过刊浏览

延迟性肌肉酸痛：神经营养因子机制及其研究进展

刘云霄¹, 雷静^1,2, 尤浩军^1,2,*

¹延安大学感觉与运动疾病转化医学研究中心，延安 716000；²延安市运动康复医学重点实验室，延安 716000

摘要

延迟性肌肉酸痛(delayed-onset muscle soreness, DOMS)是机体经历运动强度突然增加或不熟悉的运动后，在一段时间内所出现的肌肉酸痛现象。DOMS可影响运动员和健身人群的运动功能，降低竞技体育运动的成绩和体育锻炼成效。DOMS的典型症状是触压痛，可同时存在痛觉过敏，具体机制尚不完全明确。近年来诸多研究证实，神经生长因子(nerve growth factor, NGF)和胶质细胞源性神经营养因子(glial cell derived neurotrophic factor, GDNF)等神经营养因子参与DOMS的发生和维持。本文对NGF与GDNF参与DOMS的相关信号通路研究进展作一综述，以期厘清DOMS中触压痛和痛觉过敏的产生机制，并为相关治疗提供新的思路。

关键词： 延迟性肌肉酸痛; 神经生长因子; 胶质细胞源性神经营养因子; 触压痛; 痛觉过敏

Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective

LIU Yun-Xiao¹, LEI Jing^1,2, YOU Hao-Jun^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan’an University, Yan’an 716000, China；²Key Laboratory of Yan’an Sports Rehabilitation Medicine, Yan’an 716000, China

Abstract

Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is characterized by allodynia and hyperalgesia, and their mechanisms remain unclear. Recent studies have reported that neurotrophic factors, such as nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF), are involved in the development and maintenance of DOMS. This article provides a review of the research progress on the signaling pathways related to the involvement of NGF and GDNF in DOMS, hoping to provide novel insights into the mechanisms underlying allodynia and hyperalgesia in DOMS, as well as potential targeted treatment.

Key words: delayed-onset muscle soreness; nerve growth factor; glial cell derived neurotrophic factor; allodynia; hyperalgesia

收稿日期：　　录用日期：

通讯作者：尤浩军　　E-mail: haojunyou@126.com

DOI: 10.13294/j.aps.2024.0017

引用本文：

刘云霄, 雷静, 尤浩军. 延迟性肌肉酸痛：神经营养因子机制及其研究进展[J]. 生理学报 2024; 76 (2): 301-308.

LIU Yun-Xiao, LEI Jing, YOU Hao-Jun. Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective. Acta Physiol Sin 2024; 76 (2): 301-308 (in Chinese with English abstract).