ISSN 0371-0874, CN 31-1352/Q



倪苏婕1, 高健林1, 沈树泉2,*

1南通大学附属医院肿瘤科,南通 226006;2明尼苏达大学转化医学研究所,健康信息研究所,明尼阿波利斯,明尼苏达55455,美国



关键词: 新型冠状病毒; 脂质代谢; 饮食; 新型冠状病毒肺炎防治

Obesity and hypertriglyceridemia: high risks for disease severity and mortality in COVID-19 patients 

NI Su-Jie1, GAO Jian-Lin1, Steven S. Shen2,*

1Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226006, China;2The Institute for Health Informatics, Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN 55455, USA


As COVID-19 pandemic approaching its third year, more data have shown that obesity and hypertriglyceridemia are the high-risk factors for the major complications such as acute respiratory distress syndrome, thromboembolism, coagulopathy and cytokine storm, which are responsible for the majority of disease severity and mortality. In this review article, we have analyzed the public available clinical reports and laboratory research results of the COVID-19 studies by researchers and clinicians of many nations around the world. Many of these reports covered COVID-19 patients of different ethnic groups. We suggested that obesity and high triglycerides are high risks for severe COVID-19 and death. We also summarized the possible underlying molecular mechanism likely connecting the severe COVID-19 with obesity and hypertriglyceridemia. From public health perspective, we highlight the importance of the healthy diet and lifestyle in fighting against SARS-CoV-2 virus in long period of time. 

Key words: SARS-CoV-2; lipid metabolism; diet; COVID-19 prevention

收稿日期:  录用日期:

通讯作者:沈树泉  E-mail:

DOI: 10.13294/j.aps.2022.0080


倪苏婕, 高健林, 沈树泉. 肥胖和高甘油三酯血症与重症新型冠状病毒肺炎及其死亡相关联的临床证据及可能机制[J]. 生理学报 2022; 74 (5): 783-791.

NI Su-Jie, GAO Jian-Lin, Steven S. Shen. Obesity and hypertriglyceridemia: high risks for disease severity and mortality in COVID-19 patients . Acta Physiol Sin 2022; 74 (5): 783-791 (in Chinese with English abstract).