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成纤维细胞生长因子21通过诱导自噬在心血管疾病中发挥保护作用

李英凯, 何松原, 王枞, 史雨晨, 柳景华^*

首都医科大学附属北京安贞医院冠心病中心，北京市心肺血管疾病研究所，北京 100029

摘要

成纤维细胞生长因子21 (fibroblast growth factor 21, FGF21)是成纤维细胞生长因子家族中一个具有内分泌性质的生长因子。既往报道显示，FGF21参与能量代谢的调节过程，并在冠状动脉粥样硬化性心脏病、糖尿病、非酒精性脂肪肝病等心血管相关疾病中具有保护作用。新近研究发现，FGF21在多种组织和器官中可诱导自噬，而自噬参与了包括血管钙化、动脉粥样硬化、心肌缺血/再灌注损伤在内的多种心血管疾病的病理过程。因此，有学者推测FGF21可能通过调控自噬在多种心血管相关疾病中发挥保护作用。本文就FGF21通过诱导自噬在心血管疾病中发挥保护作用的相关研究进展作一综述。

关键词： 成纤维细胞生长因子21; 自噬; 心血管疾病

Fibroblast growth factor 21 plays a protective role in cardiovascular diseases by inducing autophagy

LI Ying-Kai, HE Song-Yuan, WANG Cong, SHI Yu-Chen, LIU Jing-Hua^*

Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China

Abstract

Fibroblast growth factor 21 (FGF21) is a growth factor with endocrine function in the fibroblast growth factor family. Previous reports have shown that FGF21 is involved in the regulation of energy metabolism and plays a protective role in cardiovascular diseases such as coronary heart disease, diabetes, non-alcoholic fatty liver disease and so on. Recent studies have found that FGF21 can induce autophagy in a variety of tissues and organs, and autophagy is involved in many pathological processes of cardiovascular diseases, including vascular calcification, atherosclerosis, and myocardial ischemia-reperfusion injury. Therefore, FGF21 may play a protective role in a variety of cardiovascular diseases by regulating autophagy. This article reviews the research progress on the protective role of FGF21 in cardiovascular diseases by inducing autophagy.

Key words: fibroblast growth factor 21; autophagy; cardiovascular disease

收稿日期：　　录用日期：

通讯作者：柳景华　　E-mail: liujinghua@vip.sina.com

DOI: 10.13294/j.aps.2022.0061

引用本文：

李英凯, 何松原, 王枞, 史雨晨, 柳景华. 成纤维细胞生长因子21通过诱导自噬在心血管疾病中发挥保护作用[J]. 生理学报 2022; 74 (4): 633-638.

LI Ying-Kai, HE Song-Yuan, WANG Cong, SHI Yu-Chen, LIU Jing-Hua. Fibroblast growth factor 21 plays a protective role in cardiovascular diseases by inducing autophagy. Acta Physiol Sin 2022; 74 (4): 633-638 (in Chinese with English abstract).