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VEGF-A及其不同异构体在肾脏疾病中的研究进展

敬婧, 仲鑫, 刘必成, 吕林莉^*

东南大学肾脏病研究所，东南大学附属中大医院肾脏科，南京 210009

摘要

血管内皮生长因子-A (vascular endothelial growth factor-A, VEGF-A)是重要的血管生成因子，肾脏足细胞与上皮细胞是分泌VEGF-A的主要细胞类型，在肾脏病理生理过程中发挥重要作用。近年来随着对VEGF-A不同异构体功能的深入研究，以及对细胞外囊泡(extracellular vesicles, EVs)作为VEGF-A的新型分泌方式的认识，进一步关注和深入研究VEGF-A在肾脏损伤中的作用具有重要意义。本文主要从VEGF-A的表达、分泌、调控和生物学功能及VEGF-A不同异构体在肾脏病进展中的作用机制进行了综述，同时探讨了VEGF-A作为肾脏病诊断标志物和治疗靶点的研究进展。

关键词： 血管内皮生长因子; 肾脏疾病; 内皮细胞; 细胞外囊泡; 外泌体

Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li^*

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li* Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Vascular endothelial growth factor-A (VEGF-A) is a critical angiogenic factor which is mainly secreted from podocytes and epithelial cells in kidney and plays an important role in renal pathophysiology. In recent years, functions of different isoforms of VEGF-A and the new secretion approach via extracellular vesicles (EVs) have been identified. Thus, further understanding are needed for the role of VEGF-A and its isoforms in renal injury and repair. In this review, we summarized the expression, secretion and regulation of VEGF-A, its biological function, and the role of different isoforms of VEGF-A in the development of different renal diseases. Meanwhile, the research progress of VEGF-A as diagnostic marker and therapeutic target for renal diseases were discussed.

Key words: Vascular endothelial growth factor; renal disease; endothelial cell; extracellular vesicle; exosomes

收稿日期：　　录用日期：

通讯作者：吕林莉　　E-mail: lvlinli@seu.edu.cn

DOI: 10.13294/j.aps.2022.0008

引用本文：

敬婧, 仲鑫, 刘必成, 吕林莉. VEGF-A及其不同异构体在肾脏疾病中的研究进展[J]. 生理学报 2022; 74 (1): 59-66.

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li. Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease. Acta Physiol Sin 2022; 74 (1): 59-66 (in Chinese with English abstract).