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外泌体源性microRNA在系统性红斑狼疮中的研究进展

沙小琪, 葛星宇, 金怡, 陈恬, 季娟, 顾志峰^*

南通大学附属医院风湿免疫科，南通 226000

摘要

外泌体是一种纳米大小的膜性囊泡，体内几乎所有类型的细胞均可分泌，并通过自分泌及旁分泌的形式参与细胞间通讯。外泌体源性microRNA (miRNA)稳定存在于血浆、尿液和其他体液中，具有多种生物学功能。外泌体源性miRNA在系统性红斑狼疮(systemic lupus erythematosus, SLE)的发生和发展、免疫调控中发挥重要作用。近期研究表明，外泌体源性miRNA在SLE发病机制研究、早期诊断、治疗等方面都具有良好的应用前景。因此，本综述旨在介绍SLE中外泌体源性miRNA的研究进展，以分析其潜在的应用价值。

关键词： 外泌体; microRNA; 免疫; 系统性红斑狼疮; 狼疮肾炎

分类号：R593.2

Exosomal microRNAs: an emerging player in systemic lupus erythematosus 

SHA Xiao-Qi, GE Xing-Yu, JIN Yi, CHEN Tian, JI Juan, GU Zhi-Feng^*

Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226000, China

Abstract

Exosomes are nanometer-sized membranous extracellular vesicles that can be secreted by almost all types of cells in the body. Exosomes are involved in cell-to-cell communication through autocrine and paracrine forms. Exosomal microRNAs (miRNAs) are stable in plasma, urine and other body fluids, and have various biological functions. They play an irreplaceable role in the occurrence, development, immune regulation of systemic lupus erythematosus (SLE). Recent studies have proposed that exosomal miRNAs have promising application prospects in the pathogenesis, early diagnosis, and treatment of SLE. Therefore, this review aims to introduce the current research progress on exosomal miRNAs in SLE and analyze their potential application value.

Key words: exosomes; microRNAs; immune; systemic lupus erythematosus; lupus nephritis

收稿日期：2020-12-04　　录用日期：2021-07-12

通讯作者：顾志峰　　E-mail: guzf@ntu.edu.cn

引用本文：

沙小琪, 葛星宇, 金怡, 陈恬, 季娟, 顾志峰. 外泌体源性microRNA在系统性红斑狼疮中的研究进展[J]. 生理学报 2021; 73 (6): 1035-1042.

SHA Xiao-Qi, GE Xing-Yu, JIN Yi, CHEN Tian, JI Juan, GU Zhi-Feng. Exosomal microRNAs: an emerging player in systemic lupus erythematosus . Acta Physiol Sin 2021; 73 (6): 1035-1042 (in Chinese with English abstract).