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成年内源性神经发生在脑损伤修复中的应用研究进展

白天宇¹, 穆娇¹, 郝鹏², 段红梅², 郝飞¹, 赵文², 高钰丹², 王子珏², 杨朝阳², 李晓光^1,2,*

¹北京航空航天大学生物与医学工程学院，生物材料与神经再生北京市重点实验室，北京 100083；²首都医科大学神经生物学系，北京 100069

摘要

成年哺乳动物大脑中的脑室室下区(subventricular zone, SVZ)和海马齿状回颗粒层下区(subgranular zone, SGZ)存在持续的神经发生。成年内源性神经发生不仅在正常脑功能中发挥重要作用，同时也在脑损伤或脑疾病的修复治疗中具有重要意义。本文通过综述成年内源性神经发生过程及其在创伤性脑损伤(traumatic brain injury, TBI)和缺血性脑卒中修复中的应用，讨论激活成年内源性神经发生修复脑损伤的策略及其促进脑损伤后功能恢复的意义。

关键词： 创伤性脑损伤; 缺血性脑卒中; 成年内源性神经发生; 功能恢复

Progress in application of adult endogenous neurogenesis in brain injury repair

BAI Tian-Yu¹, MU Jiao¹, HAO Peng², DUAN Hong-Mei², HAO Fei¹, ZHAO Wen², GAO Yu-Dan², WANG Zi-Jue², YANG Zhao-Yang², LI Xiao-Guang^1,2,*

¹Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China；²Department of Neurobiology, Capital Medical University, Beijing 100069, China

Abstract

Persistent neurogenesis exists in the subventricular zone (SVZ) of the ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus in the adult mammalian brain. Adult endogenous neurogenesis not only plays an important role in the normal brain function, but also has important significance in the repair and treatment of brain injury or brain diseases. This article reviews the process of adult endogenous neurogenesis and its application in the repair of traumatic brain injury (TBI) or ischemic stroke, and discusses the strategies of activating adult endogenous neurogenesis to repair brain injury and its practical significance in promoting functional recovery after brain injury.

Key words: traumatic brain injury; ischemic stroke; adult endogenous neurogenesis; functional recovery

收稿日期：　　录用日期：

通讯作者：李晓光　　E-mail: lxgchina@sina.com

DOI: 10.13294/j.aps.2023.0024

引用本文：

白天宇, 穆娇, 郝鹏, 段红梅, 郝飞, 赵文, 高钰丹, 王子珏, 杨朝阳, 李晓光. 成年内源性神经发生在脑损伤修复中的应用研究进展[J]. 生理学报 2023; 75 (2): 231-240.

BAI Tian-Yu, MU Jiao, HAO Peng, DUAN Hong-Mei, HAO Fei, ZHAO Wen, GAO Yu-Dan, WANG Zi-Jue, YANG Zhao-Yang, LI Xiao-Guang. Progress in application of adult endogenous neurogenesis in brain injury repair. Acta Physiol Sin 2023; 75 (2): 231-240 (in Chinese with English abstract).