过刊浏览

脊髓以上水平疼痛相关神经通路机制的研究进展

陈栋洋, 韩庆荣, 盛海燕^*

新乡医学院基础医学院，新乡 453003

摘要

疼痛是一种多维度的情感体验，痛感觉和痛情绪是其最主要的两个组分。关于疼痛，以往研究只专注于痛觉传递通路的某个环节或某个关键脑区，缺乏行为个体脑区与脑区连接在整体状态下参与疼痛或调节疼痛的证据。新的实验工具和实验技术的诞生，为痛感觉和痛情绪的神经通路研究带来了曙光。本文综述了近年来脊髓水平以上的神经系统(包括丘脑、杏仁核、中脑导水管周围灰质、臂旁核和内侧前额叶皮层)参与形成痛感觉和调节痛情绪的神经通路结构和功能基础，为疼痛的深入研究提供线索。

关键词： 神经通路; 痛感觉; 痛情绪; 行为

Research progress on the mechanism of pain related neural pathways above the spinal cord

CHEN Dong-Yang, HAN Qing-Rong, SHENG Hai-Yan^*

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China

Abstract

Pain is a multi-dimensional emotional experience, and pain sensation and pain emotion are the two main components. As for pain, previous studies only focused on a certain link of the pain transmission pathway or a certain key brain region, and there is a lack of evidence that connectivity of brain regions is involved in pain or pain regulation in the overall state. The establishment of new experimental tools and techniques has brought light to the study of neural pathways of pain sensation and pain emotion. In this paper, the structure and functional basis of the neural pathways involved in the formation of pain sensation and the regulation of pain emotion in the nervous system above the spinal cord level, including thalamus, amygdala, midbrain periaqueductal gray (PAG), parabrachial nucleus (PB) and medial prefrontal cortex (mPFC), are reviewed in recent years, providing clues for the in-depth study of pain.

Key words: neural pathway; pain sensation; pain emotion; behavior

收稿日期：　　录用日期：

通讯作者：盛海燕　　E-mail: shenghy2011@126.com

引用本文：

陈栋洋, 韩庆荣, 盛海燕. 脊髓以上水平疼痛相关神经通路机制的研究进展[J]. 生理学报 2023; 75 (3): 475-485.

CHEN Dong-Yang, HAN Qing-Rong, SHENG Hai-Yan. Research progress on the mechanism of pain related neural pathways above the spinal cord. Acta Physiol Sin 2023; 75 (3): 475-485 (in Chinese with English abstract).