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细胞因子在动脉粥样硬化发病中的作用机制及相关治疗举措研究现状

李志明, 王铭洁^*

上海市小分子活性物质重点实验室，复旦大学基础医学院生理与病理生理学系，上海市高水平地方高校重点创新团队，上海 200032

摘要

动脉粥样硬化是一种慢性炎症性疾病，开展细胞因子相关研究为动脉粥样硬化的预防和治疗提供了重要方向。细胞因子由不同类型的细胞产生，作用于一系列靶点，在动脉粥样硬化的发病和进展过程中起关键作用。本文概述了动脉粥样硬化有关的主要促炎和抗炎细胞因子及其作用机制，归纳了现阶段有关动脉粥样硬化细胞因子的针对性治疗措施，并对细胞因子在动脉粥样硬化防治方面的研究和治疗前景进行展望。

关键词： 动脉粥样硬化; 细胞因子; 炎症信号; 治疗措施

分类号：R33

Current studies of cytokines in the pathogenesis of atherosclerosis and its therapeutic measures

LI Zhi-Ming, WANG Ming-Jie^*

Shanghai Key Laboratory of Bioactive Small Molecules, Department of physiology and pathophysiology, school of basic medical sciences, Shanghai Key Innovation Team of High-Level Local Universities, fudan university, shanghai 200032, China

Abstract

Atherosclerosis is a chronic inflammatory disease. Cytokine-related research provides an important direction for the prevention and treatment of atherosclerosis. Cytokines, produced by different types of cells and acting on a range of targets, play a key role in the pathogenesis and progression of atherosclerosis. This review summarizes the main pro-inflammatory and anti-inflammatory cytokines related to atherosclerosis and their underlying mechanism. We also outline current anti-atherosclerosis treatments targeting cytokines. The research and treatment prospects of cytokines in the prevention and treatment of atherosclerosis are discussed briefly as well.

Key words: Atherosclerosis; cytokines; inflammatory signal; therapy

收稿日期：2020-08-15　　录用日期：2020-12-24

通讯作者：王铭洁　　E-mail: mjwang@shmu.edu.cn

DOI: 10.13294/j.aps.2021.0027

引用本文：

李志明, 王铭洁. 细胞因子在动脉粥样硬化发病中的作用机制及相关治疗举措研究现状[J]. 生理学报 2021; 73 (3): 501-508.

LI Zhi-Ming, WANG Ming-Jie. Current studies of cytokines in the pathogenesis of atherosclerosis and its therapeutic measures. Acta Physiol Sin 2021; 73 (3): 501-508 (in Chinese with English abstract).