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Chemerin在多囊卵巢综合征中的研究进展

朱晓娟¹, 邱杭¹, 刘圣兰¹, 戴伟¹, 胡海波^1,2, 黄浩^1,3,2,*

¹赣南医科大学药学院国家中药现代化工程技术研究中心-客家中医药资源研究分中心，赣州 341000；²比利时荷语鲁汶大学生物系，鲁汶 3000；³澳门科技大学中药质量研究国家重点实验室，澳门 999078

摘要

Chemerin作为一种多功能脂肪因子，通过内分泌和旁分泌起作用，它可以与已知的三个受体(ChemR23、GPR1和CCRL2)结合参与能量代谢、糖脂代谢和炎症等多种病理生理过程，尤其在代谢性疾病中发挥重要作用。多囊卵巢综合征(polycystic ovary syndrome, PCOS)是最常见的内分泌疾病之一，严重困扰育龄女性的正常生活。PCOS患者血清chemerin含量显著升高，且其卵巢中chemerin高表达。越来越多的研究表明chemerin通过影响肥胖症、胰岛素抵抗、高雄激素血症、氧化应激和炎症反应等参与PCOS的发生和发展过程。本文主要综述了chemerin蛋白的产生、亚型、功能和受体，从代谢、生殖、炎症等角度总结并探讨chemerin蛋白在PCOS中的研究现状，为PCOS的临床诊断和治疗提供理论基础和参考依据。

关键词： chemerin; 多囊卵巢综合征; 病理机制

Research progress of chemerin in polycystic ovary syndrome

ZHU Xiao-Juan¹, QIU Hang¹, LIU Sheng-Lan¹, DAI Wei¹, HU Hai-Bo^1,2, HUANG Hao^1,3,2,*

¹National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China；²Department of Biology, KU Leuven; Leuven 3000, Belgium；³State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China

Abstract

As a multifunctional adipokine, chemerin plays a crucial role in various pathophysiological processes through endocrine and paracrine manner. It can bind to three known receptors (ChemR23, GPR1 and CCRL2) and participate in energy metabolism, glucose and lipid metabolism, and inflammation, especially in metabolic diseases. Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases, which seriously affects the normal life of women of childbearing age. Patients with PCOS have significantly increased serum levels of chemerin and high expression of chemerin in their ovaries. More and more studies have shown that chemerin is involved in the occurrence and development of PCOS by affecting obesity, insulin resistance, hyperandrogenism, oxidative stress and inflammatory response. This article mainly reviews the production, subtypes, function and receptors of chemerin protein, summarizes and discusses the research status of chemerin protein in PCOS from the perspectives of metabolism, reproduction and inflammation, and provides theoretical basis and reference for the clinical diagnosis and treatment of PCOS.

Key words: chemerin; polycystic ovary syndrome; pathological mechanism

收稿日期：　　录用日期：

通讯作者：黄浩　　E-mail:

DOI: 10.13294/j.aps.2024.0001

引用本文：

朱晓娟, 邱杭, 刘圣兰, 戴伟, 胡海波, 黄浩. Chemerin在多囊卵巢综合征中的研究进展[J]. 生理学报 2024; 76 (3): 429-437.

ZHU Xiao-Juan, QIU Hang, LIU Sheng-Lan, DAI Wei, HU Hai-Bo, HUANG Hao. Research progress of chemerin in polycystic ovary syndrome. Acta Physiol Sin 2024; 76 (3): 429-437 (in Chinese with English abstract).