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肌梭形态研究进展

连文玺¹, 饶家声¹, 郝柳芳², 王子珏², 段红梅², 杨朝阳², 李晓光^1,2,*

¹北京航空航天大学生物与医学工程学院，北京市生物材料与神经再生重点实验室，北京 100083；²首都医科大学基础医学院神经生物学教研室，北京 100069

摘要

肌梭是分布于骨骼肌中的重要本体感受器，参与调节躯体运动、维持姿势、控制运动速度变化等生理活动，是许多运动及代谢疾病的重要评估指标和治疗靶点。本文对肌梭在骨骼肌中的分布、机械力信号传递机制进行概述，并对肌梭形态和结构特点的研究进展进行综述。

关键词： 肌梭; 形态; 卫星细胞; 施万细胞; 成纤维/脂肪前体细胞

Research progress on muscle spindle morphology

LIAN Wen-Xi¹, RAO Jia-Sheng¹, HAO Liu-Fang², WANG Zi-Jue², DUAN Hong-Mei², YANG Zhao-Yang², LI Xiao-Guang^1,2,*

¹Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China；²Department of Neurobiology, Capital Medical University, Beijing 100069, China

Abstract

Muscle spindle is the key proprioceptor in skeletal muscles and plays important roles in many physiological activities, such as maintaining posture, regulating movement and controlling speed variation. It has significant clinical relevance and is emerging as a promising therapeutic target for the treatment of motor functional impairment and metabolic diseases. In this review, we summarized muscle spindle distribution and the mechanism of mechanical signal transmission, and reviewed the research progress on morphological and structural characteristics of muscle spindles.

Key words: muscle spindle; morphology; satellite cell; Schwann cell; fibro/adipogenic progenitor

收稿日期：　　录用日期：

通讯作者：李晓光　　E-mail: lxgchina@sina.com

引用本文：

连文玺, 饶家声, 郝柳芳, 王子珏, 段红梅, 杨朝阳, 李晓光. 肌梭形态研究进展[J]. 生理学报 2022; 74 (6): 1039-1047.

LIAN Wen-Xi, RAO Jia-Sheng, HAO Liu-Fang, WANG Zi-Jue, DUAN Hong-Mei, YANG Zhao-Yang, LI Xiao-Guang. Research progress on muscle spindle morphology. Acta Physiol Sin 2022; 74 (6): 1039-1047 (in Chinese with English abstract).