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空间记忆中海马神经元集群的序列编码特性与机制研究进展

张艺元^1,2, 朱楠^1,2, 杨佳佳^1,2, 郑晨光^1,3,2,*

¹天津大学医学工程与转化医学研究院，天津 300072；²天津市脑科学与神经工程重点实验室，天津 300072；³天津大学精密仪器与光电子工程学院，天津 300072

摘要

空间记忆的形成、巩固与检索依赖于海马中位置细胞集群的序列性放电模式。位置细胞集群在清醒运动状态下产生的theta序列有助于空间记忆获取，并且具有轨迹预测、促进决策等特性；而在清醒静息和慢波睡眠状态下产生的尖波-涟漪(sharp wave-ripples, SWRs)重放序列有助于空间记忆的巩固与检索。本综述主要总结了theta序列和SWRs重放序列的基本特性，探讨了二者的形成机制以及在空间记忆形成中的关系，总结了现存问题并展望其未来的研究方向，以期为相关研究提供新思路。

关键词： 空间记忆; 位置细胞; theta序列; SWRs重放序列

分类号：Q42;R338;R318

Progress in the encoding characteristics and mechanisms of hippocampal neural assemble sequences in spatial memory

ZHANG Yi-Yuan^1,2, ZHU Nan^1,2, YANG Jia-Jia^1,2, ZHENG Chen-Guang^1,1,2,*

¹Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China；²Tianjin Key Laboratory of Brain Science and Neuroengineering, Tianjin 300072, China

Abstract

The formation, consolidation and retrieval of spatial memory depend on sequential firing patterns of place cells assembling in the hippocampus. Theta sequences of place cells during behavior play a role in acquisition of spatial memory, trajectory prediction and decision making. In awake rest and slow wave sleep, place cell sequences occur during the sharp wave-ripples (SWRs), called “replay”, which is crucial for memory consolidation and retrieval. In this review, we summarize the functional significances of theta sequences and SWRs replay sequences and the mechanism of these sequences. We also discuss the relationship between theta and replay sequences with the formation of spatial memory. We propose the research direction in this field in future and aim to provide new ideas for related researches.

Key words: spatial memory; place cell; theta sequences; sharp wave-ripples replay sequences

收稿日期：2020-01-20　　录用日期：2020-06-08

通讯作者：郑晨光　　E-mail: cgzheng@tju.edu.cn

DOI: 10.13294/j.aps.2020.0081

引用本文：

张艺元, 朱楠, 杨佳佳, 郑晨光. 空间记忆中海马神经元集群的序列编码特性与机制研究进展[J]. 生理学报 2020; 72 (6): 793-803.

ZHANG Yi-Yuan, ZHU Nan, YANG Jia-Jia, ZHENG Chen-Guang. Progress in the encoding characteristics and mechanisms of hippocampal neural assemble sequences in spatial memory. Acta Physiol Sin 2020; 72 (6): 793-803 (in Chinese with English abstract).