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氧感受与适应机制的研究进展

沈安然¹, 王彬^1,2, 刘必成^1,2,*

¹东南大学肾脏病研究所，南京 210009；²东南大学附属中大医院肾脏病科，南京 210009

摘要

机体在低氧状态下会产生一系列生理反应，以适应生理功能的需要。该反应包括肾脏在内的全身各个器官和细胞分子水平的动员，并随着低氧程度和持续时间不同而变化，细胞从适应到产生损伤性改变。过去20多年来，低氧诱导因子(hypoxia-inducible factor, HIF)调控机体红细胞生成的机制逐渐被阐明，这同时也为诸如肾性贫血之类的低氧相关性疾病的治疗开辟了新的方向。本文对细胞氧感受与适应机制方面的研究进展进行综述。

关键词： 氧感受; 适应; 机制

分类号：R332;R363

New advances in oxygen sensing and adaptive mechanism

SHEN An-Ran¹, WANG Bin^1,2, LIU Bi-Cheng^1,2,*

¹Institute of Nephrology, Southeast University, Nanjing 210009, China；²Department of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Under the hypoxic condition, organs or cells trigger a series of reactions or responses to adapt to the physiological requirement. These responses involve a complex regulation at different levels from organs, in particular the kidney (producing erythropoietin), to cells throughout the body. Actually, the responses to hypoxia from adaption to injury largely depend on the degree and time of hypoxia.  In the past two decades, with the discovery of hypoxia-inducible factor (HIF), the mechanisms of erythropoiesis regulation were elucidated gradually, which has provided a novel therapeutic strategy for hypoxia-related diseases, especially renal anemia. In this review we focus on the latest advances in oxygen sensing and adaptive mechanism.

Key words: oxygen sensing; adaption; mechanism

收稿日期：2019-12-09　　录用日期：2020-01-29

通讯作者：刘必成　　E-mail: liubc64@163.com

DOI: 3294/j.aps.2020.0068

引用本文：

沈安然, 王彬, 刘必成. 氧感受与适应机制的研究进展[J]. 生理学报 2020; 72 (5): 660-666.

SHEN An-Ran, WANG Bin, LIU Bi-Cheng. New advances in oxygen sensing and adaptive mechanism. Acta Physiol Sin 2020; 72 (5): 660-666 (in Chinese with English abstract).