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八段锦可能通过调控Bmal1基因改善2型糖尿病患者的睡眠质量

董子萱, 马占科^*

宁夏师范大学体育学院，固原 756099

摘要

糖尿病的发病率不断上升，而糖尿病患者的睡眠质量通常会受到影响。八段锦可能通过调控Bmal1基因表达作用于机体生物节律、骨骼肌糖代谢、骨骼肌纤维以及视交叉上核(suprachiasmatic nucleus, SCN)脑区，对2型糖尿病(type 2 diabetes mellitus, T2DM)患者的血糖水平和昼夜节律进行调节，并改善T2DM患者的各项生理机能。本文综述八段锦对糖尿病患者Bmal1基因表达调控作用及机制，探讨八段锦通过调控Bmal1基因表达改善T2DM患者睡眠质量的可能性。本综述可为中国传统气功八段锦的临床应用提供新的领域，为糖尿病的运动疗法提供新的科学依据。

关键词： 八段锦; Bmal1; 糖尿病; 睡眠质量

Baduanjin improves sleep quality in patients with type 2 diabetes possibly via regulating Bmal1 gene

DONG Zi-Xuan, MA Zhan-Ke^*

Institute of Physical Education, Ningxia Normal University, Guyuan 756099, China

Abstract

The incidence of diabetes mellitus is increasing, and the sleep quality of patients with diabetes mellitus is often affected. Baduanjin may act on biological rhythm of the body, skeletal muscle glucose metabolism, skeletal muscle fibers and suprachiasmatic nucleus (SCN) by regulating the expression of Bmal1 gene, thus regulating the blood glucose level and circadian rhythm of patients with type 2 diabetes mellitus (T2DM) and improving their physiological functions. This article reviews the regulatory effect and mechanism of Baduanjin on Bmal1 gene expression in diabetes patients, and discusses the possibility of Baduanjin to improve the sleep quality of T2DM patients by regulating Bmal1 gene expression. This review can provide a new field for the clinical application of traditional Chinese Qigong Baduanjin, and provide a new scientific basis for exercise therapy of diabetes.

Key words: Baduanjin; Bmal1; diabetes mellitus; sleep quality

收稿日期：　　录用日期：

通讯作者：马占科　　E-mail:

DOI: 10.13294/j.aps.2024.0046

引用本文：

董子萱, 马占科. 八段锦可能通过调控Bmal1基因改善2型糖尿病患者的睡眠质量[J]. 生理学报 2024; 76 (3): 447-456.

DONG Zi-Xuan, MA Zhan-Ke. Baduanjin improves sleep quality in patients with type 2 diabetes possibly via regulating Bmal1 gene. Acta Physiol Sin 2024; 76 (3): 447-456 (in Chinese with English abstract).