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花生四烯酸代谢与健康和疾病——序言

张晓燕¹, 朱毅², 管又飞^3,*

¹华东师范大学医学与健康研究院，上海 200241；²天津医科大学生理学与病理生理学系，天津 300070；³大连医科大学医学科学研究院，大连 116044

摘要

脂肪酸(fatty acid)作为重要的营养素对维持生命健康发挥不可或缺的作用。根据含碳原子的多少，脂肪酸可以分为短链(含2~4碳原子)、中链(含6~12碳原子)、长链(含14个及以上碳原子)脂肪酸；根据饱和度，脂肪酸又可分为饱和、单不饱和、多不饱和脂肪酸(polyunsaturated fatty acids, PUFA)；根据首个不饱和键距离碳链甲基端的位置，PUFA还可以进一步分为ω-3 PUFA (从脂肪酸的甲基端即ω端开始，第一个不饱和双键出现在第3和第4个碳原子之间)和ω-6 PUFA。其中花生四烯酸(arachidonic acid, AA)和二十碳五烯酸(eicosapentaenoic acid, EPA)及二十二碳六烯酸(docosahexaenoic acid, DHA)分别是ω-6 PUFA和ω-3 PUFA的代表，具有广泛而重要的生物学功能，与生命健康和疾病发生及治疗有密切的关系。

Arachidonic acid metabolism in health and disease: An introduction

ZHANG Xiao-Yan¹, ZHU Yi², GUAN You-Fei^3,*

¹Health Science Center, East China Normal University, Shanghai 200241, China；²Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China；³dvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Fatty acids play an essential role in maintaining life and health. Depending on how many carbon atoms contain, fatty acids can be divided into short chains (including 2~4 carbon atoms), medium chains (including 6~12 carbon atoms), long chains (containing 14 and more carbon atoms) fatty acids; Depending on the saturation degree, fatty acids can also be divided into saturated, monounsaturated, and polyunsaturated fatty acids (polyunsaturated fatty acids, PUFA); Depending on the position of the first unsaturated bond from the methyl end of the carbon chain, PUFA can also be further divided into ω-3 PUFA (starting from the methyl end of fatty acids, the ω end, The first unsaturated double bond appears between the third and fourth carbon atoms) and ω-6 PUFA. Among them, arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent ω-6 and ω-3 PUFA, respectively. They have extensive and important biological functions and are closely related to life, health and disease occurrence and treatment.

收稿日期：　　录用日期：

通讯作者：管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2021.0065

引用本文：

张晓燕, 朱毅, 管又飞. 花生四烯酸代谢与健康和疾病——序言[J]. 生理学报 2021; 73 (4): 535-538.

ZHANG Xiao-Yan, ZHU Yi, GUAN You-Fei. Arachidonic acid metabolism in health and disease: An introduction. Acta Physiol Sin 2021; 73 (4): 535-538 (in Chinese with English abstract).