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幽门螺杆菌感染诱导的癌症相关成纤维细胞对胃上皮-间质转化影响的研究进展

李逸粼¹, 郑丽飞^2,*

¹首都医科大学基础医学院，北京 100069；²首都医科大学基础医学院生理学与病理生理学系，北京 100069

摘要

幽门螺杆菌是一种能够在胃黏膜中定植的革兰氏阴性杆菌。幽门螺杆菌可诱导胃部产生癌症相关成纤维细胞。幽门螺杆菌的毒力因子以及癌症相关成纤维细胞可引发上皮-间质转化，导致局部炎症、胃黏膜损伤和慢性胃炎的发生。本文重点综述了幽门螺杆菌感染后癌症相关成纤维细胞介导的胃部上皮-间质转化的分子机制，为未来治疗幽门螺杆菌感染相关性胃癌的潜在分子靶点和策略提供新的见解。

关键词： 幽门螺杆菌; 癌症相关成纤维细胞; 上皮-间质转化; 转化生长因子β; PI3K-AKT

Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition

LI Yi-Lin¹, ZHENG Li-Fei^2,*

¹School of Basic Medical Sciences, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Abstract

Helicobacter pylori (Hp) is a Gram-negative bacterium that colonizes in the gastric mucosa. Hp induces the production of cancer-associated fibroblasts (CAF) in the stomach. The virulence factors of Hp and CAF trigger epithelial-mesenchymal transition (EMT), leading to local inflammation, damage to the gastric mucosa, and the occurrence of chronic gastritis. Here, we summarize the molecular mechanisms of CAF mediated gastric EMT after Hp infection, providing new insights into potential molecular targets and strategies for the future treatment of Hp infection associated gastric cancer.

Key words: Helicobacter pylori; cancer-associated fibroblasts; epithelial-mesenchymal transition; transforming growth factor β; PI3K-AKT

收稿日期：　　录用日期：

通讯作者：郑丽飞　　E-mail:

DOI: 10.13294/j.aps.2024.0056

引用本文：

李逸粼, 郑丽飞. 幽门螺杆菌感染诱导的癌症相关成纤维细胞对胃上皮-间质转化影响的研究进展[J]. 生理学报 2024; 76 (4): 547-560.

LI Yi-Lin, ZHENG Li-Fei. Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition. Acta Physiol Sin 2024; 76 (4): 547-560 (in Chinese with English abstract).