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mRNA疫苗在人和动物重大疫病防控中的研究进展 

高嘉淇¹, 赵献军^1,2, 华进联^1,*

¹西北农林科技大学动物医学院，陕西省干细胞工程技术研究中心，杨凌 712100；²百欧派(天津)生物技术有限公司，天津 300350

摘要

已有大量研究证明mRNA疫苗具有安全性高、免疫效果好、开发潜力大等优点，在免疫治疗中是一种应用前景广阔的治疗策略。近年来，通过技术创新，mRNA疫苗的稳定性与体内递送效率大幅提高，目前一些mRNA疫苗已进入临床前试验。本文就mRNA疫苗的研究概况、技术以及在人和动物重大传染病中的应用三个方面对mRNA疫苗进展进行概述，以期为推进新型mRNA疫苗的研发提供参考。

关键词： mRNA疫苗; 传染病; 递送系统

Progress on mRNA vaccine for the prevention of major infectious diseases in humans and animals

GAO Jia-Qi¹, ZHAO Xian-Jun^1,2, HUA Jin-Lian^1,*

¹Shaanxi Stem Cell Engineering and Technology Research Center, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, China；²Baioupai (Tianjin) Biotechnology Co., Ltd., Tianjin 300350, China

Abstract

A large number of studies have demonstrated that mRNA vaccine has been characterized as a technique with good safety, strong immunogenicity and high developmental potential, which makes it have broad prospects in immunotherapy. In recent years, the stability and in vivo delivery efficiency of mRNA vaccines have been largely addressed by the progresses in mRNA engineering and delivery innovation. And some mRNA vaccines are now clinical approved or in preclinical trials. Here, we summarize current knowledge on the research advances, technology, and application in major infectious diseases in humans and animals of mRNA vaccines, with the aim to provide a reference for improving the development of novel mRNA vaccines.

Key words: mRNA vaccine; infectious diseases; delivery system

收稿日期：　　录用日期：

通讯作者：华进联　　E-mail: jinlianhua@nwsuaf.edu.cn

DOI: 10.13294/j.aps.2023.0058

引用本文：

高嘉淇, 赵献军, 华进联. mRNA疫苗在人和动物重大疫病防控中的研究进展 [J]. 生理学报 2023; 75 (5): 647-658.

GAO Jia-Qi, ZHAO Xian-Jun, HUA Jin-Lian. Progress on mRNA vaccine for the prevention of major infectious diseases in humans and animals. Acta Physiol Sin 2023; 75 (5): 647-658 (in Chinese with English abstract).