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呼吸系统中上皮-间质转化的研究进展及细胞黏附连接调控机制

谭眉灵, 龙春姣, 蒋旺, 王金美, 皮姣, 秦晓群, 向阳^*

中南大学基础医学院生理学系，长沙 410078

摘要

近年来的研究证实，上皮-间质转化(epithelial-mesenchymal transition, EMT)对呼吸系统发育和疾病有重要作用。细胞间的连接缺失是EMT的关键环节。各类黏附分子的平衡表达对于维持上皮细胞正常结构和功能稳态有重要意义。本文综述了EMT在肺发育、肺损伤修复以及肺部慢性疾病中的研究进展，并结合EMT分子事件的详细过程，就细胞连接结构和细胞黏附分子对EMT的影响作一概述。

关键词： 上皮-间质转化; 肺; 气道上皮细胞; 细胞连接; 黏附分子

分类号：R332

Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion

TAN Mei-Ling, LONG Chun-Jiao, JIANG Wang, WANG Jin-Mei, PI Jiao, QIN Xiao-Qun, XIANG Yang^*

Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410078, China

Abstract

Epithelial-mesenchymal transition (EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.

Key words: epithelial-mesenchymal transition; lung; airway epithelium; cell junction; adhesion molecules

收稿日期：2019-10-24　　录用日期：2020-03-19

通讯作者：向阳　　E-mail: xiangyang@csu.edu.cn

DOI: 10.13294/j.aps.2020.0043

引用本文：

谭眉灵, 龙春姣, 蒋旺, 王金美, 皮姣, 秦晓群, 向阳. 呼吸系统中上皮-间质转化的研究进展及细胞黏附连接调控机制[J]. 生理学报 2020; 72 (5): 605-616.

TAN Mei-Ling, LONG Chun-Jiao, JIANG Wang, WANG Jin-Mei, PI Jiao, QIN Xiao-Qun, XIANG Yang. Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion. Acta Physiol Sin 2020; 72 (5): 605-616 (in Chinese with English abstract).