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SIRT1基因在抑郁症中的作用及机制研究进展

国威¹, 肖溪¹, 田裕涛¹, 杨佳佳^1,2,*

¹天津大学医学工程与转化医学研究院，天津 300072 ；²天津大学精密仪器与光电子工程研究院，天津 300072

摘要

抑郁症是一类高致残率且难治愈的精神类疾病，目前其临床诊断和治疗都面临很大的困难，因此研究抑郁症患病机制，寻找抑郁症的潜在治疗靶点，并开发有效临床治疗手段刻不容缓。沉默信息调节因子2同源体1 (silent mating type information regulator 2 homolog 1, SIRT1)作为一种去乙酰化酶，参与细胞衰老、癌症、心血管疾病等多种生物学过程。近年来，越来越多的研究发现SIRT1基因在抑郁症发病过程中发挥了重要的作用，但是其机制尚不明确。本文主要总结了海马、前额叶皮层、杏仁核、下丘脑视交叉上核脑区和伏隔核中SIRT1基因影响抑郁症病理过程的相关研究进展，以期为抑郁症机制研究和抗抑郁药物的研发提供一定的参考和帮助。

关键词： SIRT1; 抑郁症; 海马; 前额叶皮层; 杏仁核

分类号：R749;Q189

The role and mechanism of SIRT1 gene in depression

GUO Wei¹, XIAO Xi¹, TIAN Yu-Tao¹, YANG Jia-Jia^1,2,*

¹ Institute of Medical Engineering & Translational Medicine, Tianjin University, Tianjin 300072, China；²School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China

Abstract

As a kind of mental illness, depression produces great difficulties in clinical diagnosis and treatment, and has a high disability rate. It is urgent to clarify the mechanism of depression to find potential therapeutic targets and effective clinical treatment methods. As a deacetylase, silent mating type information regulator 2 homolog 1 (SIRT1) is involved in many biological processes such as cell aging, cancer, and cardiovascular disease. In recent years, more and more studies have found that SIRT1 gene plays an important role in the pathogenesis of depression, but the mechanism is still unclear. Therefore, this review mainly summarizes the relevant research progress on the role and mechanism of SIRT1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression.

Key words: SIRT1; depression; hippocampus; prefrontal cortex; amygdala

收稿日期：2020-09-18　　录用日期：2020-12-24

通讯作者：杨佳佳　　E-mail: jiajia.yang@tju.edu.cn

DOI: 10.13294/j.aps.2021.0028

引用本文：

国威, 肖溪, 田裕涛, 杨佳佳. SIRT1基因在抑郁症中的作用及机制研究进展[J]. 生理学报 2021; 73 (5): 828-834.

GUO Wei, XIAO Xi, TIAN Yu-Tao, YANG Jia-Jia. The role and mechanism of SIRT1 gene in depression. Acta Physiol Sin 2021; 73 (5): 828-834 (in Chinese with English abstract).