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前列腺素E2对肾脏集合管水转运的调控作用

李彧媛¹, 张晓燕^2,*

¹大连医科大学医学科学研究院，大连 116044；²华东师范大学医学与健康研究院，上海 200241

摘要

前列腺素E2 (prostaglandin E2, PGE2)是一种脂质介质，通过与4种G蛋白耦联受体(EPl、EP2、EP3、EP4)作用，参与多种生理和病理生理过程。越来越多的证据表明，PGE2通过多种机制参与肾脏水转运的调节以维持机体水稳态。水稳态主要依赖精氨酸血管加压素(arginine vasopressin, AVP)对水通道蛋白-2 (aquaporin-2, AQP2)在肾脏集合管上皮细胞的表达和膜转位的调节来维持。近年来，局部调控因素如PGE2在肾脏集合管水重吸收调节中的作用受到了广泛关注。本文综述了PGE2在肾脏集合管水重吸收调节中的作用，并讨论了其合成通路限速酶和各种EP受体在其中的不同作用机制，为尿崩症、水肿等临床体液紊乱疾病的治疗提供新的策略。

关键词： 前列腺素E2; 水转运; 集合管; 血管加压素; 水通道蛋白-2

分类号：R334

Role of prostaglandin E2 in the modulation of renal water transport 

LI Yu-Yuan¹, ZHANG Xiao-Yan^2,*

¹Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China；²Health Science Center, East China Normal University, Shanghai 200241, China

Abstract

Prostaglandin E2 (PGE2), a bioactive lipid mediator, is one of the most important locally acting factors involved in a variety of physiological and pathophysiological processes. PGE2 binds with four EP receptors (EP1–4) to activate G protein-coupled receptor signaling responses. Recent functional and molecular studies have revealed that PGE2 plays an essential role in regulation of renal fluid transport via a variety of mechanisms. The water balance mainly depends on the regulation of aquaporin-2 (AQP2) by arginine vasopressin (AVP) in renal collecting duct principal cells. In recent years, increasing evidence suggests that PGE2 plays an important role in renal water reabsorption in the collecting ducts. In this paper, we reviewed the role of PGE2 and its receptors in the regulation of water reabsorption in the kidney, which may provide a new therapeutic strategy for many diseases especially nephrogenic diabetes insipidus. 

Key words: prostaglandin E2; water transport ; collecting ducts; arginine vasopressin; aquaporin-2

收稿日期：2020-11-17　　录用日期：2021-02-08

通讯作者：张晓燕　　E-mail: xyzhang@hsc.ecnu.edu.cn

DOI: 10.13294/j.aps.2021.0055

引用本文：

李彧媛, 张晓燕. 前列腺素E2对肾脏集合管水转运的调控作用[J]. 生理学报 2021; 73 (4): 681-689.

LI Yu-Yuan, ZHANG Xiao-Yan. Role of prostaglandin E2 in the modulation of renal water transport . Acta Physiol Sin 2021; 73 (4): 681-689 (in Chinese with English abstract).