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生物钟紊乱防治策略的研究进展

彭景¹, 任保印¹, 张荷¹, 陈丽红², 杨光锐^1,*

¹大连理工大学生物工程学院，大连 116024；²大连医科大学医学科学研究院，大连 116044

摘要

生物钟是机体为适应环境周期性变化而进化出的一种内在机制。保持体内时钟与外界时钟步调一致对健康至关重要，二者不同步(比如作息不规律、时差、分子时钟机制被破坏等)可能导致生物钟紊乱，可表现为睡眠-觉醒周期异常，激素分泌、血压、心率、体温等节律或水平异常，长期紊乱还与代谢性疾病、心血管疾病、肿瘤等常见重大疾病密切相关。为解决长久以来生物钟紊乱无药可医的局面，科学家们在细胞和动物水平对生物钟基因的功能及其在疾病发生、发展中的作用进行了大量的研究，并对数十万计的小分子化合物进行筛选以探索药物调整生物钟的可行性。此外，褪黑素、光照疗法、运动疗法、调整摄食时间、改变食物营养成分等也对生物钟紊乱起到一定的缓解作用。本文将从药物干预和非药物干预两个角度对生物钟紊乱防治策略的研究进展进行综述。

关键词： 生物节律; 生物钟紊乱; 药物治疗; 非药物干预

Research progress in control strategies of biological clock disorder

PENG Jing¹, REN Bao-Yin¹, ZHANG He¹, CHEN Li-Hong², YANG Guang-Rui^1,*

¹School of Bioengineering, Dalian University of Technology, Dalian 116024, China；²Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Circadian clock is an internal mechanism evolved to adapt to cyclic environmental changes, especially diurnal changes. Keeping the internal clock in synchronization with the external clock is essential for health. Mismatch of the clocks due to phase shift or disruption of molecular clocks may lead to circadian disorders, including abnormal sleep-wake cycles, as well as disrupted rhythms in hormone secretion, blood pressure, heart rate, body temperature, etc. Long-term circadian disorders are risk factors for various common critical diseases such as metabolic diseases, cardiovascular diseases, and tumor. To prevent or treat the circadian disorders, scientists have conducted extensive research on the function of circadian clocks and their roles in the development of diseases, and screened hundreds of thousands of compounds to find candidates to regulate circadian rhythms. In addition, melatonin, light therapy, exercise therapy, timing and composition of food also play a certain role in relieving associated symptoms. Here, we summarized the progress of both drug- and non-drug-based approaches to prevent and treat circadian clock disorders.

Key words: biological rhythm; circadian disorder; drug therapy; non-drug intervention

收稿日期：　　录用日期：

通讯作者：杨光锐　　E-mail: guangrui.yang@hotmail.com

DOI: 10.13294/j.aps.2023.0021

引用本文：

彭景, 任保印, 张荷, 陈丽红, 杨光锐. 生物钟紊乱防治策略的研究进展[J]. 生理学报 2023; 75 (2): 279-290.

PENG Jing, REN Bao-Yin, ZHANG He, CHEN Li-Hong, YANG Guang-Rui. Research progress in control strategies of biological clock disorder. Acta Physiol Sin 2023; 75 (2): 279-290 (in Chinese with English abstract).