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氧化磷脂与动脉粥样硬化

赵敏, 刘伯言, 秦树存^*

山东第一医科大学(山东省医学科学院)动脉粥样硬化研究所，基础医学院，泰山氢生物医学研究院，泰安 271000

摘要

磷脂是构成生物膜和脂蛋白的重要成分，容易在自由基或非自由基以及酶促条件下发生氧化修饰，形成氧化磷脂(oxidized phospholipids, OxPLs)，并进一步产生具有不同生物活性的氧化产物。临床证据表明，OxPLs在动脉粥样硬化(atherosclerosis, AS)发展过程中不断生成和转化，并在病变处积累。OxPLs是一种高度异质性混合物，可通过多种相关受体或信号通路影响AS病变进程。本文综述了磷脂氧化过程、相关产物，以及OxPLs通过与内皮细胞、单核/巨噬细胞、平滑肌细胞、血小板和脂蛋白相互作用参与AS病变过程，并对近年来将OxPLs作为抑制AS靶点的研究进展进行了总结。

关键词： 氧化磷脂; 磷脂氧化产物; 酶促氧化; 非酶促氧化; 动脉粥样硬化

分类号：R3

Oxidized phospholipids and atherosclerosis

ZHAO Min, LIU Bo-Yan, QIN Shu-Cun^*

Institute of Atherosclerosis, College of Basic Medical Sciences, and Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China

Abstract

Phospholipids are important components of biomembrane and lipoproteins. Phospholipids can be oxidized by free radicals/nonradicals and enzymes to form oxidized phospholipids (OxPLs), which can lead to further generation of oxidation products with different biological activities. Clinical evidence shows that OxPLs are constantly generated and transformed during the pathogenesis of atherosclerosis and accumulated at the lesion sites. OxPLs are highly heterogeneous mixtures that can influence the progress of atherosclerosis through a variety of related receptors or signaling pathways. This review summarizes the process of phospholipid oxidation, the related products, the interaction of OxPLs with endothelial cells, monocytes/macrophages, smooth muscle cells, platelets and lipoproteins involved in the pathological process of atherosclerosis, and the progress of the researches using OxPLs as a target to inhibit atherosclerosis in recent years.

Key words: oxidized phospholipids; phospholipid oxidation products; enzymatic oxidation; non-enzymatic oxidation; atherosclerosis

收稿日期：2020-04-17　　录用日期：2020-08-17

通讯作者：秦树存　　E-mail: scqin@sdfmu.edu.cn

DOI: 10.13294/j.aps.2020.0057

引用本文：

赵敏, 刘伯言, 秦树存. 氧化磷脂与动脉粥样硬化[J]. 生理学报 2021; 73 (1): 69-81.

ZHAO Min, LIU Bo-Yan, QIN Shu-Cun. Oxidized phospholipids and atherosclerosis. Acta Physiol Sin 2021; 73 (1): 69-81 (in Chinese with English abstract).