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PD-L1在肺部炎症性疾病中的研究进展

黎阿果^1,2, 蔡爱华^1,2, 李浩甲^1,3, 黄绮颖^1,2, 涂永生^1,4,*

¹广州医科大学广东省蛋白质修饰与降解重点实验室，广州 511436；²广州医科大学第二临床学院，广州 511436；³广州医科大学第三临床学院，广州 511436；⁴广州医科大学基础医学院生理学教研室，广州 511436

摘要

程序性死亡配体1 (programmed death-ligand 1, PD-L1)在维持正常组织中枢和外周免疫耐受、介导肿瘤免疫逃逸以及维持抗炎和促炎反应平衡方面具有重要意义。炎症反应在肺部炎症性疾病中发挥了重要作用。本文综述了PD-L1在急性肺损伤、慢性阻塞性肺疾病、哮喘、特发性肺纤维化等肺部炎症性疾病中的研究进展和潜在的临床价值。

关键词： 程序性死亡配体1; 急性肺损伤; 慢性阻塞性肺疾病; 哮喘; 特发性肺纤维化

Research progress of PD-L1 in inflammatory lung diseases

LI A-Guo^1,2, CAI Ai-Hua^1,2, LI Hao-Ji^1,3, HUANG Qi-Yin^1,2, TU Yong-Sheng^1,4,*

¹Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou 511436, China；²The Second Clinical College, Guangzhou Medical University, Guangzhou 511436, China；³The Third Clinical College, Guangzhou Medical University, Guangzhou 511436, China；⁴Department of Physiology, College of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China

Abstract

Programmed death-ligand 1 (PD-L1) is important in maintaining central and peripheral immune tolerance in normal tissues, mediating tumor immune escape and keeping the balance between anti- and pro-inflammatory responses. Inflammation plays an important role in inflammatory lung diseases. This article reviews the research progress and potential clinical value of PD-L1 in inflammatory lung diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma and idiopathic pulmonary fibrosis.

Key words: programmed death-ligand 1; acute lung injury; chronic obstructive pulmonary disease; asthma; idiopathic pulmonary fibrosis

收稿日期：　　录用日期：

通讯作者：涂永生　　E-mail: tuys@gzhmu.edu.cn

DOI: 10.13294/j.aps.2024.0013

引用本文：

黎阿果, 蔡爱华, 李浩甲, 黄绮颖, 涂永生. PD-L1在肺部炎症性疾病中的研究进展[J]. 生理学报 2024; 76 (2): 346-352.

LI A-Guo, CAI Ai-Hua, LI Hao-Ji, HUANG Qi-Yin, TU Yong-Sheng. Research progress of PD-L1 in inflammatory lung diseases. Acta Physiol Sin 2024; 76 (2): 346-352 (in Chinese with English abstract).