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过渡金属积累与细胞衰老

谢安娜, 刘国一, 张孙正远, 戴薇薇^*

上海中医药大学附属龙华医院科技中心实验室，上海 200032

摘要

衰老是指生物体的生理功能进行性衰退，导致年龄相关性疾病和死亡，细胞衰老是衰老标志之一。过渡金属包括铁、铜和锰等，在人体生理和病理过程中发挥重要作用。大量研究表明，衰老细胞中会积累更多过渡金属，而过渡金属积累又会通过产生过量活性氧(reactive oxygen species, ROS)、引发氧化应激、导致DNA损伤、引起线粒体功能障碍等方式加速细胞衰老进程并引起相关疾病。本文将对铁、铜、锰等过渡金属在衰老细胞中积累的原因以及过渡金属积累进一步促进细胞衰老及相关疾病的机制进行综述，旨在为延缓衰老、治疗过渡金属积累引起的衰老相关疾病提供思路。

关键词： 细胞衰老; 过渡金属积累; 活性氧; 氧化应激; 线粒体功能

Transition metal accumulation and cellular senescence

XIE An-Na, LIU Guo-Yi, ZHANG Sun-Zhengyuan, DAI Wei-Wei^*

Laboratory of Science and Technology Center, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Abstract

Aging refers to a progressive decline in biological functions, leading to age-related diseases and mortality. The transition metals, including iron, copper, and manganese, play important roles in human physiological and pathological processes. Substantial research has demonstrated that senescent cells accumulate higher levels of transition metals, which in turn accelerates the process of cellular senescence and related diseases through mechanisms such as production of excessive reactive oxygen species (ROS), induction of oxidative stress, DNA damage, and mitochondrial dysfunction. This review article provides a comprehensive overview of the causes of transition metal accumulation in senescent cells, as well as the mechanisms by which it further promotes cellular senescence and related diseases. The aim is to provide insights into anti-aging and treatment of aging-related diseases caused by transition metal accumulation.

Key words: Cellular senescence; transition metal accumulation; reactive oxygen species; oxidative stress; mitochondrial function

收稿日期：　　录用日期：

通讯作者：戴薇薇　　E-mail:

DOI: 10.13294/j.aps.2024.0032

引用本文：

谢安娜, 刘国一, 张孙正远, 戴薇薇. 过渡金属积累与细胞衰老[J]. 生理学报 2024; 76 (3): 418-428.

XIE An-Na, LIU Guo-Yi, ZHANG Sun-Zhengyuan, DAI Wei-Wei. Transition metal accumulation and cellular senescence. Acta Physiol Sin 2024; 76 (3): 418-428 (in Chinese with English abstract).