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闭合蛋白(occludin)在血管内皮损伤中的研究进展

段艳茹¹, 杜芸辉², 刘慧荣^1,*

¹首都医科大学基础医学院，北京 100069；²首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所，北京 100069

摘要

内皮细胞紧密连接蛋白在维持血管内皮结构和生理功能完整性上具有十分重要的作用。闭合蛋白(occludin)作为紧密连接蛋白中最具代表性的蛋白，主要负责密封细胞间连接、维持细胞通透性、参与维持血管内皮的完整性。近年来的研究显示，许多疾病如脑中风、动脉粥样硬化、肺动脉高压等均出现内皮细胞紧密连接蛋白的表达和功能异常，提示其与血管疾病发生和发展有着千丝万缕的联系。本文从occludin的生物学信息、occludin发挥血管内皮保护作用的信号通路、occludin与血管内皮损伤相关疾病的关系出发，就近年来occludin与血管内皮损伤之间关系的研究进展作一综述。

关键词： 闭合蛋白; 血管内皮; 保护效应

分类号：R34

Research advances of occludin in vascular endothelial injury

DUAN Yan-Ru¹, DU Yun-Hui², LIU Hui-Rong^1,*

¹College of Basic Medical Sciences, Capital Medical University, Beijing 100069, China ；²Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100069, China

Abstract

Endothelial tight junctions (TJs) serve as an important barrier in vascular endothelial structure and maintain vascular function homeostasis. Occludin, the most representative tight junction protein, is involved in sealing cell connections and maintaining the integrity and permeability of vascular endothelium. Recent studies have shown that alterations in the expression, distribution, and structure of endothelial TJs may lead to many related vascular diseases and pathologies (such as stroke, atherosclerosis, and pulmonary hypertension etc.). Here, we reviewed the research advances on the relationship between occludin and vascular endothelial injury, including the biological information of occludin, the signal pathways that occludin exerts the protective effect of vascular endothelium, and the relationship between occludin and vascular endothelial injury-related diseases.

Key words: occludin; vascular endothelium; protective effect

收稿日期：2020-10-30　　录用日期：2021-03-11

通讯作者：刘慧荣　　E-mail: liuhr2000@126.com

引用本文：

段艳茹, 杜芸辉, 刘慧荣. 闭合蛋白(occludin)在血管内皮损伤中的研究进展[J]. 生理学报 2021; 73 (6): 931-939.

DUAN Yan-Ru, DU Yun-Hui, LIU Hui-Rong. Research advances of occludin in vascular endothelial injury. Acta Physiol Sin 2021; 73 (6): 931-939 (in Chinese with English abstract).