ISSN 0371-0874, CN 31-1352/Q



杨远青1, 靳灵燕2, 陈子溦3, 郑强荪2, 秦兴华1,*

1西北工业大学生命学院,西安 710072;2西安交通大学第二附属医院心血管内科,西安 710004;3西安医学院临床医学院呼吸病预防与诊治工程研究中心,西安 710021



关键词: 心房颤动; 衰老; 代谢紊乱; 代谢灵活性

Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly

YANG Yuan-Qing1, JIN Ling-Yan2, CHEN Zi-Wei3, ZHENG Qiang-Sun2, QIN Xing-Hua1,*

1School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China;2Department of Cardiovascular Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China;3Research Center for Prevention and Treatment of Respiratory Disease, School of Clinical Medicine, Xi’an Medical University, Xi’an 710021, China


Atrial fibrillation (AF) is a cardiovascular epidemic that occurs primarily in the elderly with primary cardiovascular diseases, leading to severe consequences such as stroke and heart failure. The heart is an energy-consuming organ, which requires a high degree of metabolic flexibility to ensure a quick switch of metabolic substrates to meet its energy needs in response to physiological and pathological stimulation. Metabolism is closely related to the occurrence of AF, and AF patients manifest metabolic inflexibility, such as insulin resistance and the metabolic shift from aerobic metabolism to anaerobic glycolysis. Moreover, our research group and the others have shown that metabolic inflexibility is a crucial pathologic mechanism for AF. Energy metabolism is closely linked to the aging process and aging-related diseases, and impaired metabolic flexibility is considered as an essential driver of aging. Therefore, this review focuses on the alteration of metabolic flexibility in the elderly and reveals that impaired metabolic flexibility may be an important driver for the high prevalence of AF in the elderly, hoping to provide intervention strategies for the prevention and treatment of AF in the elderly.

Key words: atrial fibrillation; aging; metabolic disorder; metabolic flexibility

收稿日期:  录用日期:

通讯作者:秦兴华  E-mail:

DOI: 10.13294/j.aps.2023.0088


杨远青, 靳灵燕, 陈子溦, 郑强荪, 秦兴华. 老年心房颤动的代谢机制及干预策略[J]. 生理学报 2023; 75 (6): 779-787.

YANG Yuan-Qing, JIN Ling-Yan, CHEN Zi-Wei, ZHENG Qiang-Sun, QIN Xing-Hua. Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly. Acta Physiol Sin 2023; 75 (6): 779-787 (in Chinese with English abstract).