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内源性骨髓间充质干细胞在肺纤维化中的研究进展

李小红¹, 罗自强^2,*

¹中南大学湘雅二医院病理科，长沙 410011；²中南大学基础医学院生理学系，长沙 410013

摘要

肺纤维化是多种病因引起的累及肺间质、肺泡、细支气管的肺部慢性、弥漫性、间质性肺疾病，尚无有效的治疗药物。目前，外源性骨髓间充质干细胞(bone marrow-derived mesenchymal stem cells, BM-MSCs)移植作为一种新的干细胞疗法在治疗肺纤维化中的作用备受关注。目前对肺纤维化过程中内源性BM-MSCs功能状态的关注较少。本文在阐述BM-MSCs抗肺纤维化作用及其机制的基础上，进一步讨论了肺纤维化动物骨髓功能的异常变化，以及谷氨酸NMDA受体过度激活在肺纤维化所致内源性BM-MSCs功能抑制中的介导作用，为寻找肺纤维化的有效治疗方法提供潜在思路。 

关键词： 肺纤维化; 骨髓间充质干细胞; NMDA受体

分类号：R332

Research progress of endogenous bone marrow-derived mesenchymal stem cells in pulmonary fibrosis

LI Xiao-Hong¹, LUO Zi-Qiang^2,*

¹Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha 410011, China；²Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410013, China

Abstract

Pulmonary fibrosis is a chronic, diffuse, interstitial lung disease involving the pulmonary interstitium, alveoli, and bronchioles caused by various causes. There is no effective treatment. Currently, exogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation has attracted much attention as a new stem cell therapy in the treatment of pulmonary fibrosis. Less attention has been paid to the functional status of endogenous BM-MSCs during pulmonary fibrosis. Based on summary on the anti-pulmonary fibrosis effect of BM-MSCs and its mechanism, this review further discusses the abnormal changes of bone marrow function in animals with pulmonary fibrosis and the role of glutamate NMDA receptor overactivation in mediating the functional inhibition of endogenous BM-MSCs induced by pulmonary fibrosis. This will provide potential ideas for finding effective treatments for pulmonary fibrosis.

Key words: pulmonary fibrosis; bone marrow-derived mesenchymal stem cells; NMDA receptor

收稿日期：2019-12-11　　录用日期：2020-03-20

通讯作者：罗自强　　E-mail: E-mail: luoziqiang@csu.edu.cn

DOI: 10.13294/j.aps.2020.0055

引用本文：

李小红, 罗自强. 内源性骨髓间充质干细胞在肺纤维化中的研究进展[J]. 生理学报 2020; 72 (5): 597-604.

LI Xiao-Hong, LUO Zi-Qiang. Research progress of endogenous bone marrow-derived mesenchymal stem cells in pulmonary fibrosis. Acta Physiol Sin 2020; 72 (5): 597-604 (in Chinese with English abstract).