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慢性病贫血铁代谢调节机制的研究进展

米海潮¹, 崔芳², 杜玉涛¹, 王若潼¹, 张瑞¹, 史敏^2,*

¹河北医科大学第二医院检验科，石家庄 050000；²河北医科大学电镜实验中心，石家庄 050017

摘要

慢性病贫血(anemia of chronic disease, ACD)是世界上发病率仅次于缺铁性贫血的第二大类贫血，继发于各种慢性炎症性疾病。贫血的发生显著降低慢性病患者的生活质量，在某些疾病中，贫血甚至是一个独立的不良预后因素。研究证实，贫血大多与铁代谢异常有关，铁调素(hepcidin)是调节机体铁代谢的关键因素，有关铁调素调节机制被深入研究，其在ACD中的作用也被广泛关注。本文就近年有关铁调素在ACD中的作用及调节机制的研究进展进行综述，以期为ACD寻找有效治疗靶点，并为改善ACD患者生活质量提供新思路。

关键词： 慢性病贫血; 铁代谢; 铁调素; 调节机制

Research progress on the regulation mechanisms of iron metabolism in anemia of chronic disease

MI Hai-Chao¹, CUI Fang², DU Yu-Tao¹, WANG Ruo-Tong¹, ZHANG Rui¹, SHI Min^2,*

¹Department of Clinical Laboratory, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China；²Department of Electron Microscopy Laboratory Centre, Hebei Medical University, Shijiazhuang 050017, China

Abstract

Anemia of chronic disease (ACD), complicated by various chronic inflammatory diseases, is the second most prevalent type of anemia after iron deficiency anemia in the world. ACD significantly reduces the life quality of patients with chronic diseases, and represents an independent poor prognostic factor in certain chronic diseases. A large body of studies has demonstrated that most of anemia is related to abnormal iron metabolism. In the past decade, hepcidin, as a key factor in regulating iron metabolism, has attracted enormous attention due to its important role in the pathogenesis of ACD. This article reviews the research progress on the role and underlying regulatory mechanisms of hepcidin in ACD. We also discuss the potential of hepcidin as an effective therapeutic target for ACD treatment, in order to provide a new maneuver for improving the quality of ACD patients’ life.

Key words: anemia of chronic disease; iron metabolism; hepcidin; regulatory mechanism

收稿日期：　　录用日期：

通讯作者：史敏　　E-mail: sm8344@sina.com

DOI: 10.13294/j.aps.2022.0059

引用本文：

米海潮, 崔芳, 杜玉涛, 王若潼, 张瑞, 史敏. 慢性病贫血铁代谢调节机制的研究进展[J]. 生理学报 2022; 74 (4): 639-647.

MI Hai-Chao, CUI Fang, DU Yu-Tao, WANG Ruo-Tong, ZHANG Rui, SHI Min. Research progress on the regulation mechanisms of iron metabolism in anemia of chronic disease. Acta Physiol Sin 2022; 74 (4): 639-647 (in Chinese with English abstract).