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血管钙化研究进展和临床实践的共识与争议

黄辉¹, 张爱华², 陈靖³, 袁凌青^4,*

¹中山大学附属第八医院，深圳 518033；²首都医科大学宣武医院，北京 100053；³复旦大学附属华山医院，上海 200040；⁴中南大学湘雅二医院，长沙 410011

摘要

血管钙化是一个主动的、活跃的，由众多因子参与调控的复杂病理过程。血管钙化可累及多个器官、系统，与心血管疾病、慢性肾脏病等疾病的发生率和死亡率升高密切相关，严重影响人民健康，因此日益受到重视。目前，血管钙化的发病机制学说及临床实践不断完善，主要包括钙磷失衡学说、血管平滑肌细胞转分化学说、骨稳态失衡学说、表观遗传学调控学说、炎症学说、细胞外基质学说、新细胞命运学说等，但仍存在许多未解之谜。由于血管钙化发生和发展涉及多个器官、系统，为总结近年来有关血管钙化的多个学科进展，本专家共识由国内从事血管钙化研究的临床医生和基础研究专家集体撰写，旨在从流行病学、发病机制以及防治方面系统阐述血管钙化的最新研究进展、治疗共识与争议，从而为此领域的深入研究提供理论依据和临床启示。

关键词： 血管钙化; 流行病学; 机制进展; 临床实践共识与争议

Consensus and controversy on research progress and clinical practice of vascularcalcification

HUANG Hui¹, ZHANG Ai-Hua², CHEN Jing³, YUAN Ling-Qing^4,*

¹The Eight Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China；²Xuanwu Hospital of Capital Medical University, Beijing 100053, China；³Huashan Hospital, Fudan University, Shanghai 200040, China；⁴The Second Xiangya Hospital of Central South University, Changsha 410011, China

Abstract

Vascular calcification is an active and complex pathological process regulated by several factors. Vascular calcification is closely related to the incidence and mortality of the cardiovascular disease, chronic kidney disease and other diseases, which affects multiple organs and systems, thus affecting people’s health. Therefore, more and more attention is paid to vascular calcification. At present, the pathogenesis and clinical practice of vascular calcification have been continuously improved, which mainly includes calcium and phosphorus imbalance theory, vascular smooth muscle cell transdifferentiation theory, bone homeostasis imbalance theory, epigenetic regulation theory, inflammation theory, extracellular matrix theory, new cell fate theory and so on. However, there are still many unsolved problems. Since the occurrence and development of vascular calcification affect multiple organs and systems, this expert consensus gathered clinicians and basic research experts engaged in the study of vascular calcification in order to summarize the progress of various disciplines related to vascular calcification in recent years. The purpose of this consensus is to systematically summarize the latest research progress, treatment consensus and controversy of vascular calcification from the aspects of epidemiology, pathogenesis, prevention and treatment, so as to provide theoretical basis and clinical enlightenment for in-depth research in this field.

Key words: vascular calcification; epidemiology; mechanism progress; consensus and controversy in clinical practice

收稿日期：　　录用日期：

通讯作者：袁凌青　　E-mail: allenylq@csu.edu.cn

引用本文：

黄辉, 张爱华, 陈靖, 袁凌青. 血管钙化研究进展和临床实践的共识与争议[J]. 生理学报 2022; 74 (6): 859-884.

HUANG Hui, ZHANG Ai-Hua, CHEN Jing, YUAN Ling-Qing. Consensus and controversy on research progress and clinical practice of vascularcalcification. Acta Physiol Sin 2022; 74 (6): 859-884 (in Chinese with English abstract).