过刊浏览

血管刚度的检测与评估

张剑锐, 周菁^*

北京大学基础医学院生理学与病理生理学系；教育部分子心血管重点实验室；国家卫生健康委员会心血管分子生物学与调 节肽重点实验室；心血管受体研究北京市重点实验室，北京 100191

摘要

心血管系统的稳态受到众多理化因素的影响。血管刚度作为血管的物理性质之一，对维持血管的生理功能至关重要。血管刚度异常与高血压、心力衰竭等心血管疾病有很强的相关性，是临床上广泛应用的血管功能检测指标。本文综述了评估血管刚度的常用方法，如基于压痕法的杨氏模量直接测定以及基于超声等技术的间接检测法，并对这些方法的原理及评估方式进行分析。根据研究目的及研究对象的不同，研究者可以选择最合适的方法检测血管刚度，从而对血管功能进行有效评估。

关键词： 血管刚度; 杨氏模量; 脉搏波传导速度; 反射波增强指数

The detection and evaluation of vascular stiffness

ZHANG Jian-Rui, ZHOU Jing^*

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, National Health Commission; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China

Abstract

Cardiovascular homeostasis is regulated by both physical and chemical factors. Vascular stiffness, a physical property of vessel, is crucial in maintaining the physiological function of vasculature. Vascular stiffness has been indicated to be correlated with hypertension, heart failure and other cardiovascular diseases. It has been the most widely accepted clinical index for assessment of vascular function and dysfunction. This paper reviews the commonly used experimental and clinical techniques for evaluating vascular stiffness including direct detection of the Young’s modulus and indirect detection method that is based on ultrasound technique and others. Principles of these methodologies, as well as their advantages and disadvantages, are also presented here. Researchers and clinical staff are encouraged to choose the most suitable methods for detecting vascular stiffness according to their purposes and objects, so as to effectively evaluate vascular function.

Key words: vascular stiffness; Young’s modulus; pulse wave velocity (PWV); augmentation index (AIx)

收稿日期：　　录用日期：

通讯作者：周菁　　E-mail: jzhou@bjmu.edu.cn

引用本文：

张剑锐, 周菁. 血管刚度的检测与评估[J]. 生理学报 2022; 74 (6): 894-902.

ZHANG Jian-Rui, ZHOU Jing. The detection and evaluation of vascular stiffness. Acta Physiol Sin 2022; 74 (6): 894-902 (in Chinese with English abstract).