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昼夜节律调节耳蜗对噪声敏感性研究进展

金宝玲, 吴菁, 崔钟丹, 唐佳, 陈其才, 付子英^*

华中师范大学生命科学学院，遗传调控与整合生物学湖北省重点实验室，武汉 430079

摘要

强烈的噪声会损伤耳蜗毛细胞、听神经、耳蜗毛细胞与听神经之间的突触连接，造成噪声性听力损失(noise-induced hearing loss, NIHL)。近年来的研究显示，动物耳蜗具有昼夜节律性，使得它们对昼夜噪声的敏感性不同。耳蜗昼夜节律与脑源性神经营养因子以及糖皮质激素水平之间存在着一定的关系，从而影响动物噪声暴露后听力损失的程度。本文综述了昼夜节律调节耳蜗对噪声敏感性研究进展，并对未来的研究方向进行了展望。

关键词： 噪声性听力损失; 昼夜节律; 脑源性神经营养因子; 糖皮质激素; 生物钟

Research progress of the regulation of cochlear sensitivity to noise by circadian rhythm

JIN Bao-Ling, WU Jing, CUI Zhong-Dan, TANG Jia, CHEN Qi-Cai, FU Zi-Ying^*

School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China

Abstract

High level noise can damage cochlear hair cells, auditory nerve and synaptic connections between cochlear hair cells and auditory nerve, resulting in noise-induced hearing loss (NIHL). Recent studies have shown that animal cochleae have circadian rhythm, which makes them different in sensitivity to noise throughout the day. Cochlear circadian rhythm has a certain relationship with brain-derived neurotrophic factor and glucocorticoids, which affects the degree of hearing loss after exposure to noise. In this review, we summarize the research progress of the regulation of cochlear sensitivity to noise by circadian rhythm and prospect the future research direction.

Key words: noise-induced hearing loss; circadian rhythm; brain-derived neurotrophic factor; glucocorticoids; biological clock

收稿日期：　　录用日期：

通讯作者：付子英　　E-mail: ccnufuzy@mail.ccnu.edu.cn

DOI: 10.13294/j.aps.2022.0048

引用本文：

金宝玲, 吴菁, 崔钟丹, 唐佳, 陈其才, 付子英. 昼夜节律调节耳蜗对噪声敏感性研究进展[J]. 生理学报 2022; 74 (3): 489-494.

JIN Bao-Ling, WU Jing, CUI Zhong-Dan, TANG Jia, CHEN Qi-Cai, FU Zi-Ying. Research progress of the regulation of cochlear sensitivity to noise by circadian rhythm. Acta Physiol Sin 2022; 74 (3): 489-494 (in Chinese with English abstract).