过刊浏览

细胞程序性死亡在卵泡闭锁中的作用及机制

王鑫, 蒋易龙, 王泽龙, 康波^*

四川农业大学动物科技学院，成都 611130

摘要

卵泡颗粒细胞凋亡和自噬在动物卵巢卵泡闭锁过程中发挥重要的调控作用。新近研究表明，铁死亡和焦亡也参与卵巢卵泡闭锁过程。铁死亡是一种铁依赖性脂质过氧化和活性氧(reactive oxygen species, ROS)积累引起的细胞死亡形式。研究证实，自噬和凋亡介导的卵泡闭锁过程中也有典型的铁死亡特征。细胞焦亡是依赖于Gasdermin蛋白的促炎性细胞死亡，可通过调节卵泡颗粒细胞调控卵巢繁殖性能。本文综述了几种细胞程序性死亡独立或相互作用参与调控卵泡闭锁的作用及机制，以期扩展卵泡闭锁机制的理论研究，为细胞程序性细胞死亡诱导卵泡闭锁的作用机制提供理论参考。

关键词： 卵泡闭锁; 细胞程序性死亡; 细胞凋亡; 自噬; 铁死亡; 焦亡

Mechanism of programmed cell death in follicular atresia

WANG Xin, JIANG Yi-Long, WANG Ze-Long, KANG Bo^*

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Abstract

Apoptosis and autophagy of follicular granulosa cells play an important regulatory role in the process of ovarian follicular atresia in animals. Recent studies have shown that ferroptosis and pyroptosis are also involved in the process of ovarian follicular atresia. Ferroptosis is a form of cell death caused by iron-dependent lipid peroxidation and reactive oxygen species (ROS) accumulation. Studies have confirmed that autophagy- and apoptosis-mediated follicular atresia also have typical characteristics of ferroptosis. Pyroptosis is a pro-inflammatory cell death dependent on Gasdermin protein, which can regulate ovarian reproductive performance by regulating follicular granulosa cells. This article reviews the roles and mechanisms of several types of programmed cell death independently or interactively regulating follicular atresia, in order to expand the theoretical research on follicular atresia mechanism and provide the theoretical reference for the mechanism of programmed cell death-induced follicular atresia.

Key words: Follicular atresia; programmed cell death; apoptosis; autophagy; ferroptosis;

收稿日期：　　录用日期：

通讯作者：康波　　E-mail:

DOI: 10.13294/j.aps.2022.0076

引用本文：

王鑫, 蒋易龙, 王泽龙, 康波. 细胞程序性死亡在卵泡闭锁中的作用及机制[J]. 生理学报 2023; 75 (1): 82-90.

WANG Xin, JIANG Yi-Long, WANG Ze-Long, KANG Bo. Mechanism of programmed cell death in follicular atresia. Acta Physiol Sin 2023; 75 (1): 82-90 (in Chinese with English abstract).