therapeutic prospects of bilirubin in tumors. Acta Physiol Sin 2024; 76 (5): 737-742 (in Chinese with English abstract).