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CDO1调控常见代谢性疾病的分子作用机制

刘奇, 沈文清^*

安徽师范大学体育学院生理生化检测与运动康复重点实验室，芜湖 241002

摘要

半胱氨酸双加氧酶1 (cysteine dioxygenase type 1, CDO1)属于半胱氨酸双加氧酶(cysteine dioxygenase, CDO)家族，是半胱氨酸分解代谢和牛磺酸合成代谢的关键酶，主要在肝脏、脂肪、胰腺、肾脏、肺、脑和小肠组织中高表达。CDO1参与多种常见代谢性疾病的病理生理学调控过程，例如脂代谢紊乱、胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病。本文梳理和总结近年CDO1调控常见代谢性疾病的分子作用机制研究进展，以期为靶向CDO1蛋白治疗胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病提供新的理论和实践依据。

关键词： CDO1; 半胱氨酸; 牛磺酸; 代谢性疾病

Molecular mechanism of CDO1 regulating common metabolic diseases

LIU Qi, SHEN Wen-Qing^*

Key Laboratory of Physiological and Biochemical Testing and Exercise Rehabilitation, School of Physical Education, Anhui Normal University, Wuhu 241002, China

Abstract

Cysteine dioxygenase type 1 (CDO1) belongs to the cysteine dioxygenase (CDO) family. CDO1 is the key enzyme in cysteine catabolism and taurine synthesis. CDO1 is highly expressed in liver, adipose tissue, pancreas, kidney, lung, brain and small intestine. CDO1 is involved in the pathophysiological regulation of various common metabolic diseases, such as lipid metabolism disorders, insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases. This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years, aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases.

Key words: CDO1; cysteine; taurine; metabolic diseases

收稿日期：　　录用日期：

通讯作者：沈文清　　E-mail:

DOI: 10.13294/j.aps.2024.0060

引用本文：

刘奇, 沈文清. CDO1调控常见代谢性疾病的分子作用机制[J]. 生理学报 2024; 76 (4): 576-586.

LIU Qi, SHEN Wen-Qing. Molecular mechanism of CDO1 regulating common metabolic diseases. Acta Physiol Sin 2024; 76 (4): 576-586 (in Chinese with English abstract).