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非编码RNA参与肝细胞癌糖酵解调控的研究进展

胡晓峰^1,2, 张青^1,2, 梁美铝^1,2, 周青鸟^1,2, 赵瑞强^1,2, 龚祖康³, 林文珍^1,2,*

¹广西医科大学基础医学院生物化学与分子生物学教研室，南宁 530021；²广西高校生物分子医学研究重点实验室，南宁 530021；³南宁市疾病预防控制中心，南宁 530021

摘要

肝癌是一种常见的消化系统肿瘤，肝细胞癌(hepatocellular carcinoma, HCC)作为一种较为常见的肝癌类型，其恶性程度高且在全球癌症相关死亡原因中排在前列。代谢重编程被认为是癌症发生和发展的一个重要标志，糖代谢是细胞产生能量的主要途径之一。糖酵解作为糖代谢的基础性反应在细胞的代谢中发挥着举足轻重的作用，因此糖酵解的调控对于肿瘤的增殖与演变有着重要意义。越来越多的非编码RNA (non-coding RNA, ncRNA)被证实在肿瘤的糖酵解调控中发挥重要作用。本文综述了ncRNA在HCC糖酵解调控中的作用及相关机制，同时对基于糖酵解调控相关机制的靶向治疗HCC的方法提出展望。

关键词： 肝细胞癌; 非编码RNA; 糖代谢重编程; 糖酵解调控

Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma

HU Xiao-Feng^1,2, ZHANG Qing^1,2, LIANG Mei-Lv^1,2, ZHOU Qing-Niao^1,2, ZHAO Rui-Qiang^1,2, GONG Zu-Kang³, LIN Wen-Zhen^1,2,*

¹Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning 530021, China；²Laboratory of Biological Molecular Medicine Research (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Nanning 530021, China；³Nanning Center for Disease Control and Prevention, Nanning 530021, China

Abstract

Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.

Key words: hepatocellular carcinoma; non-coding RNA; glucose metabolism reprogramming; glycolysis regulation

收稿日期：　　录用日期：

通讯作者：林文珍　　E-mail: linwenzhen@msn.com

DOI: 10.13294/j.aps.2024.0018

引用本文：

胡晓峰, 张青, 梁美铝, 周青鸟, 赵瑞强, 龚祖康, 林文珍. 非编码RNA参与肝细胞癌糖酵解调控的研究进展[J]. 生理学报 2024; 76 (2): 319-328.

HU Xiao-Feng, ZHANG Qing, LIANG Mei-Lv, ZHOU Qing-Niao, ZHAO Rui-Qiang, GONG Zu-Kang, LIN Wen-Zhen. Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma. Acta Physiol Sin 2024; 76 (2): 319-328 (in Chinese with English abstract).