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肥胖和高甘油三酯血症与重症新型冠状病毒肺炎及其死亡相关联的临床证据及可能机制

倪苏婕¹, 高健林¹, 沈树泉^2,*

¹南通大学附属医院肿瘤科，南通 226006；²明尼苏达大学转化医学研究所，健康信息研究所，明尼阿波利斯，明尼苏达55455，美国

摘要

随着新型冠状病毒肺炎(简称“新冠肺炎”)大流行进入第三个年头，大量数据显示肥胖和高甘油三酯血症是新冠肺炎重症和死亡的重要危险因素，并与新冠肺炎各种并发症密切相关。这些并发症包括急性呼吸衰竭、血栓栓塞、凝血功能障碍，以及细胞因子风暴等，是新冠肺炎重症和致死的最常见和最根本原因。本文综合分析了近3年来公开发表的来自世界各地、不同种族的关于新冠肺炎的临床报道和研究分析，得出新冠肺炎重症与肥胖和高甘油三酯血症之间存在临床关联的结论。在分析了各种关于新冠病毒研究结果的同时，我们还探讨了肥胖和高甘油三酯血症与新冠肺炎重症之间相关联的可能分子基础。我们也从公共健康的角度，提出了改善饮食和生活方式来应对新冠病毒对人类健康带来长期挑战的策略。

关键词： 新型冠状病毒; 脂质代谢; 饮食; 新型冠状病毒肺炎防治

Obesity and hypertriglyceridemia: high risks for disease severity and mortality in COVID-19 patients 

NI Su-Jie¹, GAO Jian-Lin¹, Steven S. Shen^2,*

¹Department of Oncology, Affiliated Hospital of Nantong University, Nantong 226006, China；²The Institute for Health Informatics, Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN 55455, USA

Abstract

As COVID-19 pandemic approaching its third year, more data have shown that obesity and hypertriglyceridemia are the high-risk factors for the major complications such as acute respiratory distress syndrome, thromboembolism, coagulopathy and cytokine storm, which are responsible for the majority of disease severity and mortality. In this review article, we have analyzed the public available clinical reports and laboratory research results of the COVID-19 studies by researchers and clinicians of many nations around the world. Many of these reports covered COVID-19 patients of different ethnic groups. We suggested that obesity and high triglycerides are high risks for severe COVID-19 and death. We also summarized the possible underlying molecular mechanism likely connecting the severe COVID-19 with obesity and hypertriglyceridemia. From public health perspective, we highlight the importance of the healthy diet and lifestyle in fighting against SARS-CoV-2 virus in long period of time. 

Key words: SARS-CoV-2; lipid metabolism; diet; COVID-19 prevention

收稿日期：　　录用日期：

通讯作者：沈树泉　　E-mail: shens@umn.edu

DOI: 10.13294/j.aps.2022.0080

引用本文：

倪苏婕, 高健林, 沈树泉. 肥胖和高甘油三酯血症与重症新型冠状病毒肺炎及其死亡相关联的临床证据及可能机制[J]. 生理学报 2022; 74 (5): 783-791.

NI Su-Jie, GAO Jian-Lin, Steven S. Shen. Obesity and hypertriglyceridemia: high risks for disease severity and mortality in COVID-19 patients . Acta Physiol Sin 2022; 74 (5): 783-791 (in Chinese with English abstract).