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细胞外囊泡在肾脏病治疗中的研究进展

汤涛涛, 吕林莉, 刘必成^*

东南大学肾脏病研究所，东南大学附属中大医院肾脏科，南京 210009

摘要

细胞外囊泡(extracellular vesicles, EVs)是细胞分泌的由脂质双分子层包绕形成的膜性囊泡，其内包含丰富的生物学信息，参与多种生理和病理过程。近年来，EVs在疾病治疗中也展现出了巨大应用前景，一方面来源于干细胞的EVs可以直接发挥治疗作用，另一方面EVs还可以作为一种天然的药物递送载体，为疾病的治疗提供新的给药策略。本文聚焦EVs在肾脏病治疗中的应用和研究进展。

关键词： 细胞外囊泡; 药物递送; 干细胞; 急性肾损伤; 慢性肾脏病

Research progress of extracellular vesicles in the treatment of renal disease

TANG Tao-Tao, LYU Lin-Li, LIU Bi-Cheng^*

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Extracellular vesicles (EVs) are lipid bilayer-enclosed structures containing diverse bioactive cargoes that play a major role in intercellular communication in both physiological and pathological conditions. Currently, the field of EV-based therapy has been rapidly growing, and two main therapeutic uses of EVs can be surmised: (i) exploiting stem cell-derived EVs as therapeutic agents; and (ii) employing EVs as natural therapeutic vectors for drug delivery. This review will discuss the recent advances in EV-based therapy in the treatment of renal disease.

Key words: extracellular vesicles; drug delivery; stem cell; acute kidney injury; chronic kidney disease

收稿日期：　　录用日期：

通讯作者：刘必成　　E-mail: liubc64@163.com

DOI: 10.13294/j.aps.2022.0004

引用本文：

汤涛涛, 吕林莉, 刘必成. 细胞外囊泡在肾脏病治疗中的研究进展[J]. 生理学报 2022; 74 (1): 67-72.

TANG Tao-Tao, LYU Lin-Li, LIU Bi-Cheng. Research progress of extracellular vesicles in the treatment of renal disease. Acta Physiol Sin 2022; 74 (1): 67-72 (in Chinese with English abstract).