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线粒体相关内质网膜(MAMs)在衰老相关心血管疾病中的研究进展

张玉¹, 赵芯仪¹, 谢文俊², 张伊^1,*

¹西安交通大学医学部基础医学院生理学与病理生理学系，西安 710061；²西安交通大学第一附属医院心内科，西安 710061

摘要

线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membranes, MAMs)即线粒体和内质网之间的膜接触位点，是两个细胞器之间进行物质交换和信息交流的微区域，参与调控钙稳态、线粒体形态与功能、脂质代谢以及自噬等多种病理生理过程。近些年来，大量研究揭示了MAMs在心血管疾病中的作用。衰老是心血管疾病的主要独立危险因素之一，随着年龄增长，心血管系统的功能逐渐退化、发生功能障碍的风险持续增加。本文将重点阐述MAMs在衰老相关心血管疾病中的作用和机制，为心血管疾病的预防与治疗挖掘新靶点。

关键词： 线粒体相关内质网膜; 衰老相关心血管疾病; 钙稳态; 脂质代谢; 自噬

The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases

ZHANG Yu¹, ZHAO Xin-Yi¹, XIE Wen-Jun², ZHANG Yi^1,*

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China；²Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

Abstract

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are the physical connection sites between mitochondria and endoplasmic reticulum (ER). As the compartments controlling substance and information communications between ER and mitochondria, MAMs were involved in the regulation of various pathophysiological processes, such as calcium homeostasis, mitochondrial morphology and function, lipid metabolism and autophagy. In the past decades, accumulating lines of evidence have revealed the pivotal role of MAMs in diverse cardiovascular diseases (CVD). Aging is one of the major independent risk factors for CVD, which causes progressive degeneration of the cardiovascular system, leading to increased morbidity and mortality of CVD. This review aims to summarize the research progress of MAMs in age-related CVD, and explore new targets for its prevention and treatment.

Key words: mitochondrial-associated endoplasmic reticulum membranes (MAMs); age-related cardiovascular diseases; calcium homeostasis; lipid metabolism; autophagy

收稿日期：　　录用日期：

通讯作者：张伊　　E-mail: zhangyixjtu@xjtu.edu.cn

DOI: 10.13294/j.aps.2023.0081

引用本文：

张玉, 赵芯仪, 谢文俊, 张伊. 线粒体相关内质网膜(MAMs)在衰老相关心血管疾病中的研究进展[J]. 生理学报 2023; 75 (6): 799-816.

ZHANG Yu, ZHAO Xin-Yi, XIE Wen-Jun, ZHANG Yi. The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases. Acta Physiol Sin 2023; 75 (6): 799-816 (in Chinese with English abstract).