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卒中后焦虑发生机制的研究进展

舒渝茜^1,2, 吴凡^1,2, 章帆^1,2, 鲁娇^1,2, 赵航^1,2, 王清^1,2, 何治^1,2,*

¹三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002；²三峡大学医学院，宜昌 443002

摘要

随着卒中发病率的增加，其已成为影响人类生命健康的重要疾病。部分卒中幸存者在后期出现不同程度的情绪和运动障碍，如卒中后焦虑(post-stroke anxiety, PSA)、卒中后抑郁(post-stroke depression, PSD)等，严重危害患者和家属的生活质量。当前对于PSA的发病机制研究尚不完全清楚，研究认为其主要与下丘脑-垂体-肾上腺素(hypothalamic-pituitary-adrenergic, HPA)轴失衡、神经递质紊乱、神经元兴奋性改变和细胞因子水平失衡，以及卒中发生脑区和心理生理等因素相关。本文对近年来PSA发病机制的研究进展进行综述。

关键词： 卒中; 焦虑; 发病机制

Research progress on the mechanism of post-stroke anxiety

SHU Yu-Qian^1,2, WU Fan^1,2, ZHANG Fan^1,2, LU Jiao^1,2, ZHAO Hang^1,2, WANG Qing^1,2, HE Zhi^1,2,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China；²Medical College, China Three Gorges University, Yichang 443002, China

Abstract

With the increase in stroke incidence, it has become an important disease threatening human life and health. Some stroke survivors have different degrees of mood and movement disorders in the later stages, such as post-stroke anxiety (PSA) and post-stroke depression (PSD), which seriously endanger the quality of life of patients and their families. The pathogenesis of PSA remains incompletely clear. Current research interest mainly focuses on the dysfunction of hypothalamic-pituitary-adrenergic (HPA) axis, neurotransmitter disorders, neuronal excitability changes, cytokine levels imbalance, stroke lesion site and psychophysiology. This article summarizes the research progress on the pathogenesis of PSA in recent years.

Key words: stroke; anxiety; pathogenesis

收稿日期：　　录用日期：

通讯作者：何治　　E-mail: hezhi@ctgu.edu.cn

DOI: 10.13294/j.aps.2022.0058

引用本文：

舒渝茜, 吴凡, 章帆, 鲁娇, 赵航, 王清, 何治. 卒中后焦虑发生机制的研究进展[J]. 生理学报 2022; 74 (4): 648-656.

SHU Yu-Qian, WU Fan, ZHANG Fan, LU Jiao, ZHAO Hang, WANG Qing, HE Zhi. Research progress on the mechanism of post-stroke anxiety. Acta Physiol Sin 2022; 74 (4): 648-656 (in Chinese with English abstract).