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Wnt/β-catenin与肾脏损伤后的修复和纤维化

任倩, 陈炯城, 刘友华^*

南方医科大学南方医院肾内科，器官衰竭防治国家重点实验室，国家肾脏病临床医学研究中心，广州 510515

摘要

Wnt/β-catenin信号是一条进化上高度保守且极度复杂的发育信号通路，可调控胚胎发育、损伤修复以及多种人类疾病的发生、发展。大量证据表明，Wnt/β-catenin信号在肾脏早期发育中起关键作用，而在成年肾脏中则相对沉默。在多种肾脏病动物模型和人类肾脏疾病中它又被重新激活。急性肾损伤后Wnt/β-catenin的激活有助于受损肾小管的修复和再生。然而，该信号的持续激活与慢性肾脏疾病和肾纤维化的发生、发展密切相关。在本文中，我们对Wnt/β-catenin信号通路的组成及其转导机制，以及它在肾脏损伤后修复和纤维化过程中的作用进行较为系统的综述。深入阐明此信号通路的机制可能为将来防治肾脏病提供新的靶点和策略。

关键词： Wnt/β-catenin; 急性肾损伤; 损伤修复; 肾纤维化; 慢性肾脏病

Wnt/β-catenin signaling in kidney repair and fibrosis after injury

REN Qian, CHEN Jiong-Cheng, LIU Youhua^*

Division of Nephrology, Nanfang Hospital, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Southern Medical University, Guangzhou 510515, China

Abstract

Wnt/β-catenin is an evolutionarily conserved, complex developmental signal pathway that regulates embryogenesis, cell fate, tissue homeostasis, injury repair, and the pathogenesis of human diseases. Mounting evidence demonstrates that Wnt/β-catenin signaling plays a key role in early nephrogenesis. It is relatively silent in normal adult kidneys but reactivated in a wide variety of animal models of nephropathies and in human kidney diseases. Activation of Wnt/β-catenin after acute kidney injury contributes to proper repair and regeneration of damaged renal tubules. However, sustained activation of this signal cascade is closely related to the development and progression of fibrotic chronic kidney disease. In this paper, we systematically review the components and mechanisms of Wnt/β-catenin signaling and its role in kidney repair and fibrosis after injury. A better delineation of the mechanisms of this pathway will provide novel targets and new strategies for designing effective treatment of various kidney diseases. 

Key words: Wnt/β-catenin; acute kidney injury; injury repair; kidney fibrosis; chronic kidney disease

收稿日期：　　录用日期：

通讯作者：刘友华　　E-mail: liuyh@smu.edu.cn

DOI: 10.13294/j.aps.2022.0003

引用本文：

任倩, 陈炯城, 刘友华. Wnt/β-catenin与肾脏损伤后的修复和纤维化[J]. 生理学报 2022; 74 (1): 15-27.

REN Qian, CHEN Jiong-Cheng, LIU Youhua. Wnt/β-catenin signaling in kidney repair and fibrosis after injury. Acta Physiol Sin 2022; 74 (1): 15-27 (in Chinese with English abstract).