ISSN 0371-0874, CN 31-1352/Q



沈风晨, 庄守纲*

上海同济大学附属东方医院肾内科,上海 200120



关键词: 组蛋白去乙酰化; 急性肾损伤; 缺血再灌注; 中毒性肾病; 脓毒症; 横纹肌溶解

Histone deacetylases and acute kidney injury

SHEN Feng-Chen, ZHUANG Shou-Gang*

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China


Histone acetylation is one of the epigenetic modifications. Histone acetylation, which is catalyzed by histone acetyltransferases and negatively regulated by histone deacetylases, plays an important role in a variety of cellular physiological and pathophysiological processes. Recent studies have shown that histone deacetylases are involved in a variety of pathophysiological responses to acute kidney injury, such as apoptosis, dedifferentiation, proliferation and regeneration. This article reviews the role and underlying mechanism of histone deacetylases in acute kidney injury induced by ischemia reperfusion, nephrotoxicants, sepsis and rhabdomyolysis.

Key words: histone deacetylation; acute kidney injury; ischemia reperfusion; toxic nephrosis; sepsis; rhabdomyolysis

收稿日期:  录用日期:

通讯作者:庄守纲  E-mail:;

DOI: 10.13294/j.aps.2022.0013


沈风晨, 庄守纲. 组蛋白去乙酰化酶与急性肾损伤[J]. 生理学报 2022; 74 (1): 73-79.

SHEN Feng-Chen, ZHUANG Shou-Gang. Histone deacetylases and acute kidney injury. Acta Physiol Sin 2022; 74 (1): 73-79 (in Chinese with English abstract).