过刊浏览

精神分裂症的脑网络特征与症状的联系

梁佳琳¹, 谢烨², 库逸轩^2,*

¹深圳大学心理学院，深圳 518067；²中山大学心理学系脑与心理健康研究中心，广州 510006

摘要

精神分裂症的起因尚未明确，与之相关的脑机制异常也未得到统一的结论。近年来精神分裂症患者的症状与大脑功能连接脑网络之间的关系逐渐受到研究者的重视，因此也引起该领域学者对其中问题的广泛讨论。本文对精神分裂症相关的静息态和任务态功能连接和脑网络研究进行综述，详细梳理精神分裂症患者症状与大规模脑网络特征之间的关系，以期为精神分裂症诊断与治疗提出新的研究方向。

关键词： 精神分裂症; 脑网络; 症状; 静息态功能磁共振; 任务态功能磁共振

分类号：R749.3;R445.2

The relationship between brain networks and symptoms of schizophrenia

LIANG Jia-Lin¹, XIE Ye², KU Yi-Xuan^2,*

¹School of Psychology, Shenzhen University, Shenzhen 518067, China；²Brain and Mental Well-being Center, Department of Psychology, Sun Yat-sen University, Guangzhou 510006, China

Abstract

The pathogenesis of schizophrenia (SCZ) is not yet clear, and the pathological changes of the brain activity remains debatable. There are still numerous unresolved issues and debates regarding the relationship between functional connection of the brain network and the symptoms of SCZ. In this paper, we provide a comprehensive review of recent research progresses on resting-state and task-based brain networks, which covers the symptoms of SCZ. Furthermore, we discuss the relationship between large-scale brain networks and SCZ symptoms, and propose possible future research directions in the field of SCZ diagnosis and treatment.

Key words: Schizophrenia; brain network; symptoms; resting-state fMRI; task-based fMRI

收稿日期：2020-09-13　　录用日期：2021-03-11

通讯作者：库逸轩　　E-mail: kuyixuan@mail.sysu.edu.cn; kuyixuan@gmail.com

DOI: 10.13294/j.aps.2021.0034

引用本文：

梁佳琳, 谢烨, 库逸轩. 精神分裂症的脑网络特征与症状的联系[J]. 生理学报 2021; 73 (3): 446-458.

LIANG Jia-Lin, XIE Ye, KU Yi-Xuan. The relationship between brain networks and symptoms of schizophrenia. Acta Physiol Sin 2021; 73 (3): 446-458 (in Chinese with English abstract).