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哺乳动物心肌细胞再生专家共识

中国生理学会整合生理学专业委员会¹, 老年心脑血管病教育部重点实验室¹, 曾春雨², 杨黄恬³, 管又飞^4,*

¹；²第三军医大学大坪医院；³中国科学院上海营养与健康研究所；⁴大连医科大学

摘要

心肌梗死引起的大量心肌细胞损失导致心脏病理性重构和心力衰竭的发生，如何促进心肌再生是修复受损心脏的关键问题。心肌细胞再生主要源于原有心肌细胞的增殖已被广泛认同。近年来，该领域的快速发展加深了我们对心肌细胞再生的内源性细胞和微环境特征、外源性影响因素、分子生物学机制以及干预策略等各方面的认识。因此，我们对哺乳动物心肌细胞再生的定义、特征、评价和研究方法、调控机制以及干预措施等进行整理并形成共识，旨在明确该领域尚需进一步阐明的重要问题，推动心肌再生研究的深化及其在临床上的应用转化。

关键词： 心肌梗死; 心力衰竭; 心脏重塑; 心肌再生; 心肌细胞增殖

Experts’ consensus on mammalian cardiomyocyte regeneration

Chinese Society of Integrative Physiology, Chinese Association for Physiological Sciences¹, Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China¹, ZENG Chun-Yu², YANG Huang-Tian³, GUAN You-Fei^4,*

¹；²Department of Cardiology, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China；³Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China；⁴Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China

Abstract

Myocardial infarction (MI) leads to a massive loss of cardiomyocytes, resulting in pathological cardiac remodeling and heart failure. Promoting cardiomyocyte regeneration is crucial for repairing the damaged heart. It is acknowledged that regenerative cardiomyocyte derives from the existing cardiomyocytes. In recent years, advancements in this field have updated our understanding of cardiomyocyte regeneration in many aspects, including intrinsic cell source and microenvironmental characteristics, extrinsic factors, molecular biology mechanisms, and intervention strategies. Here, we report a consensus by an expert committee on the definition, characteristics, evaluation, research methods, regulatory mechanisms, and intervention measures related to mammalian cardiomyocyte regeneration. The aim is to clarify important unresolved issues in this field and to promote myocardial regeneration research and its clinical translation.

Key words: Myocardial infarction; heart failure; cardiac remodeling; cardiac regeneration; cardiomyocyte proliferation

收稿日期：　　录用日期：

通讯作者：管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2024.0015

引用本文：

中国生理学会整合生理学专业委员会, 老年心脑血管病教育部重点实验室, 曾春雨, 杨黄恬, 管又飞. 哺乳动物心肌细胞再生专家共识[J]. 生理学报 2024; 76 (2): 175-214.

Chinese Society of Integrative Physiology, Chinese Association for Physiological Sciences, Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China, ZENG Chun-Yu, YANG Huang-Tian, GUAN You-Fei. Experts’ consensus on mammalian cardiomyocyte regeneration. Acta Physiol Sin 2024; 76 (2): 175-214 (in Chinese with English abstract).